Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Ned Braunstein"'
Autor:
Mohamed A. Kamal, Matthew P. Kosloski, Ching-Ha Lai, Michael A. Partridge, Manoj Rajadhyaksha, Vanaja Kanamaluru, Ashish Bansal, Arsalan Shabbir, Brad Shumel, Marius Ardeleanu, Susan M. Richards, Hong Yan, Christine R. Xu, Ainara Rodríguez-Marco, Jing Xiao, Faisal A. Khokhar, Guy Gherardi, Elisa Babilonia, Jennifer Maloney, Eric Mortensen, Bolanle Akinlade, Ned Braunstein, Neil Stahl, Albert Torri, John D. Davis, A. Thomas DiCioccio
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundDevelopment of anti-drug antibodies (ADAs) and neutralizing antibodies (NAbs) to monoclonal antibodies may adversely impact pharmacokinetics, efficacy, and/or safety.ObjectiveTo describe incidence, titer, and persistence of dupilumab ADAs a
Externí odkaz:
https://doaj.org/article/261ac4e1c27146febf714be3ad3c22c4
Autor:
Jing Xiao, Paula Dakin, Gregory P Geba, Edward Cox, Rafia Bhore, Jennifer D Hamilton, Shazia Ali, Yogesh Patel, Thomas D Norton, Mazhar Thakur, Samit Ganguly, Jesse Chao, Alpana Waldron, Kenneth C Turner, John D Davis, Susan C Irvin, Cynthia Pan, Dominique Atmodjo-Watkins, Andrea T Hooper, Danise Subramaniam, Joseph A Bocchini, Bari Kowal, A. Thomas DiCioccio, Ned Braunstein, Gary A Herman
Publikováno v:
BMJ Open, Vol 14, Iss 10 (2024)
Objective Pregnant women with COVID-19 are at elevated risk for severe outcomes, but clinical data on management of these patients are limited. Monoclonal antibodies, such as casirivimab plus imdevimab (CAS+IMD), have proven effective in treating non
Externí odkaz:
https://doaj.org/article/b7231e34caf546898029db8ba1527a60
Autor:
Flonza Isa, Eduardo Forleo-Neto, Jonathan Meyer, Wenjun Zheng, Scott Rasmussen, Danielle Armas, Masaru Oshita, Cynthia Brinson, Steven Folkerth, Lori Faria, Ingeborg Heirman, Neena Sarkar, Bret J. Musser, Shikha Bansal, Meagan P. O'Brien, Kenneth C. Turner, Samit Ganguly, Adnan Mahmood, Ajla Dupljak, Andrea T. Hooper, Jennifer D. Hamilton, Yunji Kim, Bari Kowal, Yuhwen Soo, Gregory P. Geba, Leah Lipsich, Ned Braunstein, George D. Yancopoulos, David M. Weinreich, Gary A. Herman
Publikováno v:
International Journal of Infectious Diseases, Vol 122, Iss , Pp 585-592 (2022)
Objectives: A phase 1, double-blind, placebo-controlled trial was conducted to evaluate the safety, tolerability, and exploratory efficacy of repeat monthly doses of subcutaneous (SC) casirivimab and imdevimab (CAS+IMD) in uninfected adult volunteers
Externí odkaz:
https://doaj.org/article/2e38e7074cf04400bb5312a6c93e1302
Autor:
