Metabolic engineering of yeast for de novo production of kratom monoterpene indole alkaloids.

Autor: Holtz M; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kgs. Lyngby, Denmark., Rago D; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kgs. Lyngby, Denmark., Nedermark I; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kgs. Lyngby, Denmark., Hansson FG; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kgs. Lyngby, Denmark., Lehka BJ; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kgs. Lyngby, Denmark., Hansen LG; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kgs. Lyngby, Denmark., Marcussen NEJ; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kgs. Lyngby, Denmark., Veneman WJ; Future Genomics Technologies, Leiden, 2333 BE, the Netherlands., Ahonen L; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kgs. Lyngby, Denmark., Wungsintaweekul J; Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat Yai Campus, 90112, Songkhla, Thailand., Acevedo-Rocha CG; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kgs. Lyngby, Denmark., Dirks RP; Future Genomics Technologies, Leiden, 2333 BE, the Netherlands., Zhang J; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kgs. Lyngby, Denmark., Keasling JD; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kgs. Lyngby, Denmark; Joint BioEnergy Institute, Emeryville, CA, USA; Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA; Department of Chemical and Biomolecular Engineering, Department of Bioengineering, University of California, Berkeley, CA, USA. Electronic address: keasling@berkeley.edu., Jensen MK; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kgs. Lyngby, Denmark. Electronic address: mije@biosustain.dtu.dk.

Publikováno v: Metabolic engineering [Metab Eng] 2024 Nov; Vol. 86, pp. 135-146. Date of Electronic Publication: 2024 Oct 02.