Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Neele Drobnitzky"'
Autor:
Nuramalina H. Mumin, Neele Drobnitzky, Agata Patel, Luiza Madia Lourenco, Fiona F. Cahill, Yanyan Jiang, Anthony Kong, Anderson J. Ryan
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-14 (2019)
Abstract Background Due to the lack of effective therapies and poor prognosis in TNBC (triple-negative breast cancer) patients, there is a strong need to develop effective novel targeted therapies for this subtype of breast cancer. Inhibition of heat
Externí odkaz:
https://doaj.org/article/69534f213e83452c8a4a36b41f55fde1
Autor:
Aung Naing, Daniel D. Karp, Filip Janku, Anderson J. Ryan, Funda Meric-Bernstam, Sarina Anne Piha-Paul, Gerald Steven Falchook, Siquing Fu, Steven I. Sherman, Tina Cascone, John V. Heymach, R.L. Sacks, Neele Drobnitzky, Anthony P. Conley, Vivek Subbiah, Ishwaria Mohan Subbiah, Behrang Amini, David S. Hong, KR Hess, Tarak Bhatt
Publikováno v:
ESMO Open
Background Preclinical studies suggest that combining vandetanib (VAN), a multi-tyrosine kinase inhibitor of rearranged during transfection (RET) proto-oncogene, vascular endothelial growth factor receptor (VEGFR), and epidermal growth factor recepto
Autor:
Nuramalina H. Mumin, Neele Drobnitzky, Agata Patel, Luiza Madia Lourenco, Fiona F. Cahill, Yanyan Jiang, Anthony Kong, Anderson J. Ryan
Publikováno v:
BMC Cancer
Mumin, N H, Drobnitzky, N, Patel, A, Lourenco, L M, Cahill, F F, Jiang, Y, Kong, A & Ryan, A J 2019, ' Overcoming acquired resistance to HSP90 inhibition by targeting JAK-STAT signalling in triple-negative breast cancer ', BMC Cancer, vol. 19, no. 1, 102 . https://doi.org/10.1186/s12885-019-5295-z
BMC Cancer, Vol 19, Iss 1, Pp 1-14 (2019)
Mumin, N H, Drobnitzky, N, Patel, A, Lourenco, L M, Cahill, F F, Jiang, Y, Kong, A & Ryan, A J 2019, ' Overcoming acquired resistance to HSP90 inhibition by targeting JAK-STAT signalling in triple-negative breast cancer ', BMC Cancer, vol. 19, no. 1, 102 . https://doi.org/10.1186/s12885-019-5295-z
BMC Cancer, Vol 19, Iss 1, Pp 1-14 (2019)
Background Due to the lack of effective therapies and poor prognosis in TNBC (triple-negative breast cancer) patients, there is a strong need to develop effective novel targeted therapies for this subtype of breast cancer. Inhibition of heat shock pr
Autor:
Luiza Madia Lourenco, Anderson J. Ryan, Fiona Cahill, Neele Drobnitzky, John Moore, Yasmin Shanneik, Marcus Green, Yanyan Jiang, Agata Patel
Publikováno v:
International journal of radiation oncology, biology, physics. 100(3)
Purpose Poly (ADP-ribose) polymerase (PARP) inhibitors have been shown to enhance the radiosensitivity of cancer cells in vitro in a replication-dependent manner. Their in vivo radiosensitizing effects have also been demonstrated in preclinical tumor
Autor:
Bruno, Vaz, Marta, Popovic, Joseph A, Newman, John, Fielden, Hazel, Aitkenhead, Swagata, Halder, Abhay Narayan, Singh, Iolanda, Vendrell, Roman, Fischer, Ignacio, Torrecilla, Neele, Drobnitzky, Raimundo, Freire, David J, Amor, Paul J, Lockhart, Benedikt M, Kessler, Gillies W, McKenna, Opher, Gileadi, Kristijan, Ramadan
Publikováno v:
Molecular Cell
Summary The cytotoxicity of DNA-protein crosslinks (DPCs) is largely ascribed to their ability to block the progression of DNA replication. DPCs frequently occur in cells, either as a consequence of metabolism or exogenous agents, but the mechanism o
Autor:
Sophia X, Pfister, Enni, Markkanen, Yanyan, Jiang, Sovan, Sarkar, Mick, Woodcock, Giulia, Orlando, Ioanna, Mavrommati, Chen-Chun, Pai, Lykourgos-Panagiotis, Zalmas, Neele, Drobnitzky, Grigory L, Dianov, Clare, Verrill, Valentine M, Macaulay, Songmin, Ying, Nicholas B, La Thangue, Vincenzo, D'Angiolella, Anderson J, Ryan, Timothy C, Humphrey
Publikováno v:
Cancer cell. 28(5)
Histone H3K36 trimethylation (H3K36me3) is frequently lost in multiple cancer types, identifying it as an important therapeutic target. Here we identify a synthetic lethal interaction in which H3K36me3-deficient cancers are acutely sensitive to WEE1
Autor:
Neele Drobnitzky, Luiza Madia Lourenco, Fiona Cahill, Samantha Olyha, Sureyya Corbacioglu, Agata Patel, Anderson J. Ryan, Yanyan Jiang, Amalina Mumin
Publikováno v:
Molecular Cancer Therapeutics. 16:B30-B30
Non-small cell lung cancer (NSCLC) patients with activating mutations in the epidermal growth factor receptor (EGFR) gene generally show good responses to therapy with EGFR tyrosine kinase inhibitors (EGFR-TKIs). Unfortunately resistance emerges duri
Autor:
Songmin Ying, Anderson J. Ryan, Lykourgos-Panagiotis Zalmas, Mick Woodcock, Sophia X. Pfister, Giulia Orlando, Sovan Sarkar, Vincenzo D'Angiolella, Grigory L. Dianov, Nicholas B. La Thangue, Enni Markkanen, Timothy C. Humphrey, Yanyan Jiang, Neele Drobnitzky
Publikováno v:
Cancer Research. 76:B40-B40
Background: Loss of the histone mark H3 Lysine 36 trimethylation (H3K36me3) is highly prevalent and is associated with poor prognosis. However, there is currently no therapy targeting H3K36me3-deficient cancers. Recently we found a novel synthetic le
Autor:
Luiza Madia Lourenco, Fiona Cahill, Sivan M. Bokobza, Yanyan Jiang, Anika M. Weber, Nuramalina H. Mumin, Thomas M. Ashton, Aoife M. Devery, Anderson J. Ryan, Neele Drobnitzky
Publikováno v:
Molecular Cancer Therapeutics. 14:C114-C114
Lung cancer is the leading cause of cancer related death worldwide and adenocarcinoma is the most prevalent subtype. LKB1 (STK11) is the second most commonly altered tumour suppressor in adenocarcinoma and is inactivated in 17% of samples (1). LKB1 i
Autor:
Anderson J. Ryan, Sivan M. Bokobza, Fiona Cahill, Luiza Madia Lourenco, Neele Drobnitzky, Yanyan Jiang, Aoife Vaughan, Anthony Kong, Anika M. Weber, Nuramalina H. Mumin
Publikováno v:
Molecular Cancer Therapeutics. 14:B88-B88
Background: Triple negative breast cancer (TNBC), which accounts for 10-17% of all breast cancers, is challenging to treat due to its heterogeneity and the absence of identified targeted therapies. Heat shock protein 90 kDa (Hsp90) is a molecular cha