Gary A Herman, Meagan P O'Brien, Eduardo Forleo-Neto, Neena Sarkar, Flonza Isa, Peijie Hou, Kuo-Chen Chan, Katharine J Bar, Ruanne V Barnabas, Dan H Barouch, Myron S Cohen, Christopher B Hurt, Dale R Burwen, Mary A Marovich, Bret J Musser, John D Davis, Kenneth C Turner, Adnan Mahmood, Andrea T Hooper, Jennifer D Hamilton, Janie Parrino, Danise Subramaniam, Alina Baum, Christos A Kyratsous, A Thomas DiCioccio, Neil Stahl, Ned Braunstein, George D Yancopoulos, David M Weinreich, Achint Chani, Adebiyi Adepoju, Aisha Mortagy, Ajla Dupljak, Alison Brown, Amy Froment, Andrea Hooper, Andrea Margiotta, Andrew Bombardier, Anita Islam, Anne Smith, Arvinder Dhillon, Audra McMillian, Aurora Breazna, Ayesha Aslam, Barabara Carpentino, Bari Kowal, Barry Siliverstein, Benjamin Horel, Bo Zhu, Bret Musser, Brian Bush, Brian Head, Brian Snow, Bryan Zhu, Camille Debray, Careta Phillips, Carmella Simiele, Carol Lee, Carolyn Nienstedt, Caryn Trbovic, Casey (Kuo-Chen) Chan, Catherine Elliott, Chad Fish, Charlie Ni, Christa Polidori, Christine Enciso, Christopher Caira, Christopher Powell, Christos A. Kyratsous, Cliff Baum, Colin McDonald, Cynthia Leigh, Cynthia Pan, Dana Wolken, Danielle Manganello, David Liu, David Stein, David M. Weinreich, Dawlat Hassan, Daya Gulabani, Deborah Fix, Deborah Leonard, Deepshree Sarda, Denise Bonhomme, Denise Kennedy, Devin Darcy, Dhanalakshmi Barron, Diana Hughes, Diana Rofail, Dipinder Kaur, Divya Ramesh, Dona Bianco, Donna Cohen, Edward Jean-Baptiste, Ehsan Bukhari, Eileen Doyle, Elizabeth Bucknam, Emily Labriola-Tomkins, Emily Nanna, Esther Huffman O'Keefe, Evelyn Gasparino, Evonne Fung, Fung-Yee To, Gary Herman, George D. Yancopoulos, Georgia Bellingham, Giane Sumner, Grainne Moggan, Grainne Power, Haixia Zeng, Hazel Mariveles, Heath Gonzalez, Helen Kang, Hibo Noor, Ian Minns, Ingeborg Heirman, Izabella Peszek, James Donohue, Jamie Rusconi, Janice Austin, Jeannie Yo, Jenna McDonnell, Jennifer D. Hamilton, Jessica Boarder, Jianguo Wei, Jingchun Yu, Joanne Malia, Joanne Tucciarone, Jodie Tyler-Gale, John D. Davis, John Strein, Jonathan Cohen, Jonathan Meyer, Jordan Ursino, Joseph Im, Joseph Tramaglini, Joseph Wolken, Kaitlyn Potter, Kaitlyn Scacalossi, Kamala Naidu, Karen Browning, Karen Rutkowski, Karen Yau, Katherine Woloshin, Kelly Lewis-Amezcua, Kenneth Turner, Kimberly Dornheim, Kit Chiu, Kosalai Mohan, Kristina McGuire, Kristy Macci, Kurt Ringleben, Kusha Mohammadi, Kyle Foster, Latora Knighton, Leah Lipsich, Lindsay Darling, Lisa Boersma, Lisa Cowen, Lisa Hersh, Lisa Jackson, Lisa Purcell, Lisa Sherpinsky, Livia Lai, Lori Faria, Lori Geissler, Louise Boppert, Lyra Fiske, Marc Dickens, Marco Mancini, Maria C. Leigh, Meagan P. O'Brien, Michael Batchelder, Michael Klinger, Michael Partridge, Michel Tarabocchia, Michelle Wong, Mivianisse Rodriguez, Moetaz Albizem, Muriel O'Byrne, Nicole Deitz, Nicole Memblatt, Nirav Shah, Nitin Kumar, Olga Herrera, Oluchi Adedoyin, Ori Yellin, Pamela Snodgrass, Patrick Floody, Paul D'Ambrosio, Paul (Xiaobang) Gao, Philippa Hearld, Qin Li, Rachel Kitchenoff, Rakiyya Ali, Ramya Iyer, Ravikanth Chava, Rinol Alaj, Rita Pedraza, Robert Hamlin, Romana Hosain, Ruchin Gorawala, Ryan White, Ryan Yu, Rylee Fogarty, S. Balachandra Dass, Sagarika Bollini, Samit Ganguly, Sandra DeCicco, Sanket Patel, Sarah Cassimaty, Selin Somersan-Karakaya, Shane McCarthy, Sharon Henkel, Shazia Ali, Shelley