Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Neeraj, Lal"'
Autor:
Gary W. Middleton, Justin Guinney, Benjamin E. Willcox, Philippe Taniere, Andrew D. Beggs, Mike J. Mason, Oliver Pickles, Ghaleb Goussous, Brian S. White, Neeraj Lal
CIRC expression is downregulated in CMS2 CRC.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f5293de372c70bef15b7f2ea17b82f7
https://doi.org/10.1158/1078-0432.22462388
https://doi.org/10.1158/1078-0432.22462388
Autor:
Hisham Mehanna, Tanguy Y. Seiwert, Benjamin E. Willcox, Jean-Baptiste Cazier, Catharine M. L. West, Jonathan Deeks, Andrew D. Beggs, Daniel A. Tennant, Gary Middleton, Kalu U.E. Ogbureke, Steven P. Lee, Arun Khattri, Riyue Bao, Gordon B. Ryan, Baksho Kaul, Margaret Hartley, Jennifer L. Bryant, Nikolaos Batis, Rachel J. Spruce, Helen R. Valentine, Sandra V. von Zeidler, Christopher J. Bagnall, Neeraj Lal, Lucinda Archer, Maha Ibrahim, Albert N. Menezes, Jill M. Brooks
Purpose:Intratumoral hypoxia and immunity have been correlated with patient outcome in various tumor settings. However, these factors are not currently considered for treatment selection in head and neck cancer (HNC) due to lack of validated biomarke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb0f7d3ccb0356118104dd9a5b5c5f51
https://doi.org/10.1158/1078-0432.c.6527511.v1
https://doi.org/10.1158/1078-0432.c.6527511.v1
Autor:
Hisham Mehanna, Tanguy Y. Seiwert, Benjamin E. Willcox, Jean-Baptiste Cazier, Catharine M. L. West, Jonathan Deeks, Andrew D. Beggs, Daniel A. Tennant, Gary Middleton, Kalu U.E. Ogbureke, Steven P. Lee, Arun Khattri, Riyue Bao, Gordon B. Ryan, Baksho Kaul, Margaret Hartley, Jennifer L. Bryant, Nikolaos Batis, Rachel J. Spruce, Helen R. Valentine, Sandra V. von Zeidler, Christopher J. Bagnall, Neeraj Lal, Lucinda Archer, Maha Ibrahim, Albert N. Menezes, Jill M. Brooks
Figure S1. Gene order within the cluster defined groups. Figure S2. Analysis of individual hypoxia and immune gene signatures. Figure S3. Flow diagram showing progress of patient samples through study for Correlate cohort Figure S4. Relationship betw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cfab9a3f027758f48cf0cc051884977
https://doi.org/10.1158/1078-0432.22470306.v1
https://doi.org/10.1158/1078-0432.22470306.v1
Autor:
Gary W. Middleton, Justin Guinney, Benjamin E. Willcox, Philippe Taniere, Andrew D. Beggs, Mike J. Mason, Oliver Pickles, Ghaleb Goussous, Brian S. White, Neeraj Lal
Supplementary methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::009ef75671cdedc66da206b3dd102658
https://doi.org/10.1158/1078-0432.22462376.v1
https://doi.org/10.1158/1078-0432.22462376.v1
Autor:
Gary W. Middleton, Justin Guinney, Benjamin E. Willcox, Philippe Taniere, Andrew D. Beggs, Mike J. Mason, Oliver Pickles, Ghaleb Goussous, Brian S. White, Neeraj Lal
Purpose: KRAS mutation is a common canonical mutation in colorectal cancer, found at differing frequencies in all consensus molecular subtypes (CMS). The independent immunobiological impacts of RAS mutation and CMS are unknown. Thus, we explored the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a282e1cb502188917ef91fe9a53cb6e
https://doi.org/10.1158/1078-0432.c.6525092
https://doi.org/10.1158/1078-0432.c.6525092
Autor:
Oliver J. Pickles, Kasun Wanigasooriya, Anetta Ptasinska, Akshay J. Patel, Helen L. Robbins, Claire Bryer, Celina M. Whalley, Louise Tee, Neeraj Lal, Maria Pinna, Nahla Elzefzafy, Phillipe Taniere, Andrew D. Beggs, Gary W. Middleton
Publikováno v:
Cancer Research. 83:2989-2989
Introduction: Tumor specific MHC class II (tsMHC-II) expression impacts tumor microenvironmental immunity. tsMHC-II positive cancer cells act as surrogate antigen presenting cells and targets for CD4+ T cell-mediated lysis. In colorectal cancer (CRC)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3accfb5e078a2cd2bb682573f50c053
https://doi.org/10.1158/1538-7445.am2023-2989
https://doi.org/10.1158/1538-7445.am2023-2989
Autor:
Annette Pachnio, Miriam Ciaurriz, Jusnara Begum, Neeraj Lal, Jianmin Zuo, Andrew Beggs, Paul Moss
Publikováno v:
PLoS Pathogens, Vol 12, Iss 9, p e1005832 (2016)
Cytomegalovirus (CMV) infection elicits a very strong and sustained intravascular T cell immune response which may contribute towards development of accelerated immune senescence and vascular disease in older people. Virus-specific CD8+ T cell respon
Externí odkaz:
https://doaj.org/article/8a881bd64f2a40f38f9aae57fcdb8d35
Publikováno v:
Case Reports in Surgery, Vol 2016 (2016)
Colonic complications are rare after acute pancreatitis but are associated with a high mortality. Possible complications include mechanical obstruction, ischaemic necrosis, haemorrhage, and fistula. We report a case of large bowel obstruction in a 31
Externí odkaz:
https://doaj.org/article/7cecbca6b5b0467e8f287ce8ca4c8647
Autor:
Luis Tallon-Aguilar, Vincenzo Vigorita, Alethea Tang, Simone Conci, VALERIA TONINI, Maria Carmela Giuffrida, JUAN-CARLOS GOMEZ-ROSADO, Mudassar Ali Ghazanfar, Francesco Fleres, Zahir Mughal, David Ambrona Zafra, Muhamed Farhan-Alanie, Gianluca Garulli, Rhiannon Harries, Michael Wilson, Chiara Listorti, Hugo Santos-Sousa, Mario Rodriguez-Lopez, Tommaso Stecca, Marco Calussi, Antonio Martino, Gianluca Pellino, Emad Aly, Giuseppe Sena, Salomone Di Saverio, Giulia Montori, Leonardo Solaini, Fabio Staderini, Juan Carlos Sebastián-Tomás, Eugenio Cucinotta, Paolo Checcacci, Richard Egan, Ana Alagoa Joao, Diego Sasia, Fady Yanni, Jorge Arredondo, Walid Mohamed, Helena Salvador Roses, Daniel Ashmore, Rachel Mahoney, Sathyan Nagendram, Daniel Ahern, Alex Boddy, FABIO CIANCHI, Pedro Villarejo campos, Victoriano Soria Aledo, Alexandros Charalabopoulos, Vania Silvestri, Kathryn Lee, Allan Golder, Margarida Ferreira, Nicholas Mowbray, Marianne Hollyman, Dennis Ho-Yin Lui, Uday Prasad, Elisa Francone, Arina Anna Tamborska, Marco Inama, Michele Ballabio, João Martins Guimarães, Marco Scatizzi, Martin Connor, Jose Luis Rodicio Miravalles, Carmen Payá-Llorente, Jonathan Shurlock, Francesco Colombo, Thomas Pinkney, Chloe Swords, Patricio Fernando Gálvez Salazar, Luigi Marano, Daniel Fernández Martínez, Andrea Pietrabissa, M. ANGELES CALVO TORRAS, Martín Bailón, Angela Belvedere, Isabel Pascual