Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Neel M. Fofaria"'
Publikováno v:
Proceedings, Vol 1, Iss 10, p 981 (2017)
Malignant melanoma is significant problem for Caucasian population in the western countries. Mutations in BRAF gene in 60% of patients is responsible for developing resistance to BRAF inhibitors. Our results delineated the mechanism of resistance and
Externí odkaz:
https://doaj.org/article/4573bed945e34af9aff55aff89567da0
Publikováno v:
Cancer Letters. 442:68-81
Breast cancer metastasis is a multi-step process and requires cells to overcome anoikis. Anoikis is defined as cell-death that occurs due to loss of cell adhesion. During the course of cancer progression, tumor cells acquire resistance to anoikis. Ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7a02d55264c04f0008189a262170ce9
https://doi.org/10.1016/j.canlet.2018.10.021
https://doi.org/10.1016/j.canlet.2018.10.021
Autor:
Dennie T. Frederick, Keith T. Flaherty, Neel M. Fofaria, Ryan J. Sullivan, Sanjay K. Srivastava
Publikováno v:
Oncotarget
Melanoma harboring BRAF mutations frequently develop resistance to BRAF inhibitors, limiting the impact of treatment. Here, we establish a mechanism of resistance and subsequently identified a suitable drug combination to overcome the resistance. Sin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85749404d19fa7b90acb53495674f2c5
https://doi.org/10.18632/oncotarget.5755
https://doi.org/10.18632/oncotarget.5755
Publikováno v:
Chinese Journal of Natural Medicines. 13:730-742
Cancer is generally regarded as the result of abnormal growth of cells. According to World Health Organization, cancer is the leading cause of mortality worldwide. Mother nature provides a large source of bioactive compounds with excellent therapeuti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b66f4189640d77bdec21a068c44da6e
https://doi.org/10.1016/s1875-5364(15)30073-x
https://doi.org/10.1016/s1875-5364(15)30073-x
Autor:
Sung-Hoon Kim, Neel M. Fofaria, Sanjay K. Srivastava, Parul Gupta, Alok Ranjan, Kartick C. Pramanik
Publikováno v:
Oncotarget
// Kartick C. Pramanik 1 , Neel M. Fofaria 1 , Parul Gupta 1 , Alok Ranjan 1 , Sung-Hoon Kim 2 , Sanjay K. Srivastava 1, 2 1 Department of Biomedical Sciences and Cancer Biology Center, Texas Tech University Health Sciences Center, Amarillo, TX 79106
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04b8e1a9904949f15d4740c063cade46
http://europepmc.org/articles/PMC4484476
http://europepmc.org/articles/PMC4484476
Autor:
Sanjay K. Srivastava, Neel M. Fofaria
Publikováno v:
Carcinogenesis. 36:142-150
Tumor cells need to attain anoikis resistance to survive prior to metastasis making it a vital trait of malignancy. The mechanism by which pancreatic cancer cells resist anoikis and metastasize is not well established. Significant proportion of pancr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b65f1284334a69655605803033f62e3b
https://doi.org/10.1093/carcin/bgu233
https://doi.org/10.1093/carcin/bgu233
Autor:
Sanjay K. Srivastava, Neel M. Fofaria
Publikováno v:
Oncotarget
Anoikis is an anchorage-independent cell death. Resistance to anoikis is one of the key features of metastatic cells. Here, we analyzed the role of STAT3 in anoikis resistance in melanoma cells leading to metastasis. When grown under anchorage-indepe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de80e8b89cf43b2279b6857e95bf8c79
https://doi.org/10.18632/oncotarget.2251
https://doi.org/10.18632/oncotarget.2251
Publikováno v:
Molecular Cancer Therapeutics. 13:687-698
Here, we investigated the potential mechanism of capsaicin-mediated apoptosis in pancreatic cancer cells. Capsaicin treatment phosphorylated c-jun-NH2-kinase (JNK); forkhead box transcription factor, class O (FOXO1); and BIM in BxPC-3, AsPC-1, and L3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03e714d9b5198ad1897c950208e2cb87
https://doi.org/10.1158/1535-7163.mct-13-0863
https://doi.org/10.1158/1535-7163.mct-13-0863
Publikováno v:
Cancer Research. 78:3518-3518
Tumor cell metabolism is a hallmark of chemoresistance and its role has been well-defined in BRAF inhibitor resistance in melanoma. Melanoma cells are highly proliferative and are shown to develop addiction towards the metabolic pathways like glycoly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a98428602bf59f95da00b2c67f8df75
https://doi.org/10.1158/1538-7445.am2018-3518
https://doi.org/10.1158/1538-7445.am2018-3518
Publikováno v:
The Enzymes. 37
Cancer results from aberrant signaling pathways that result in uncontrolled cellular proliferation. The epidemiological studies have shown a strong inverse correlation between dietary consumption of cruciferous vegetables and incidences of cancer. Is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a01d8a2f2fefde8e340a7e508a9c2406
https://pubmed.ncbi.nlm.nih.gov/26298458
https://pubmed.ncbi.nlm.nih.gov/26298458