Geila Shapiro, Somang Kim, Soraya Nossoughi, Stephanie Bisulco, Steven Elkin, Steven Long, Sumathi Sivapalasingam, Susan Irvin, Susan Wilt, Tami Min, Tatiana Constant, Theresa Devins, Thomas DiCioccio, Thomas Norton, Travis Bernardo, Tzu-Chien Chuang, Victor (Jianguo) Wei, Vinh Nuce, Vishnu Battini, Wilson Caldwell, Xiaobang Gao, Xin Chen, Yanmei Tian, Yasmin Khan, Yuming Zhao, Yunji Kim, Bonnie Dye, Christopher B. Hurt, Dale R. Burwen, Dan H. Barouch, David Burns, Elizabeth Brown, Katharine J. Bar, Mary Marovich, Meredith Clement, Myron S. Cohen, Nirupama Sista, Ruanne V. Barnabas, Sheryl Zwerski
Publikováno v:
The Lancet Infectious Diseases. 22:1444-1454
There is an unmet need for COVID-19 prevention in patient populations who have not mounted or are not expected to mount an adequate immune response to complete COVID-19 vaccination. We previously reported that a single subcutaneous 1200 mg dose of th
Autor:
David, Stein, Ernesto, Oviedo-Orta, Wendy A, Kampman, Jennifer, McGinniss, George, Betts, Margaret, McDermott, Beth, Holly, Johnathan M, Lancaster, Ned, Braunstein, George D, Yancopoulos, David M, Weinreich
Publikováno v:
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Background Patients with immunodeficiency-associated antibody disorders are at a higher risk of prolonged/persistent COVID-19 infection, having no viable treatment options. Methods A retrospective analysis of patients with primary and/or secondary im
Autor:
David M, Weinreich, Sumathi, Sivapalasingam, Thomas, Norton, Shazia, Ali, Haitao, Gao, Rafia, Bhore, Bret J, Musser, Yuhwen, Soo, Diana, Rofail, Joseph, Im, Christina, Perry, Cynthia, Pan, Romana, Hosain, Adnan, Mahmood, John D, Davis, Kenneth C, Turner, Andrea T, Hooper, Jennifer D, Hamilton, Alina, Baum, Christos A, Kyratsous, Yunji, Kim, Amanda, Cook, Wendy, Kampman, Anita, Kohli, Yessica, Sachdeva, Ximena, Graber, Bari, Kowal, Thomas, DiCioccio, Neil, Stahl, Leah, Lipsich, Ned, Braunstein, Gary, Herman, George D, Yancopoulos, Yasmin, Khan
Publikováno v:
The New England Journal of Medicine
New England Journal of Medicine
New England Journal of Medicine
Background Recent data suggest that complications and death from coronavirus disease 2019 (Covid-19) may be related to high viral loads. Methods In this ongoing, double-blind, phase 1–3 trial involving nonhospitalized patients with Covid-19, we inv
Autor:
Meagan P, O'Brien, Eduardo, Forleo-Neto, Neena, Sarkar, Flonza, Isa, Peijie, Hou, Kuo-Chen, Chan, Bret J, Musser, Katharine J, Bar, Ruanne V, Barnabas, Dan H, Barouch, Myron S, Cohen, Christopher B, Hurt, Dale R, Burwen, Mary A, Marovich, Elizabeth R, Brown, Ingeborg, Heirman, John D, Davis, Kenneth C, Turner, Divya, Ramesh, Adnan, Mahmood, Andrea T, Hooper, Jennifer D, Hamilton, Yunji, Kim, Lisa A, Purcell, Alina, Baum, Christos A, Kyratsous, James, Krainson, Richard, Perez-Perez, Rizwana, Mohseni, Bari, Kowal, A Thomas, DiCioccio, Gregory P, Geba, Neil, Stahl, Leah, Lipsich, Ned, Braunstein, Gary, Herman, George D, Yancopoulos, David M, Weinreich, Anya T., Weerasinghe
