Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Neelam Sharma-Walia"'
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Targeted therapy is highly desirable, as it allows for selective cytotoxicity on diseased cells without off-target side effects. Nucleolin is a remarkable target for cancer therapy given its high abundance, selective presence on the plasma membrane,
Externí odkaz:
https://doaj.org/article/762b9a56688a425ba1a3c9ebc9134d49
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Cyclopentenone prostaglandins (cyPGs) are biologically active lipid mediators, including PGA2, PGA1, PGJ2, and its metabolites. cyPGs are essential regulators of inflammation, cell proliferation, apoptosis, angiogenesis, cell migration, and stem cell
Externí odkaz:
https://doaj.org/article/1cc085ebf8d0449da4c8ed29f15c4a2e
Autor:
Andrew Alsterda, Kumari Asha, Olivia Powrozek, Miroslava Repak, Sudeshna Goswami, Alexandra M. Dunn, Heidi C. Memmel, Neelam Sharma-Walia
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
The endoplasmic reticulum (ER) regulates protein folding, post-translational modifications, lipid synthesis, and calcium signaling to attenuate the accumulation of misfolded proteins causing ER stress and maintains cellular homeostasis. The tumor mic
Externí odkaz:
https://doaj.org/article/52666566898b4a6bbf590007769dd538
Targeting Host Cellular Factors as a Strategy of Therapeutic Intervention for Herpesvirus Infections
Autor:
Kumari Asha, Neelam Sharma-Walia
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
Herpesviruses utilize various host factors to establish latent infection, survival, and spread disease in the host. These factors include host cellular machinery, host proteins, gene expression, multiple transcription factors, cellular signal pathway
Externí odkaz:
https://doaj.org/article/000bb3c233454c658bcaec7d925ecd87
Publikováno v:
Frontiers in Microbiology, Vol 10 (2019)
Kaposi’s sarcoma-associated herpesvirus (KSHV) infection, particularly latent infection is often associated with inflammation. The arachidonic acid pathway, the home of several inflammation and resolution associated lipid mediators, is widely alter
Externí odkaz:
https://doaj.org/article/25accddb3b184af08a273218815e52b0
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 3, p 1042 (2021)
The hedgehog (SHH) signaling pathway is primarily involved in embryonic gut development, smooth muscle differentiation, cell proliferation, adult tissue homeostasis, tissue repair following injury, and tissue polarity during the development of verteb
Externí odkaz:
https://doaj.org/article/c9bd8372b5f04bceb30e62665f1ea2f3
Autor:
Anika Dutta, Neelam Sharma-Walia
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 3, p 644 (2019)
Lipids play a fundamental role in maintaining normal function in healthy cells. Their functions include signaling, storing energy, and acting as the central structural component of cell membranes. Alteration of lipid metabolism is a prominent feature
Externí odkaz:
https://doaj.org/article/f9a82fd7ce324ffea42ee6553725af23
Autor:
Mohanan Valiya Veettil, Dipanjan Dutta, Virginie Bottero, Chirosree Bandyopadhyay, Olsi Gjyshi, Neelam Sharma-Walia, Sujoy Dutta, Bala Chandran
Publikováno v:
PLoS Pathogens, Vol 10, Iss 10, p e1004389 (2014)
Kaposi's sarcoma associated herpesvirus (KSHV) is etiologically associated with endothelial Kaposi's sarcoma (KS) and B-cell proliferative primary effusion lymphoma (PEL), common malignancies seen in immunocompromised HIV-1 infected patients. The pro
Externí odkaz:
https://doaj.org/article/cd97af41c87c401a81fe79b2882e94b6
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e24379 (2011)
The significance of inflammation in KSHV biology and tumorigenesis prompted us to examine the role of COX-2 in primary effusion lymphoma (PEL), an aggressive AIDS-linked KSHV-associated non-Hodgkin's lymphoma (NHL) using nimesulide, a well-known COX-
Externí odkaz:
https://doaj.org/article/9eca3266df77417b8a7e2a625b133087
Autor:
Neelam Sharma-Walia, Arun George Paul, Virginie Bottero, Sathish Sadagopan, Mohanan Valiya Veettil, Nagaraj Kerur, Bala Chandran
Publikováno v:
PLoS Pathogens, Vol 6, Iss 2, p e1000777 (2010)
Kaposi's sarcoma (KS), an enigmatic endothelial cell vascular neoplasm, is characterized by the proliferation of spindle shaped endothelial cells, inflammatory cytokines (ICs), growth factors (GFs) and angiogenic factors. KSHV is etiologically linked
Externí odkaz:
https://doaj.org/article/acb4f312ec0e4c8eb54aba6804ca097a