Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Neelam Dabas Sen"'
Autor:
Shardul D. Kulkarni, Fujun Zhou, Neelam Dabas Sen, Hongen Zhang, Alan G. Hinnebusch, Jon R. Lorsch
Publikováno v:
BMC Biology, Vol 17, Iss 1, Pp 1-27 (2019)
Abstract Background Translation of an mRNA in eukaryotes starts at an AUG codon in most cases, but near-cognate codons (NCCs) such as UUG, ACG, and AUU can also be used as start sites at low levels in Saccharomyces cerevisiae. Initiation from NCCs or
Externí odkaz:
https://doaj.org/article/6bebc927b4e24df7b84f02d6436faaa8
Publikováno v:
Microorganisms, Vol 9, Iss 12, p 2413 (2021)
Ded1 is an essential DEAD-box helicase in yeast that broadly stimulates translation initiation and is critical for mRNAs with structured 5′UTRs. Recent evidence suggests that the condensation of Ded1 in mRNA granules down-regulates Ded1 function du
Externí odkaz:
https://doaj.org/article/07ede20327e64718a7ce3da36199b807
Autor:
Pilar Martin-Marcos, Fujun Zhou, Charm Karunasiri, Fan Zhang, Jinsheng Dong, Jagpreet Nanda, Shardul D Kulkarni, Neelam Dabas Sen, Mercedes Tamame, Michael Zeschnigk, Jon R Lorsch, Alan G Hinnebusch
Publikováno v:
eLife, Vol 6 (2017)
The translation pre-initiation complex (PIC) scans the mRNA for an AUG codon in favorable context, and AUG recognition stabilizes a closed PIC conformation. The unstructured N-terminal tail (NTT) of yeast eIF1A deploys five basic residues to contact
Externí odkaz:
https://doaj.org/article/7006477ad03e4f8990e1460bfec1891b
Autor:
Fujun Zhou, Alan G. Hinnebusch, Neelam Dabas Sen, Jon R. Lorsch, Hongen Zhang, Shardul D. Kulkarni
Publikováno v:
BMC Biology, Vol 17, Iss 1, Pp 1-27 (2019)
BMC Biology
BMC Biology
BackgroundTranslation of an mRNA in eukaryotes starts at AUG in most cases. Near-cognate codons (NCCs) such as UUG, ACG and AUU are also used as start sites at low levels inS. cerevisiae. Initiation from NCCs or AUGs in the 5’-untranslated regions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34df4ce7cb18cd48a16f0383133cda0c
https://doaj.org/article/6bebc927b4e24df7b84f02d6436faaa8
https://doaj.org/article/6bebc927b4e24df7b84f02d6436faaa8
Autor:
Sumit Sen, Neelam Dabas Sen
Publikováno v:
Intelligent Sustainable Systems ISBN: 9789811663680
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12e90c5384f8c6b6ccf37b61b15dd111
https://doi.org/10.1007/978-981-16-6369-7_32
https://doi.org/10.1007/978-981-16-6369-7_32
Publikováno v:
Microorganisms; Volume 9; Issue 12; Pages: 2413
Microorganisms, Vol 9, Iss 2413, p 2413 (2021)
Microorganisms
Microorganisms, Vol 9, Iss 2413, p 2413 (2021)
Microorganisms
Ded1 is an essential DEAD-box helicase in yeast that broadly stimulates translation initiation and is critical for mRNAs with structured 5′UTRs. Recent evidence suggests that the condensation of Ded1 in mRNA granules down-regulates Ded1 function du
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96b919dc999d6d001260c2bbcf2349a5
Autor:
Ross D. Hannan, Alan G. Hinnebusch, Nikolay E. Shirokikh, Thomas Preiss, Anna Herrmannová, Leoš Shivaya Valášek, Susan Wagner, Vladislava Hronová, Neelam Dabas Sen
SUMMARYTranslational control targeting mainly the initiation phase is central to the regulation of gene expression. Understanding all of its aspects requires substantial technological advancements. Here we modified yeast Translational Complex Profile
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::580ab17258d7286fcbad4a652c333d70
https://doi.org/10.1101/806125
https://doi.org/10.1101/806125
Autor:
Neelam Dabas Sen, Thomas Preiss, Neha Gupta, Stuart K. Archer, Alan G. Hinnebusch, Jon R. Lorsch
Publikováno v:
Nucleic Acids Research.
RNA structures that impede ribosome binding or subsequent scanning of the 5′-untranslated region (5′-UTR) for the AUG initiation codon reduce translation efficiency. Yeast DEAD-box RNA helicase Ded1 appears to promote translation by resolving 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b399ea6e8419fe8cfe92c4a1563685a
https://doi.org/10.1093/nar/gkz595
https://doi.org/10.1093/nar/gkz595
Publikováno v:
Proceedings of the National Academy of Sciences. 113:10464-10472
DEAD-box RNA helicases eukaryotic translation initiation factor 4A (eIF4A) and Ded1 promote translation by resolving mRNA secondary structures that impede preinitiation complex (PIC) attachment to mRNA or scanning. Eukaryotic translation initiation f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::796d751d7998d0e9f86ab8bef81bbc3e
https://doi.org/10.1073/pnas.1612398113
https://doi.org/10.1073/pnas.1612398113
Autor:
Ross D. Hannan, Anna Herrmannová, Nikolay E. Shirokikh, Thomas Preiss, Stanislava Gunišová, Susan Wagner, Leoš Shivaya Valášek, Alan G. Hinnebusch, Vladislava Hronová, Neelam Dabas Sen
Publikováno v:
Molecular Cell
Summary Translational control targeting the initiation phase is central to the regulation of gene expression. Understanding all of its aspects requires substantial technological advancements. Here we modified yeast translation complex profile sequenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cdf25659f1966dc17938ae4216d581b
http://europepmc.org/articles/PMC7447980
http://europepmc.org/articles/PMC7447980