Zobrazeno 1 - 10
of 155
pro vyhledávání: '"Neeraj, Kohli"'
Autor:
Melissa L. Geddie, Dmitri B. Kirpotin, Neeraj Kohli, Tad Kornaga, Bjoern Boll, Maja Razlog, Daryl C. Drummond, Alexey A. Lugovskoy
Publikováno v:
mAbs, Vol 14, Iss 1 (2022)
Antibody-directed nanotherapeutics (ADNs) represent a promising delivery platform for selective delivery of an encapsulated drug payload to the site of disease that improves the therapeutic index. Although both single-chain Fv (scFv) and Fab antibody
Externí odkaz:
https://doaj.org/article/9d2891dc79f643129c3b3b205c1860ca
Autor:
Beni B. Wolf, Ulrik B. Nielsen, Jonathan B. Fitzgerald, Anne M. King, Callum M. Sloss, Olga Burenkova, Neeraj Kohli, Shannon L. Werner, Nastaran Gerami-Moayed, Gege Tan, Mark Sevecka, Raghida Bukhalid, Jeffrey D. Kearns
Supplementary Methods, Figures S1-S11, and Table Legends. Supplementary Methods: description of methods used in the Supplementary figures, expanded description of ELISA assays, and description of the computational model of multiple EGFR ligand antago
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d0589dd9379473a98d20e9845ac6751
https://doi.org/10.1158/1535-7163.22501833.v1
https://doi.org/10.1158/1535-7163.22501833.v1
Autor:
Beni B. Wolf, Ulrik B. Nielsen, Jonathan B. Fitzgerald, Anne M. King, Callum M. Sloss, Olga Burenkova, Neeraj Kohli, Shannon L. Werner, Nastaran Gerami-Moayed, Gege Tan, Mark Sevecka, Raghida Bukhalid, Jeffrey D. Kearns
Supplementary Tables S2, S3, S4. Structure of the computational model of multiple ligand antagonists: species (Table S2), parameters (Table S3), and Reactions (Table S4).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c534d560032452e0b5101eea8d16d10b
https://doi.org/10.1158/1535-7163.22501827
https://doi.org/10.1158/1535-7163.22501827
Autor:
Ulrik B. Nielsen, Birgit Schoeberl, Arthur J. Kudla, Michael J. Feldhaus, Matt Wallace, Neeraj Kohli, Jinming Gu, Stephanie Nguyen, Ryan Overland, Lia Luus, Bo Zhang, Shinji Oyama, Violette Paragas, Sharlene Adams, Brian D. Harms, Alexandra Huhalov, Charlotte F. McDonagh
PDF file - 189K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::740c3b57b3148fec19b2a1932a1c942b
https://doi.org/10.1158/1535-7163.22498605
https://doi.org/10.1158/1535-7163.22498605
Autor:
Alexey A. Lugovskoy, Ulrik B. Nielsen, Birgit Schoeberl, Kenneth J. Olivier, Brian D. Harms, Yang Jiao, Maja Razlog, Rachel Rennard, Neeraj Kohli, Lihui Xu, Victoria Rimkunas, Jian Tang, Sergio Iadevaia, Sharlene Adams, Jason Baum, Bryan W. Johnson, Jonathan B. Fitzgerald
PDF - 111K, Additional details on the implementation and training of the mechanistic model.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63a54401ccec2fdca3751258fe817721
https://doi.org/10.1158/1535-7163.22500898.v1
https://doi.org/10.1158/1535-7163.22500898.v1
Autor:
Greg M. Thurber, Richard Gregory, Jan Pinkas, Ravi Chari, Thomas A. Keating, Michael L. Miller, Yulius Setiady, Bahar Matin, Neeraj Kohli, Christopher Espelin, Olga Ab, Rassol Laleau, Eshita Khera, Leanne Lanieri, Jose F. Ponte
Supplementary figures and data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::633ee436ae1eb2f1537f2ada328961b9
https://doi.org/10.1158/1535-7163.22521463
https://doi.org/10.1158/1535-7163.22521463
Autor:
Beni B. Wolf, Ulrik B. Nielsen, Jonathan B. Fitzgerald, Anne M. King, Callum M. Sloss, Olga Burenkova, Neeraj Kohli, Shannon L. Werner, Nastaran Gerami-Moayed, Gege Tan, Mark Sevecka, Raghida Bukhalid, Jeffrey D. Kearns
Supplementary Table S1. Cell lines and cell culture conditions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0501a563d004db70756494b7092751e4
https://doi.org/10.1158/1535-7163.22501830
https://doi.org/10.1158/1535-7163.22501830
Autor:
Alexey A. Lugovskoy, Ulrik B. Nielsen, Birgit Schoeberl, Kenneth J. Olivier, Brian D. Harms, Yang Jiao, Maja Razlog, Rachel Rennard, Neeraj Kohli, Lihui Xu, Victoria Rimkunas, Jian Tang, Sergio Iadevaia, Sharlene Adams, Jason Baum, Bryan W. Johnson, Jonathan B. Fitzgerald
Although inhibition of the insulin-like growth factor (IGF) signaling pathway was expected to eliminate a key resistance mechanism for EGF receptor (EGFR)-driven cancers, the effectiveness of IGF-I receptor (IGF-IR) inhibitors in clinical trials has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63aadf5ac0a5228ff209cf3c30de8a8a
https://doi.org/10.1158/1535-7163.c.6536614.v1
https://doi.org/10.1158/1535-7163.c.6536614.v1
Autor:
Beni B. Wolf, Ulrik B. Nielsen, Jonathan B. Fitzgerald, Anne M. King, Callum M. Sloss, Olga Burenkova, Neeraj Kohli, Shannon L. Werner, Nastaran Gerami-Moayed, Gege Tan, Mark Sevecka, Raghida Bukhalid, Jeffrey D. Kearns
Supplementary Tables S5, S6, S7, S8. mRNA expression data for EGFR ligands as measured by RNAseq from The Cancer Genome Atlas (TCGA) across 14 cancer indications or by RT-qPCR of colorectal cancer FFPE samples. Table S5: Summary of TCGA datasets incl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5782fe1fa8c256671852ceadb513a3f4
https://doi.org/10.1158/1535-7163.22501824
https://doi.org/10.1158/1535-7163.22501824
Autor:
Alexey A. Lugovskoy, Ulrik B. Nielsen, Birgit Schoeberl, Kenneth J. Olivier, Brian D. Harms, Yang Jiao, Maja Razlog, Rachel Rennard, Neeraj Kohli, Lihui Xu, Victoria Rimkunas, Jian Tang, Sergio Iadevaia, Sharlene Adams, Jason Baum, Bryan W. Johnson, Jonathan B. Fitzgerald
PDF - 711K, Supplemental Figure S1. Schematic representation of components of IGF-1R/ErbB3 merged mechanistic signaling model. Supplemental Table S1. Mean ligand-stimulated pAKT (S473) levels (A) or simulated levels (B) in BxPC-3, AdRr and MCF7 cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9badea55c07244efa7d070174e73781
https://doi.org/10.1158/1535-7163.22500901
https://doi.org/10.1158/1535-7163.22500901