Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Ned B. Smith"'
Autor:
Ashish P. Vartak, Peter A. Crooks, K. Grant Taylor, William M. Pierce, Ned B. Smith, Shama Nasim
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:7450-7453
A series of 3- O -phosphorylated analogs ( 4 – 10 ) of a novel bone-targeting estradiol analog ( 3 ) were synthesized after a thorough study of the reaction of 3 with a selection of phosphoryl chlorides under a variety of reaction conditions. Evalu
Autor:
Nicole K. Emery, Sujan Singh, Kevyn E. Merten, Leonard C. Waite, William M. Pierce, Ned B. Smith, K. Grant Taylor, Jian Cai, Natali B. Richter, Jason R. Neale
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:680-683
In this study a novel bone-targeting agent containing elements of the tricarbonylmethane system of ring A of tetracycline was developed and was shown to bind to the mineral constituent of bone, hydroxyapatite. Conjugation of this bone-targeting agent
Publikováno v:
Polycyclic Aromatic Compounds. 28:402-417
Xenobiotic-DNA adducts are used as biomarkers to assess the genotoxic effects of carcinogens. Rats were dosed with 4-aminobiphenyl (4-ABP), 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), or 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhI
Autor:
Randall Riggs, John O. Trent, Richard Bucala, Swen Zierow, Lin Leng, Millicent Winner, Jason B. Meier, Elias Lolis, Robert A. Mitchell, Beatriz E. Rendon, Gregg V. Crichlow, Ned B. Smith
Publikováno v:
Cancer Research. 68:7253-7257
Although chemokine and growth factor receptors are attractive and popular targets for cancer therapeutic intervention, structure-based targeting of the ligands themselves is generally not considered practical. New evidence indicates that a notable ex
Publikováno v:
Archives of Biochemistry and Biophysics. 389:278-287
Administration of dehydroepiandrosterone (DHEA) to rodents produces many unique biological responses, some of which may be due to metabolism of DHEA to more biologically active products. In the current study, DHEA metabolism was studied using human a
Autor:
William M. Pierce, Kristin J. Metry, Ned B. Smith, Jean Bendaly, David W. Hein, Jason R. Neale
2-Amino-3,8-dimethylimidazo-[4,5-f]quinoxaline (MeIQx) and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) are suspected human carcinogens generated in well done meats. After N-hydroxylation, they are O-acetylated by N-acetyltransferase 2 (NAT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07a064e956529fcdd939876ba45976f6
https://europepmc.org/articles/PMC2774981/
https://europepmc.org/articles/PMC2774981/
Autor:
Jean Bendaly, Jason R. Neale, William M. Pierce, J. C. States, G. Jiang, J. L. Holloman, Mark A. Doll, David W. Hein, Kristin J. Metry, Ned B. Smith
2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is carcinogenic in multiple organs and numerous species. Bioactivation of PhIP is initiated by PhIP N(2)-hydroxylation catalysed by cytochrome P450s. Following N-hydroxylation, O-acetylation cata
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63b233471d8eba5d6c491732a0d73c32
https://europepmc.org/articles/PMC2789189/
https://europepmc.org/articles/PMC2789189/
Autor:
Mark A. Doll, David W. Hein, Lori M. Millner, Ned B. Smith, Jean Bendaly, William M. Pierce, Kristin J. Metry
Publikováno v:
Mutation research. 671(1-2)
Aromatic amines such as 4-aminobiphenyl (ABP) require biotransformation to exert their carcinogenic effects. Genetic polymorphisms in biotransformation enzymes such as N-acetyltransferase 2 (NAT2) may modify cancer risk following exposure. Nucleotide
Autor:
Ned B. Smith, D. A. Davis, Mary Jayne Kennedy, Gregory L. Kearns, Andrea Gaedigk, Robin E. Pearce
Publikováno v:
Clinical pharmacology and therapeutics. 84(6)
Growth hormone (GH) regulates the sex-specific expression of drug-metabolizing enzymes (DMEs),1 and it has been shown that the clearance of multi-enzymatic substrates is altered following GH replacement.2,3 Baseline pharmacokinetic alterations have a
Autor:
Ned B. Smith, Gregory L. Kearns, Mary Jayne Kennedy, Andrea Gaedigk, Daniel A. Davis, Robin E. Pearce
Publikováno v:
Clinical therapeutics. 30(9)
Recombinant human growth hormone (r-hGH) is increasingly being used in children. Although growth hormone (GH) may alter the clearance of concomitantly administered medications, its effects on individual drug-metabolizing enzymes in children have not