Výsledky vyhledávání - "Neelam, Sarode"

Discovery of 5-(2-chloro-4′-(1H-imidazol-1-yl)-[1,1′-biphenyl]-4-yl)-1H-tetrazole as potent and orally efficacious S-nitrosoglutathione reductase (GSNOR) inhibitors for the potential treatment of COPD

Autor: Satyawan Jadhav, Sanjay Deshmukh, Siddharth Mhatre, Abhay Kulkarni, Shital Tondlekar, Samitabh Chakraborti, Nagarajan Muthukaman, Macchindra Tambe, Dnyandeo Pisal, Vikram Mansingh Bhosale, Neelam Sarode, Daisy Manish Shah, Mahamad Yunnus A. Mahat, Girish S. Gudi, Neelima Khairatkar-Joshi, Laxmikant Atmaram Gharat

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 28:3766-3773

Endogenous nitrosothiols (SNOs) including S-nitrosoglutathione (GSNO) serve as reservoir for bioavailable nitric oxide (NO) and mediate NO-based signaling, inflammatory status and smooth muscle function in the lung. GSNOR inhibition increases pulmona

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e69f3548323ec6b3cb510c32ec44b9f3
https://doi.org/10.1016/j.bmcl.2018.10.012

Zobrazit plný text záznamu

Discovery of furan and dihydrofuran-fused tricyclic benzo[ d ]imidazole derivatives as potent and orally efficacious microsomal prostaglandin E synthase-1 (mPGES-1) inhibitors: Part-1

Autor: Vidya Ganapati Kattige, Srinivasa Honnegowda, Sanjay Deshmukh, Laxmikant Atmaram Gharat, Abhay Kulkarni, Neelam Sarode, Pooja Sawant, Shital Tondlekar, Neelima Khairatkar-Joshi, Vikas Karande, Dnyandeo Pisal, Satyawan Jadhav, Macchindra Tambe, Nagarajan Muthukaman, Mahamadhanif S. Shaikh, Ramchandra R. Sangana, Monali Pisat, Girish S. Gudi, Dayanidhi Behera

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 27:5131-5138

This letter describes the synthesis and biological evaluation of furan and dihydrofuran-fused tricyclic benzo[d]imidazole derivatives as novel mPGES-1 inhibitors, capable of inhibiting an increased PGE2 production in the disease state. Structure-acti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c711ec94b372ec3592b14b193fefd59c
https://doi.org/10.1016/j.bmcl.2017.10.062

Zobrazit plný text záznamu

Tricyclic 4,4-dimethyl-3,4-dihydrochromeno[3,4- d ]imidazole derivatives as microsomal prostaglandin E 2 synthase-1 (mPGES-1) inhibitors: SAR and in vivo efficacy in hyperalgesia pain model

Autor: Srinivasa Honnegowda, Shital Tondlekar, Dnyandeo Pisal, Abhay Kulkarni, Dayanidhi Behera, Girish S. Gudi, Laxmikant Atmaram Gharat, Macchindra Tambe, Nagarajan Muthukaman, Sanjay Deshmukh, Satyawan Jadhav, Jitendra Maganbhai Gajera, Neelam Sarode, Mahamadhanif S. Shaikh, Vikas Karande, Lakshminarayana Narayana, Vidya Ganapati Kattige, Neelima Khairatkar-Joshi

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 27:2594-2601

A series of substituted tricyclic 4,4-dimethyl-3,4-dihydrochromeno[3,4-d]imidazole derivatives have been synthesized and their mPGES-1 biological activity has been disclosed in detail. Structure-activity relationship (SAR) optimization provided inhib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4c3194769e93c1e5b342652115b63fe7
https://doi.org/10.1016/j.bmcl.2017.03.068

Zobrazit plný text záznamu

Discovery of 2-((2-chloro-6-fluorophenyl)amino)- N -(3-fluoro-5-(trifluoromethyl)phenyl)-1-methyl-7,8-dihydro-1 H -[1,4]dioxino[2′,3′:3,4]benzo[1,2- d ]imidazole-5-carboxamide as potent, selective and efficacious microsomal prostaglandin E 2 synthase-1 (mPGES-1) inhibitor

