Intestinal B-cells license metabolic T-cell activation in NASH microbiota/antigen-independently and contribute to fibrosis by IgA-FcR signalling

Autor: Elena Kotsiliti, Valentina Leone, Svenja Schuehle, Olivier Govaere, Hai Li, Monika J. Wolf, Helena Horvatic, Sandra Bierwirth, Jana Hundertmark, Donato Inverso, Laimdota Zizmare, Avital Sarusi-Portuguez, Revant Gupta, Tracy O’Connor, Anastasios D. Giannou, Ahmad Mustafa Shiri, Yehuda Schlesinger, Maria Garcia Beccaria, Charlotte Rennert, Dominik Pfister, Rupert Öllinger, Iana Gadjalova, Pierluigi Ramadori, Mohammad Rahbari, Nuh Rahbari, Marc Healy, Mirian Fernández-Vaquero, Neda Yahoo, Jakob Janzen, Indrabahadur Singh, Chaofan Fan, Xinyuan Liu, Monika Rau, Martin Feuchtenberger, Eva Schwaneck, Sebastian J. Wallace, Simon Cockell, John Wilson-Kanamori, Prakash Ramachandran, Celia Kho, Timothy J. Kendall, Anne-Laure Leblond, Selina J. Keppler, Piotr Bielecki, Katja Steiger, Maike Hofmann, Karsten Rippe, Horst Zitzlesberger, Achim Weber, Nisar Malek, Tom Lüdde, Mihael Vucur, Hellmut G. Augustin, Richard Flavell, Oren Parnas, Roland Rad, Olivier Pabst, Neil C. Henderson, Samuel Huber, Andrew Macpherson, Percy Knolle, Manfred Claasen, Andreas Geier, Christoph Trautwein, Kristian Unger, Eran Elinav, Ari Waisman, Zeinab Abdullah, Dirk Haller, Frank Tacke, Quentin M. Anstee, Mathias Heikenwalder

Publikováno v: Kotsiliti, E, Leone, V, Schuehle, S, Govaere, O, Li, H, Wolf, M J, Horvatic, H, Bierwirth, S, Hundertmark, J, Inverso, D, Zizmare, L, Sarusi-Portuguez, A, Gupta, R, O'Connor, T, Giannou, A D, Shiri, A M, Schlesinger, Y, Beccaria, M G, Rennert, C, Pfister, D, Öllinger, R, Gadjalova, I, Ramadori, P, Rahbari, M, Rahbari, N, Healy, M, Fernández-Vaquero, M, Yahoo, N, Janzen, J, Singh, I, Fan, C, Liu, X, Rau, M, Feuchtenberger, M, Schwaneck, E, Wallace, S J, Cockell, S, Wilson-Kanamori, J, Ramachandran, P, Kho, C, Kendall, T J, Leblond, A-L, Keppler, S J, Bielecki, P, Steiger, K, Hofmann, M, Rippe, K, Zitzlesberger, H, Weber, A, Malek, N, Lüdde, T, Vucur, M, Augustin, H G, Flavell, R, Parnas, O, Rad, R, Pabst, O, Henderson, N C, Huber, S, Macpherson, A, Knolle, P, Claasen, M, Geier, A, Trautwein, C, Unger, K, Elinav, E, Waisman, A, Abdullah, Z, Haller, D, Tacke, F, Anstee, Q M & Heikenwalder, M 2023, ' Intestinal B-cells license metabolic T-cell activation in NASH microbiota/antigen-independently and contribute to fibrosis by IgA-FcR signalling ', Journal of Hepatology . https://doi.org/10.1016/j.jhep.2023.04.037

BACKGROUND & AIMS: The progression of nonalcoholic steatohepatitis (NASH) to fibrosis and hepatocellular carcinoma (HCC) is aggravated by auto-aggressive T cells. The gut-liver axis contributes to NASH, but the mechanisms involved and the consequence

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40e25f605ee9738f8f6026a70bbfe8ba

Forced expression of Hnf1b/Foxa3 promotes hepatic fate of embryonic stem cells

Autor: Jalal Rostamzadeh, Asghar Ebadifar, Fardin Fathi, Mohammad Saeed Hakhamaneshi, Hossein Baharvand, Behshad Pournasr, Neda Yahoo

Publikováno v: Biochemical and Biophysical Research Communications. 474:199-205

Embryonic stem (ES) cell-derived hepatocytes have the potential to be used for basic research, regenerative medicine, and drug discovery. Recent reports demonstrated that in addition to conventional differentiation inducers such as chemical compounds

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5190e2a2dd39cdb3d26be7f40241a766
https://doi.org/10.1016/j.bbrc.2016.04.102