Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Neelu Kaila"'
Autor:
Scott Daigle, David Ciccone, Samantha Carreiro, Christine Loh, Neelu Kaila, Fu-Shan Kuo, Scott Boiko, Gene Yau, Esha A Gangolli, Denise Levasseur, Bhaskar Srivastava, Frank G Basile
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/d7116d7f7b804a0885f65ce7d1bf0e25
Autor:
Diane L. Rosin, J. Perry Hall, Shuqiu Zheng, Liping Huang, Silvia Campos-Bilderback, Ruben Sandoval, Andrea Bree, Kevin Beaumont, Emily Miller, Jennifer Larsen, Ghazal Hariri, Neelu Kaila, Iain M. Encarnacion, Jeremy D. Gale, Andrea van Elsas, Bruce A. Molitoris, Mark D. Okusa
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
Adenosine triphosphate (ATP) released from injured or dying cells is a potent pro-inflammatory “danger” signal. Alkaline phosphatase (AP), an endogenous enzyme that de-phosphorylates extracellular ATP, likely plays an anti-inflammatory role in im
Externí odkaz:
https://doaj.org/article/8a48422a8c3f4fea9d0b25430207d3fe
Autor:
David Ciccone, Vad Lazari, Ian Linney, Michael Briggs, Samantha Carreiro, Joshua McElwee, Ian Waddell, Chris Hill, Christine Loh, Peter Tummino, Alan Collis, Neelu Kaila
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Externí odkaz:
https://doaj.org/article/11f4cb29b7ee40dfb6994ec7c3098018
Autor:
Neelu Kaila, Ian Linney
Publikováno v:
Expert Opinion on Therapeutic Patents. 31:893-910
Introduction: Hematopoietic progenitor kinase (HPK1), a serine/threonine kinase, which is primarily expressed in hematopoietic cells is a negative regulator of T-cell receptor and B cell signaling. Studies using genetic disruption of HPK1 function sh
Autor:
Jesse M Hansen, Joshua J McElwee, Eric M. Lynch, Kevin D Kreutter, Gydo C. P. van Zundert, Michael A. DiMattia, Joel Quispe, Andreas Verras, Steven K. Albanese, Neelu Kaila, Justin M. Kollman, Angela V. Toms, Madison Arza Kennedy, Kenneth W. Borrelli
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance An effective immune response depends on the proliferation of T cells, a process that requires the enzyme CTP synthase 1 (CTPS1). Individuals lacking CTPS1 due to a rare genetic disorder exhibit severe immunodeficiencies but lack other ma
Autor:
Joshua McElwee, Vad Lazari, Peter Tummino, Chris Hill, Ian D. Waddell, Ian Linney, Neelu Kaila, Christine Loh, Alan Collis, David Ciccone, Samantha Carreiro, Michael Briggs
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background HPK1, a member of the MAP4K family of protein serine/threonine kinases, is involved in regulating signal transduction cascades in cells of hematopoietic origin. Recent data from HPK1 knockout animals and kinase-inactive knock-in animals un
Autor:
Seungil Han, Martin E. Dowty, Ralph P. Robinson, Steven E. Heasley, Peter T. Symanowicz, Jason Jussif, Thomas M. Harris, Neelu Kaila, Lu Wang, Matthew Frank Brown, Jeffrey M. Casavant, Nicole Caspers, Sarah H. Griffin, Mark J. Mitton-Fry, Martin Hegen, Johnson Timothy Allan, Tenbrink Ruth E, Mary Ellen Banker, Jonathan Langille, Mihir D. Parikh, Tsung H. Lin, Arindrajit Basak, Jean-Baptiste Telliez, James D. Clark, Strohbach Joseph Walter, Eric P. Arnold, Ray Unwalla, Li Li, Brian A. Duclos, Xin Yang, Mark Edward Flanagan, John David Trzupek, Michael L. Vazquez, Soojin Kwon, Ashley Edward Fenwick
Publikováno v:
Journal of Medicinal Chemistry. 61:1130-1152
Janus kinases (JAKs) are intracellular tyrosine kinases that mediate the signaling of numerous cytokines and growth factors involved in the regulation of immunity, inflammation, and hematopoiesis. As JAK1 pairs with JAK2, JAK3, and TYK2, a JAK1-selec
Autor:
Neelu Kaila, Vad Lazari, Michael Briggs, Alan Collis, Ian Linney, Samantha Carreiro, Peter Tummino, Christine Loh, David Ciccone, Joshua J McElwee
Publikováno v:
Cancer Research. 81:1649-1649
Background: HPK1, a member of the MAP4K family of protein serine/threonine kinases, is involved in negatively regulating signal transduction cascades in cells of hematopoietic origin. Recent data generated using potent and highly selective HPK1 inhib
Autor:
Ravi G. Kurumbail, Eric Johnson, Nicole Caspers, Timothy A. Subashi, Michael L. Vazquez, Francis Rajamohan, Lise R. Hoth, Neelu Kaila, Kieran F. Geoghegan, Ciarán N. Cronin, Seungil Han
Publikováno v:
Acta Crystallographica Section F Structural Biology Communications. 72:840-845
Crystals of phosphorylated JAK1 kinase domain were initially generated in complex with nucleotide (ADP) and magnesium. The tightly bound Mg2+-ADP at the ATP-binding site proved recalcitrant to ligand displacement. Addition of a molar excess of EDTA h
Autor:
David Ciccone, C. Loh, Samantha Carreiro, Alan Collis, Vad Lazari, Ian Linney, Peter Tummino, Neelu Kaila, Ian D. Waddell, Chris Hill, Michael Briggs
Publikováno v:
European Journal of Cancer. 138:S20