Supplementary Fig. 5 from Hypoxia Attenuates Trastuzumab Uptake and Trastuzumab-Emtansine (T-DM1) Cytotoxicity through Redistribution of Phosphorylated Caveolin-1

Autor: Mattias Belting, Helena Jernström, Ivan Robert Nabi, Karin Jirström, Signe Borgquist, Karolin Isaksson, Oleg Gluz, Ola M. Saad, Neelima Koppada, Bharat Joshi, Björn Nodin, Myriam Cerezo-Magaña, Magdalena Barbachowska, Ann-Sofie Månsson, Vineesh Indira Chandran

Figure S5. Flow chart of the selection process of patients.

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https://doi.org/10.1158/1541-7786.22517380.v1

Supplementary Table 1 from Hypoxia Attenuates Trastuzumab Uptake and Trastuzumab-Emtansine (T-DM1) Cytotoxicity through Redistribution of Phosphorylated Caveolin-1

Autor: Mattias Belting, Helena Jernström, Ivan Robert Nabi, Karin Jirström, Signe Borgquist, Karolin Isaksson, Oleg Gluz, Ola M. Saad, Neelima Koppada, Bharat Joshi, Björn Nodin, Myriam Cerezo-Magaña, Magdalena Barbachowska, Ann-Sofie Månsson, Vineesh Indira Chandran

Supplementary Table 1. Patient and tumor characteristics in relation to tumor-specific cytoplasmic intensity of CAV1

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https://doi.org/10.1158/1541-7786.22517371

Supplementary Fig. 2 from Hypoxia Attenuates Trastuzumab Uptake and Trastuzumab-Emtansine (T-DM1) Cytotoxicity through Redistribution of Phosphorylated Caveolin-1

Autor: Mattias Belting, Helena Jernström, Ivan Robert Nabi, Karin Jirström, Signe Borgquist, Karolin Isaksson, Oleg Gluz, Ola M. Saad, Neelima Koppada, Bharat Joshi, Björn Nodin, Myriam Cerezo-Magaña, Magdalena Barbachowska, Ann-Sofie Månsson, Vineesh Indira Chandran

S2. Phospho-kinase antibody array analyses of normoxia (a) or hypoxia (b) level expressed as normalized to reference standard.

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https://doi.org/10.1158/1541-7786.22517389

Supplementary Fig. 7 from Hypoxia Attenuates Trastuzumab Uptake and Trastuzumab-Emtansine (T-DM1) Cytotoxicity through Redistribution of Phosphorylated Caveolin-1

Autor: Mattias Belting, Helena Jernström, Ivan Robert Nabi, Karin Jirström, Signe Borgquist, Karolin Isaksson, Oleg Gluz, Ola M. Saad, Neelima Koppada, Bharat Joshi, Björn Nodin, Myriam Cerezo-Magaña, Magdalena Barbachowska, Ann-Sofie Månsson, Vineesh Indira Chandran

Figure S7. Histology of primary breast cancer tissue.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ea3ddb1374093736cdbbe985da60c4c
https://doi.org/10.1158/1541-7786.22517374.v1

Hypoxia attenuates trastuzumab uptake and trastuzumab-emtansine (T-DM1) cytotoxicity through redistribution of phosphorylated caveolin-1

Autor: Oleg Gluz, Vineesh Indira Chandran, Helena Jernström, Karin Jirström, Mattias Belting, Neelima Koppada, Signe Borgquist, Bharat H. Joshi, Karolin Isaksson, Ola Saad, Ivan R. Nabi, Myriam Cerezo-Magaña, Ann-Sofie Månsson, Magdalena Barbachowska, Björn Nodin

Publikováno v: Chandran, V I, Mansson, A S, Barbachowska, M, Cerezo-Magana, M, Nodin, B, Joshi, B, KoppaD.A., N, Saad, O M, Gluz, O, Isaksson, K, Borgquist, S, Jirstrom, K, Nabi, I R, Jernstrom, H & Belting, M 2020, ' Hypoxia attenuates trastuzumab uptake and trastuzumab-emtansine (T-DM1) cytotoxicity through redistribution of phosphorylated caveolin-1 ', Molecular Cancer Research, vol. 18, no. 4, pp. 644-656 . https://doi.org/10.1158/1541-7786.MCR-19-0856

The antibody–drug conjugate trastuzumab-emtansine (T-DM1) offers an additional treatment option for patients with HER2-amplified tumors. However, primary and acquired resistance is a limiting factor in a significant subset of patients. Hypoxia, a h

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https://pure.au.dk/portal/da/publications/hypoxia-attenuates-trastuzumab-uptake-and-trastuzumabemtansine-tdm1-cytotoxicity-through-redistribution-of-phosphorylated-caveolin1(cf561575-5081-4e82-b415-86ad772ec081).html