Publikováno v:
JAMA
IMPORTANCE: Easy-to-administer anti–SARS-CoV-2 treatments may be used to prevent progression from asymptomatic infection to symptomatic disease and to reduce viral carriage. OBJECTIVE: To evaluate the effect of combination subcutaneous casirivimab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1ecd30505beb30fbab21d922c4bc4bd
https://europepmc.org/articles/PMC8808333/
https://europepmc.org/articles/PMC8808333/
Autor:
Meagan P. O'Brien, Leah Lipsich, Samit Ganguly, Ajla Dupljak, George D. Yancopoulos, Ingeborg Heirman, David M. Weinreich, Cynthia Brinson, Eduardo Forleo-Neto, Gary Herman, Steven Folkerth, Jennifer D. Hamilton, Bari Kowal, Lori Faria, Gregory P. Geba, Jonathan Meyer, Kenneth C. Turner, Scott Rasmussen, Danielle Armas, Bret J Musser, Yuhwen Soo, Andrea T. Hooper, Masaru Oshita, Yunji Kim, Neena Sarkar, Flonza Isa, Wenjun Zheng, Adnan Mahmood, Ned Braunstein, Shikha Bansal
BackgroundData show that a single dose of casirivimab and imdevimab (REGEN-COV®) is effective in treating hospitalized individuals and outpatients with COVID-19 and in post-exposure prophylaxis. We present results from a phase 1, double-blind, place
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8bebb3369274283d5e1e4f7c352fbe6
https://doi.org/10.1101/2021.11.10.21265889
https://doi.org/10.1101/2021.11.10.21265889
Autor:
Roxanna Stoici, Ned Braunstein, David M. Weinreich, Cynthia Portal Celhay, Adil Fatakia, Janie Parrino, Bret J Musser, Eduardo Forleo-Neto, Christos A. Kyratsous, Leah Lipsich, John D. Davis, Adnan Mahmood, Bari Kowal, Yuhwen Soo, Gary Herman, Jennifer D. Hamilton, A. Thomas DiCioccio, Gregory P. Geba, Study Investigators, Neil Stahl, Cynthia Pan, Wendy Kampman, George D. Yancopoulos, Kenneth C. Turner, Thomas Norton, Andrea T. Hooper, Alina Baum, Yunji Kim, Will Eagan, Lilia Roque-Guerrero
SummaryBackgroundThe monoclonal antibody combination casirivimab and imdevimab (REGEN-COV®) reduced viral load, hospitalisation, or death when administered 1:1 as an intravenous (IV) dose ≥1200 mg in a phase 3 COVID-19 outpatient study. Availabili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b9a875a93281f66d52fbcaa787bee4b
https://doi.org/10.1101/2021.11.09.21265912
https://doi.org/10.1101/2021.11.09.21265912
Autor:
Wendy Kampman, Johnathan M. Lancaster, George D. Yancopoulos, George Betts, Ernesto Oviedo-Orta, David M. Weinreich, Ned Braunstein, Beth Holly, Margaret McDermott, Jennifer McGinniss, David Stein
BackgroundPatients with immunodeficiency-associated antibody disorders are at a higher risk of prolonged/persistent COVID-19 infection, having no viable treatment options.MethodsThis is a retrospective analysis of patients with primary and/or seconda
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::578dcade31110b2959d89d5a837a8ba1
https://doi.org/10.1101/2021.11.05.21265911
https://doi.org/10.1101/2021.11.05.21265911