Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Neeraj K. Aryal"'
Autor:
Guillermina Lozano, Swathi Arur, Paul J. Goodfellow, David G. Mutch, Adel K. El-Naggar, Laura Baseler, Bobbie J. Rimel, Amanda R. Wasylishen, Vinod Pant, Neeraj K. Aryal
Tumors and Metastasis in KRas+/LA1;Dicer+/2SD mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cde849e5158b7c2ba3fc9ba794d8bc7
https://doi.org/10.1158/0008-5472.22418319.v1
https://doi.org/10.1158/0008-5472.22418319.v1
Autor:
Guillermina Lozano, Swathi Arur, Paul J. Goodfellow, David G. Mutch, Adel K. El-Naggar, Laura Baseler, Bobbie J. Rimel, Amanda R. Wasylishen, Vinod Pant, Neeraj K. Aryal
Dicer1 functions as a tumor suppressor in mouse models. In humans, somatic mutations are associated with many cancers in adults, and patients with DICER1 syndrome with DICER1 germline mutations are susceptible to childhood cancers. Dicer is phosphory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27a1f4ff00ef5131adf00d80e9f9005d
https://doi.org/10.1158/0008-5472.c.6510096.v1
https://doi.org/10.1158/0008-5472.c.6510096.v1
Autor:
Vinod Pant, Neeraj K. Aryal, Shunbin Xiong, Gilda P. Chau, Natalie W. Fowlkes, Guillermina Lozano
Publikováno v:
Cancer Res
Murine double minute 2 (Mdm2) is the principal E3-ubiquitin ligase for p53 and contains a C2H2C4 type RING domain wherein the last cysteine residue is followed by an evolutionarily conserved 13 amino acid C-terminal tail. Previous studies have indica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::893e4937b2738cd1acd576df7f70d71c
https://europepmc.org/articles/PMC8983537/
https://europepmc.org/articles/PMC8983537/
Autor:
Amanda R. Wasylishen, Gilda P. Chau, Guillermina Lozano, Ramesh C. Tailor, Neeraj K. Aryal, Vinod Pant, Shunbin Xiong, Connie A. Larsson
Publikováno v:
Proceedings of the National Academy of Sciences. 116:17429-17437
Gastrointestinal (GI) syndrome is a serious side effect and dose-limiting toxicity observed in patients undergoing lower-abdominal radiotherapy. Previous mouse studies show that p53 gene dosage determines susceptibility to GI syndrome development. Ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a41587e12757506bf59a533c63f4e525
https://doi.org/10.1073/pnas.1909550116
https://doi.org/10.1073/pnas.1909550116
Autor:
Guillermina Lozano, Xiaoping Su, Jeannelyn S. Estrella, Michael P. Kim, Sydney M. Moyer, Neeraj K. Aryal, Amanda R. Wasylishen, Michelle Craig Barton, Florencia McAllister, Yuan Qi, Chang Sun, Gilda P. Chau
Publikováno v:
Science Advances
Daxx loss causes coordinate dysregulation of ERVs and protein-coding genes after physiologic stress and impairs tissue recovery.
Tumor sequencing studies have emphasized the role of epigenetics and altered chromatin homeostasis in cancer. Mutati
Tumor sequencing studies have emphasized the role of epigenetics and altered chromatin homeostasis in cancer. Mutati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e902fc2a4ab9f249ace9c13b94fb513b
http://europepmc.org/articles/PMC7406367
http://europepmc.org/articles/PMC7406367
Autor:
Jan Parker-Thornburg, Elena McBeath, Yuka Fujii, Neeraj K. Aryal, Chad Smith, Keigi Fujiwara, Marie Claude Hofmann, Jun Ichi Abe
Publikováno v:
Genes
Volume 11
Issue 6
Genes, Vol 11, Iss 628, p 628 (2020)
Volume 11
Issue 6
Genes, Vol 11, Iss 628, p 628 (2020)
Although the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/ CRISPR associated protein 9 (Cas9) technique has dramatically lowered the cost and increased the speed of generating genetically engineered mice, success depends on usin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8016751032904365457899f721ceb217
Publikováno v:
Oncotarget
Increased levels of inhibitors of the p53 tumor suppressor such as Mdm2 and Mdm4 drive tumor development and thus serve as targets for therapeutic intervention. Recently, digestive organ expansion factor (Diexf) has been identified as a novel inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a08ca030862adf067b7b87d7ee9000f4
http://europepmc.org/articles/PMC5732782
http://europepmc.org/articles/PMC5732782
Autor:
Shunbin Xiong, Guillermina Lozano, Alfonso Quintás-Cardama, Vinod Pant, Neeraj K. Aryal, M. James You, Connie A. Larsson
Publikováno v:
Oncotarget
Disruption of the p53 tumor suppressor pathway is a primary cause of tumorigenesis. In addition to mutation of the p53 gene itself, overexpression of major negative regulators of p53, MDM2 and MDM4, also act as drivers for tumor development. Recent s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5240d016d6147bc60d870d48c720d5d
http://europepmc.org/articles/PMC5432220
http://europepmc.org/articles/PMC5432220
Autor:
Vinod Pant, M. James You, Neeraj K. Aryal, Yun Zhang, Donna F. Kusewitt, Guillermina Lozano, Shunbin Xiong
Publikováno v:
The Journal of Pathology. 241:501-510
The p53 inhibitor Mdm4 is present at high levels in multiple human cancers. Overexpression of Mdm4 in mice drives the spontaneous development of mostly lymphomas and sarcomas. In this study, we explored the ability of Mdm4 to cooperate with lesions i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b402cd66e59a6a284924d0b7fb137208
https://doi.org/10.1002/path.4854
https://doi.org/10.1002/path.4854
Autor:
Neeraj K, Aryal, Jan, Parker-Thornburg
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2066
Prior to generating a new mouse model, it is important to plan the method that will be used to detect which of the mice generated have the mutation(s) desired. Nearly, all types of mutations may be detected using PCR. However, the choice of primers w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d71c300698cb0224fa7575bd0e6bce4e
https://pubmed.ncbi.nlm.nih.gov/31512214
https://pubmed.ncbi.nlm.nih.gov/31512214