Miguelañez, Hiten Patel, Edward Balai, Leo Licari, Luca Ansaloni, Ian Daniels, Segundo Gomez-Abril, Vincenzo Lizzi, Jonathan Lund, Carmelo Mazzeo, Peter Coe, FRANCESCO ENRICO D'AMICO, Mauro Podda, Pere Planellas Giné, Peter Cay, David Merlini, Natalie Blencowe, Paola De Nardi, Giuseppe SALAMONE, Emilio Padilla, James Glasbey, Andrea Giorga, Carlos Cerdán Santacruz, Francesca Viscosi, Stefano Scabini, Maria Moreno Gijon, Nicola Cillara, Paul Glen, Sushil Maslekar, Francesco Maria Carrano, Mary Venn, Franco Marinello, Francisco Javier Redondo Calvo, James Haddow, Unai De Andres Olabarria, Frances Wensley, Munir Tarazi, Emily Farrow, Sirio Melone, Chia Yew Kong, Andrea-Pierre Luzzi, Dr Rochelle Velho MBChB MPH (Merit) BSc (Hons), Jeancarlos Trujillo Díaz, Richard Wilkin, Enrique Toledo Martínez, Noel Aruparayil, Mohamed Rabie, SAMUELE VACCARI, José Azevedo, Andrea Bondurri, Philip Herrod, Georgia Layton, Luca Ponchietti, Núria Lluís, James Olivier, Piers Boshier, Spyridon Panagiotopoulos, David Naumann, Adam Misky, Anna Maffioli, Nuno Carvalho, Daniele Delogu, Diego Coletta, Panagiotis Sgardelis, FELIPE PAREJA CIURO, Oliver Warren, Luis Eduardo Pérez-Sánchez, Neeraj Lal, Ruth Blanco-Colino, Sarah Whitehorn, Shahab Hajibandeh, Alexander Christides, Andrea Simioni, Nigel Jamieson, Navamayooran Thavanesan, Monika Rezacova, Gaetano Poillucci, Rucira Ooi, Michele Rubbini, Alessandra Marano, Eloy Espin-Basany, Emanuele Gammeri, Michele Altomare, Laura Pérez-Sánchez, James Archer, Gaetano Gallo, Chung Shen Chean, Ferdinando Agresta, Aneel Bhangu, James Kinross, Gianfranco Cocorullo, Francisco J Tejero-Pintor, Siobhan McKay, Marc Vallve-Bernal, Juan José Segura-Sampedro, Fahad Mahmood
Publikováno v:
British Journal of Surgery. 107:73-86
Funding Information: The authors are grateful to the Birmingham Surgical Trials Consortium at the University of Birmingham for the use of their servers for secure online data collection. Disclosure: The authors declare no conflict of interest.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6159209de717f0649735169c0fe27a1b
https://doi.org/10.1002/bjs.11440
https://doi.org/10.1002/bjs.11440
Autor:
Neeraj Lal, Riyue Bao, Sandra Ventorin Von Zeidler, Arun Khattri, Helen R Valentine, Albert N. Menezes, Jean-Baptiste Cazier, Hisham Mehanna, Tanguy Y. Seiwert, Maha Ibrahim, Steven P. Lee, Jonathan J Deeks, Lucinda Archer, Daniel A. Tennant, Andrew D Beggs, Christopher Bagnall, Margaret Hartley, Nikolaos Batis, Kalu U.E. Ogbureke, Baksho Kaul, Jill Brooks, Gary Middleton, Jennifer L. Bryant, Catharine M L West, Gordon B. Ryan, Rachel Spruce, Benjamin E. Willcox
Publikováno v:
Clinical Cancer Research. 25:5315-5328
Purpose: Intratumoral hypoxia and immunity have been correlated with patient outcome in various tumor settings. However, these factors are not currently considered for treatment selection in head and neck cancer (HNC) due to lack of validated biomark
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d61c3804c04d4d409c1b16a6bd663753
https://doi.org/10.1158/1078-0432.ccr-18-3314
https://doi.org/10.1158/1078-0432.ccr-18-3314