Autor: Satyawan Jadhav, Mahamadhanif S. Shaikh, Abhay Kulkarni, Mahamad Yunnus A. Mahat, Nagarajan Muthukaman, Srinivasa Honnegowda, Vidya Ganapati Kattige, Laxmikant Atmaram Gharat, Vikas Karande, Shital Tondlekar, Dnyandeo Pisal, Macchindra Tambe, Neelima Khairatkar-Joshi, Girish S. Gudi, Neelam Sarode, Sanjay Deshmukh

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 26:5977-5984

The discovery and SAR of potent, selective dioxane-fused tricyclic benz[ d ]imidazole derivatives as mPGES-1 inhibitor are herein described. Various amide modifications in this series afforded many potent mPGES-1 inhibitors, of which 17d proved to be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::74aee3215b596ce6b0bc05c3c26d7a00
https://doi.org/10.1016/j.bmcl.2016.10.079

Zobrazit plný text záznamu

Alleviating CYP and hERG liabilities by structure optimization of dihydrofuran-fused tricyclic benzo[d]imidazole series - Potent, selective and orally efficacious microsomal prostaglandin E synthase-1 (mPGES-1) inhibitors: Part-2

Autor: Nagarajan Muthukaman, Pooja Sawant, Dnyandeo Pisal, Srinivasa Honnegowda, Abhay Kulkarni, Vidya Ganapati Kattige, Sanjay Deshmukh, Shital Tondlekar, Neelam Sarode, Satyawan Jadhav, Neelima Khairatkar-Joshi, Dayanidhi Behera, Girish S. Gudi, Ramchandra R. Sangana, Vikas Karande, Macchindra Tambe, Monali Pisat, Mahamadhanif S. Shaikh, Laxmikant Atmaram Gharat

Publikováno v: Bioorganicmedicinal chemistry letters. 28(7)

In an effort to identify CYP and hERG clean mPGES-1 inhibitors from the dihydrofuran-fused tricyclic benzo[d]imidazole series lead 7, an extensive structure-activity relationship (SAR) studies were performed. Optimization of A, D and E-rings in 7 aff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa34d823475ba2b669394baf70bf1665
https://pubmed.ncbi.nlm.nih.gov/29519738

Zobrazit plný text záznamu

Tricyclic 4,4-dimethyl-3,4-dihydrochromeno[3,4-d]imidazole derivatives as microsomal prostaglandin E

Autor: Nagarajan, Muthukaman, Macchindra, Tambe, Mahamadhanif, Shaikh, Dnyandeo, Pisal, Sanjay, Deshmukh, Shital, Tondlekar, Neelam, Sarode, Lakshminarayana, Narayana, Jitendra M, Gajera, Vidya G, Kattige, Srinivasa, Honnegowda, Vikas, Karande, Abhay, Kulkarni, Dayanidhi, Behera, Satyawan B, Jadhav, Girish S, Gudi, Neelima, Khairatkar-Joshi, Laxmikant A, Gharat

Publikováno v: Bioorganicmedicinal chemistry letters. 27(11)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9874f5bf5efea64e8794baffe42a441c
https://pubmed.ncbi.nlm.nih.gov/28400234

Zobrazit plný text záznamu

Discovery of 2-((2-chloro-6-fluorophenyl)amino)-N-(3-fluoro-5-(trifluoromethyl)phenyl)-1-methyl-7,8-dihydro-1H-[1,4]dioxino[2',3':3,4]benzo[1,2-d]imidazole-5-carboxamide as potent, selective and efficacious microsomal prostaglandin E

Autor: Nagarajan, Muthukaman, Sanjay, Deshmukh, Neelam, Sarode, Shital, Tondlekar, Macchindra, Tambe, Dnyandeo, Pisal, Mahamadhanif, Shaikh, Vidya G, Kattige, Srinivasa, Honnegowda, Vikas, Karande, Abhay, Kulkarni, Satyawan B, Jadhav, Mahamad Yunnus A, Mahat, Girish S, Gudi, Neelima, Khairatkar-Joshi, Laxmikant A, Gharat

Publikováno v: Bioorganicmedicinal chemistry letters. 26(24)

The discovery and SAR of potent, selective dioxane-fused tricyclic benz[d]imidazole derivatives as mPGES-1 inhibitor are herein described. Various amide modifications in this series afforded many potent mPGES-1 inhibitors, of which 17d proved to be s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bd13d730eff612038af486251a9056a6
https://pubmed.ncbi.nlm.nih.gov/27865703

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání