Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Neelie Zacharias"'
Autor:
Akshay T. Krishnamurty, Justin A. Shyer, Minh Thai, Vineela Gandham, Matthew B. Buechler, Yeqing Angela Yang, Rachana N. Pradhan, Amber W. Wang, Patricia L. Sanchez, Yan Qu, Beatrice Breart, Cécile Chalouni, Debra Dunlap, James Ziai, Justin Elstrott, Neelie Zacharias, Weiguang Mao, Rebecca K. Rowntree, Jack Sadowsky, Gail D. Lewis, Thomas H. Pillow, Barzin Y. Nabet, Romain Banchereau, Lucinda Tam, Roger Caothien, Natasha Bacarro, Merone Roose-Girma, Zora Modrusan, Sanjeev Mariathasan, Sören Müller, Shannon J. Turley
Publikováno v:
Nature. 611:148-154
Recent single-cell studies of cancer in both mice and humans have identified the emergence of a myofibroblast population specifically marked by the highly restricted leucine-rich-repeat-containing protein 15 (LRRC15)1–3. However, the molecular sign
Autor:
Neelie Zacharias, Vladimir N. Podust, Kimberly K. Kajihara, Douglas Leipold, Geoffrey Del Rosario, Desiree Thayer, Emily Dong, Maciej Paluch, David Fischer, Kai Zheng, Corinna Lei, Jintang He, Carl Ng, Dian Su, Luna Liu, Shabkhaiz Masih, William Sawyer, Jeff Tinianow, Jan Marik, Victor Yip, Guangmin Li, Josefa Chuh, J. Hiroshi Morisaki, Summer Park, Bing Zheng, Hilda Hernandez-Barry, Kelly M. Loyet, Min Xu, Katherine R. Kozak, Gail Lewis Phillips, Ben-Quan Shen, Cong Wu, Keyang Xu, Shang-Fan Yu, Amrita Kamath, Rebecca K. Rowntree, Dorothea Reilly, Thomas Pillow, Andrew Polson, Volker Schellenberger, Wouter L. W. Hazenbos, Jack Sadowsky
Publikováno v:
Chemical Science. 13:3147-3160
The antibody-drug conjugate (ADC) is a well-validated modality for the cell-specific delivery of small molecules with impact expanding rapidly beyond their originally-intended purpose of treating cancer. However, antibody-mediated delivery (AMD) rema
Autor:
Akshay T, Krishnamurty, Justin A, Shyer, Minh, Thai, Vineela, Gandham, Matthew B, Buechler, Yeqing Angela, Yang, Rachana N, Pradhan, Amber W, Wang, Patricia L, Sanchez, Yan, Qu, Beatrice, Breart, Cécile, Chalouni, Debra, Dunlap, James, Ziai, Justin, Elstrott, Neelie, Zacharias, Weiguang, Mao, Rebecca K, Rowntree, Jack, Sadowsky, Gail D, Lewis, Thomas H, Pillow, Barzin Y, Nabet, Romain, Banchereau, Lucinda, Tam, Roger, Caothien, Natasha, Bacarro, Merone, Roose-Girma, Zora, Modrusan, Sanjeev, Mariathasan, Sören, Müller, Shannon J, Turley
Publikováno v:
Nature. 611(7934)
Recent single-cell studies of cancer in both mice and humans have identified the emergence of a myofibroblast population specifically marked by the highly restricted leucine-rich-repeat-containing protein 15 (LRRC15)
Autor:
Volker Schellenberger, David Fischer, Bing Zheng, Thomas H. Pillow, Amrita V. Kamath, Carl Ng, Jan Marik, Corinna Lei, Dorothea Reilly, Shabkhaiz Masih, Kelly M. Loyet, Vladimir N. Podust, Kimberly Kajihara, Maciej Paluch, Andrew Polson, Gail Dianne Phillips, Summer Park, Luna Liu, Morisaki John Hiroshi, Kai Zheng, Guangmin Li, Dian Su, Douglas D. Leipold, Josefa Chuh, Victor Yip, Emily Dong, Shang-Fan Yu, Wouter L. W. Hazenbos, Jack Sadowsky, Geoffrey Del Rosario, Rebecca K. Rowntree, Jeff N. Tinianow, Neelie Zacharias, Min Xu, William S. Sawyer, Katherine R. Kozak, Hilda Hernandez-Barry, Jintang He, Cong Wu, Keyang Xu, Ben-Quan Shen
