Zobrazeno 1 - 10 of 59 pro vyhledávání: '"Neera, Raghav"'
1
Akademický článek
Novel 1,2,3-triazole-aurone hybrids as cathepsin B inhibitors: One-pot synthesis, anti-proliferative, and drug modeling studies
Autor: Bhavna Saroha, Gourav Kumar, Suresh Kumar, Meena Kumari, Manishita Rani, Neera Raghav, Pranab Kumar Sahoo, Sushmita Ghosh, Sutapa Mahata, Vilas D. Nasare
Publikováno v: European Journal of Medicinal Chemistry Reports, Vol 5, Iss , Pp 100056- (2022)
In the present study, we have designed a series of novel 1,2,3-triazole-aurone hybrids, which were synthesized by a one-pot click reaction between a terminal alkyne and an in-situ generated azide, and evaluated as potential cathepsin B inhibitors. Th
Externí odkaz: https://doaj.org/article/57e7e7f4dc694399828bc1e66d6b20cd
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2
Akademický článek
Ultrasound assisted a one pot multicomponent and greener synthesis of 1,2,3-triazole incorporated aurone hybrids: Cathepsin B inhibition, anti-cancer activity against AGS cell line, and in-silico docking evaluation
Autor: Bhavna Saroha, Gourav Kumar, Suresh Kumar, Meena Kumari, Manishita Rani, Neera Raghav, Pranab Kumar Sahoo, Sushmita Ghosh, Sutapa Mahata, Vilas D. Nasare
Publikováno v: Current Research in Green and Sustainable Chemistry, Vol 5, Iss , Pp 100295- (2022)
Cathepsin B represents a group of lysosomal-encapsulated cellular cysteine proteases, whose upregulation is the critical risk factor for cancer progression and in the regulation of degenerative processes like apoptosis. Therefore, cysteine cathepsins
Externí odkaz: https://doaj.org/article/3023cb4c38b645eeb629842a4e3bb768
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3
An ultrasound-assisted three component protocol for the regio and stereo-selective synthesis of some novel dispiroheterocycles and their biological evaluation as anti-inflammatory, anti-obesity agents
Autor: Suresh Kumar, Sanjeev Kumar, Bhavna Saroha, Ekta Lathwal, Gourav Kumar, Ramesh Kumar, Priyanka Arya, Neera Raghav
Publikováno v: Letters in Drug Design & Discovery. 20
aims: Greener Synthesis and biological evaluation of some novel dispiroheterocycles background: The increasing utilization of spiro compounds in drug discovery, led us to design and synthesize regioselectively some novel dispiroheterocycles, by a sta
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::afd32b8fe56ca03b11fc524b7a977f4f
https://doi.org/10.2174/1570180820666230306115855
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6
A decennary update on diverse heterocycles and their intermediates as privileged scaffolds for cathepsin B inhibition
Autor: Bhavna Saroha, Gourav Kumar, Meena Kumari, Ravinder Kaur, Neera Raghav, Pawan K. Sharma, Naveen Kumar, Suresh Kumar
Publikováno v: International journal of biological macromolecules. 222
The identification of x-ray crystal structure of cathepsin B (CTSB) in the early 90's enabled researchers to embark on a journey to understand and demystify its multiple catalytic mechanisms (endopeptidase/carboxypeptidase/peptidyl-dipeptidase) in di
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5374fa085685fb2d2d7e762b71b66804
https://pubmed.ncbi.nlm.nih.gov/36216101
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10
Comparative study of covalent and hydrophobic interactions for α-amylase immobilization on cellulose derivatives
Autor: Neera Raghav, Nitin Kumar Verma
Publikováno v: International Journal of Biological Macromolecules. 174:134-143
Indispensability of enzymes in living systems, their unique characteristics and simultaneous focus on development of greener methods have led to substitution of various chemical reactions by enzyme catalyzed reactions. One of the aspects in enzyme re
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1264fbc296a5cd266912d921d5c3883b
https://doi.org/10.1016/j.ijbiomac.2021.01.033
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