Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Neelam Bodhale"'
Autor:
Abdollah Jafarzadeh, Maryam Nemati, Najmeh Aminizadeh, Neelam Bodhale, Arup Sarkar, Sara Jafarzadeh, Iraj Sharifi, Bhaskar Saha
Publikováno v:
PLoS Pathogens, Vol 18, Iss 8 (2022)
As effector innate immune cells and as a host to the protozoan parasite Leishmania, macrophages play a dual role in antileishmanial immunoregulation. The 2 key players in this immunoregulation are the macrophage-expressed microRNAs (miRNAs) and the m
Externí odkaz:
https://doaj.org/article/a12abbcf155446b6b7901c786c51f5f9
Autor:
Inês Mesquita, Carolina Ferreira, Diana Moreira, George Eduardo Gabriel Kluck, Ana Margarida Barbosa, Egídio Torrado, Ricardo Jorge Dinis-Oliveira, Luís Gafeira Gonçalves, Charles-Joly Beauparlant, Arnaud Droit, Luciana Berod, Tim Sparwasser, Neelam Bodhale, Bhaskar Saha, Fernando Rodrigues, Cristina Cunha, Agostinho Carvalho, António Gil Castro, Jérôme Estaquier, Ricardo Silvestre
Publikováno v:
Cell Reports, Vol 30, Iss 12, Pp 4052-4064.e7 (2020)
Summary: Hypoxia-inducible factor-1 alpha (HIF-1α) is considered a global regulator of cellular metabolism and innate immune cell functions. Intracellular pathogens such as Leishmania have been reported to manipulate host cell metabolism. Herein, we
Externí odkaz:
https://doaj.org/article/56188c20c83a4ffcb7e3271e23a039b1
Publikováno v:
European Journal of Immunology.
Autor:
Bhaskar Saha, Arup Sarkar, Surajit Bhattacharjee, Uddipan Sarma, Ashok Patidar, Himanshu Singh Chandel, Surya Prakash Pandey, Thomas Ebensen, Prashant Chauhan, Neelam Bodhale, Ricardo Silvestre, Divanshu Shukla, Carlos Guzmán, Soumya Kanti Ghosh
Publikováno v:
Immunology
Multiple pathogen-associated molecular patterns (PAMPs) on a pathogen's surface imply their simultaneous recognition by the host cell membrane-located multiple PAMP-specific Toll-Like Receptors (TLRs). The TLRs on endosomes recognize internalized pat
Publikováno v:
Cytokine. 157
IFN-γ, a type 2 interferon and a cytokine, is critical for both innate and adaptive immunity. IFN-γ binds to the IFN-γRs on the cell membrane of macrophages, signals through JAK1-STAT-1 pathway and induces IFN-γ-stimulated genes (ISGs). As Leishm
Autor:
Mukesh Kumar Jha, Surya Prakash Pandey, Neelam Bodhale, Bhaskar Saha, Abdur Rub, Arup Sarkar, Ricardo Silvestre, Aditya Y. Sarode, Debasri Mukherjee, Neetu Srivastava
Publikováno v:
The Journal of Immunology. 204:2734-2753
Leishmania major causes cutaneous leishmaniasis. An antileishmanial vaccine for humans is unavailable. In this study, we report development of two attenuated L. major strains—5ASKH-HP and LV39-HP—by continuous culture (high passage) of the corres
Autor:
Abdollah Jafarzadeh, Sunil Kumar, Neelam Bodhale, Sara Jafarzadeh, Maryam Nemati, Iraj Sharifi, Arup Sarkar, Bhaskar Saha
Publikováno v:
Cytokine. 153
The expression of programmed cell death protein-1 (PD-1) and its ligands- PD-L1 and PD-L2- on T cells and macrophages', respectively, increases in Leishmania infection. The PD-1/PD-L1 interaction induces T cell anergy, T cell apoptosis and exhaustion
Autor:
Tejaswini Patil, Arup Sarkar, Vasundhara More, Ashok Patidar, Arkajyoti Mukherjee, David M. Mosser, Rahul Suresh, Deepti Rane, Jagneshwar Dandapat, Neelam Bodhale
Publikováno v:
Cytokine. 112:27-31
Leishmania is an obligate intracellular parasite uses low pH phagolysosomal compartments of host macrophages as their final abode. IL-1β is a pro inflammatory cytokine, which is secreted by immune cells to trigger inflammation and this has been foun
Autor:
Arkajyoti Mukherjee, Jagneswar Dandapat, Sayoni Roy, Bhaskar Saha, Ashok Patidar, Arup Sarkar, Neelam Bodhale
Publikováno v:
Immunology
Of the thirteen Toll‐like receptors (TLRs) in mice, TLR2 has a unique ability of forming heterodimers with TLR1 and TLR6. Such associations lead to selective cellular signalling and cellular responses such as cytokine expression. One of the signall
Autor:
Baibaswata Saha, Arup Sarkar, Neelam Bodhale, Renuka Bhor, Kalpana Pai, Surajit Bhattacharjee
Publikováno v:
Cytokine. 145
Parasites of the genus Leishmania cause the disease leishmaniasis. As the sandfly vector transfers the promastigotes into the skin of the human host, the infection is either cured or exacerbated. In the process, there emerge several unsolved paradoxe