Antibody-drug conjugates (ADCs) enable cell-specific delivery of small molecules and are validated anti-cancer therapeutics. One factor limiting ADC advancement and broader application is the drug-to-antibody ratio (DAR), which dictates the number of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7d05e7d54cc2ba403b546592bdee064
https://doi.org/10.21203/rs.3.rs-356231/v1
https://doi.org/10.21203/rs.3.rs-356231/v1
Autor:
Gordy Bullen, Siao Ping Tsai, Josefa dela Cruz-Chuh, Neelie Zacharias, Erick Velasquez, Suzie J. Scales, Jack Sadowsky, Elise Bruguera, Julie Chang, Katherine R. Kozak
Publikováno v:
Bioconjugate chemistry. 30(12)
Disulfide-linked bioconjugates allow the delivery of pharmacologically active or other cargo to specific tissues in a redox-sensitive fashion. However, an understanding of the kinetics, subcellular distribution, and mechanism of disulfide cleavage in
Autor:
Kalli C. Catcott, Susan Clardy, Jack Sadowsky, Rebecca K. Rowntree, Naniye Malli Centibas, Ling Xu, Andy Polson, Kenneth Avocetien, Tyler Carter, Mark Nazzaro, Dokyong \\'DK\\' Kim, Thomas H. Pillow, Neelie Zacharias, Cong Wu, Jeffrey Zurita, Elizabeth Ditty, Stephen Bradley, Alex Uttard, Bingfan Du, William S. Sawyer, Doug Leipold, Gail Lewis Phillips, LiuLiang Qin, Kelly Slocum, Geoffrey Del Rosario, Ginny Li, Shang-Fan Yu, David Lee, Radha Iyengar, Marc Damelin, Dorin Toader, Timothy B. Lowinger
Publikováno v:
Molecular Cancer Therapeutics. 20:P167-P167
Key defining attributes of an antibody-drug conjugate (ADC) include the choice of targeting antibody, linker, and the drug-to-antibody ratio (DAR). The choice of DAR, within the constraints of acceptable physicochemical properties for the given platf
Publikováno v:
Methods in Molecular Biology ISBN: 9781493999286
Antibodies bearing engineered cysteine residues (termed THIOMAB™ antibodies) enable the site-selective attachment of a drug, label or other payload for specific delivery to certain tissues (e.g., tumors). This Chapter describes detailed methods we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c33d1c29525e773c56a9bff0a9528c16
https://doi.org/10.1007/978-1-4939-9929-3_4
https://doi.org/10.1007/978-1-4939-9929-3_4
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2078
Antibodies bearing engineered cysteine residues (termed THIOMAB™ antibodies) enable the site-selective attachment of a drug, label or other payload for specific delivery to certain tissues (e.g., tumors). This Chapter describes detailed methods we
Autor:
Nicholas Vance, Neelie Zacharias, Mark Ultsch, Guangmin Li, Aimee Fourie, Peter Liu, Julien LaFrance-Vanasse, James A. Ernst, Wendy Sandoval, Katherine R. Kozak, Gail Phillips, Weiru Wang, Jack Sadowsky
Publikováno v:
Bioconjugate chemistry. 30(1)
Site-specific conjugation of small molecules to antibodies represents an attractive goal for the development of more homogeneous targeted therapies and diagnostics. Most site-specific conjugation strategies require modification or removal of antibody