Zobrazeno 1 - 10
of 430
pro vyhledávání: '"Ned A. Porter"'
Autor:
John Kim, Ian Spears, Clara Erice, Hye-Young H. Kim, Ned A. Porter, Caitlin Tressler, Elizabeth W. Tucker
Publikováno v:
Neurobiology of Disease, Vol 202, Iss , Pp 106721- (2024)
Tuberculous (TB) meningitis is the deadliest form of extrapulmonary TB which disproportionately affects children and immunocompromised individuals. Studies in pulmonary TB have shown that Mycobacterium tuberculosis can alter host lipid metabolism to
Externí odkaz:
https://doaj.org/article/ddedd996dfea47ca90a8bdd08de80f30
Autor:
Syed Masood, Hye-Young H. Kim, Edward R. Pennington, Keri A. Tallman, Ned A. Porter, Philip A. Bromberg, Rebecca L. Rice, Avram Gold, Zhenfa Zhang, James M. Samet
Publikováno v:
Redox Biology, Vol 73, Iss , Pp 103199- (2024)
Intracellular redox homeostasis in the airway epithelium is closely regulated through adaptive signaling and metabolic pathways. However, inhalational exposure to xenobiotic stressors such as secondary organic aerosols (SOA) can alter intracellular r
Externí odkaz:
https://doaj.org/article/b3f537d33a53496b96828ebccd9ff6cf
Autor:
Alexia N Perryman, Hye-Young H Kim, Alexis Payton, Julia E Rager, Erin E McNell, Meghan E Rebuli, Heather Wells, Martha Almond, Jamie Antinori, Neil E Alexis, Ned A Porter, Ilona Jaspers
Publikováno v:
PLoS ONE, Vol 18, Iss 5, p e0285721 (2023)
BackgroundOzone (O3) exposure causes respiratory effects including lung function decrements, increased lung permeability, and airway inflammation. Additionally, baseline metabolic state can predispose individuals to adverse health effects from O3. Fo
Externí odkaz:
https://doaj.org/article/937c884b7a9f4b45801f46e9b64b6441
Publikováno v:
Biomolecules, Vol 13, Iss 9, p 1321 (2023)
The concurrent use of several medications is a common practice in the treatment of complex psychiatric conditions. One such commonly used combination is aripiprazole (ARI), an antipsychotic, and trazodone (TRZ), an antidepressant. In addition to thei
Externí odkaz:
https://doaj.org/article/708e78d3b07c4f98ba77747e9078cad8
Autor:
Zeljka Korade, Luke B. Allen, Allison Anderson, Keri A. Tallman, Thiago C. Genaro-Mattos, Ned A. Porter, Karoly Mirnics
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Trazodone (TRZ) is a commonly prescribed antidepressant with significant off-label use for insomnia. A recent drug screening revealed that TRZ interferes with sterol biosynthesis, causing elevated levels of sterol precursor 7-dehydrocholeste
Externí odkaz:
https://doaj.org/article/67ed1de6baf7469e8270dfd73a93f59e
Autor:
Charlotte A. Love, Hye-Young H. Kim, Keri A. Tallman, Phillip W. Clapp, Ned A. Porter, Ilona Jaspers
Publikováno v:
Chemical Research in Toxicology. 36:565-569
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bbad08c1397cd4dcabcc2e0389215dcd
https://doi.org/10.1021/acs.chemrestox.3c00038
https://doi.org/10.1021/acs.chemrestox.3c00038
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 10, Pp 1916-1926 (2018)
Regulating blood cholesterol (Chol) levels by pharmacotherapy has successfully improved cardiovascular health. There is growing interest in the role of Chol precursors in the treatment of diseases. One sterol precursor, desmosterol (Des), is a potent
Externí odkaz:
https://doaj.org/article/50f5006f9d0b45b980c7fb46a72c0fbf
Autor:
Lucas S. Dantas, Adriano B. Chaves-Filho, Fernando R. Coelho, Thiago C. Genaro-Mattos, Keri A. Tallman, Ned A. Porter, Ohara Augusto, Sayuri Miyamoto
Publikováno v:
Redox Biology, Vol 19, Iss , Pp 105-115 (2018)
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by degeneration of upper and lower motor neurons. While the fundamental causes of the disease are still unclear, the accumulation of Cu,Zn-superoxide dismutase (SOD1) i
Externí odkaz:
https://doaj.org/article/eaaf64f788d74ebea9fb4310d3dfd13a
Autor:
Zeljka Korade, Keri A. Tallman, Hye-Young H. Kim, Marta Balog, Thiago C. Genaro-Mattos, Aryamav Pattnaik, Károly Mirnics, Asit K. Pattnaik, Ned A. Porter
Publikováno v:
ACS Pharmacology & Translational Science. 5:1086-1096
Cholesterol is ubiquitous in cells; it plays a critical role in membrane structure and transport as well as in intracellular trafficking processes. There are suggestions that cholesterol metabolism is linked to innate immunity with inhibitors of DHCR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ac21b2fc9bd865616ecf76470c3590f
https://doi.org/10.1021/acsptsci.2c00051
https://doi.org/10.1021/acsptsci.2c00051
Autor:
Katalin Koczok, László Horváth, Zeljka Korade, Zoltán András Mezei, Gabriella P. Szabó, Ned A. Porter, Eszter Kovács, Károly Mirnics, István Balogh
Publikováno v:
Biomolecules, Vol 11, Iss 8, p 1228 (2021)
Smith-Lemli-Opitz syndrome (SLOS) is a severe monogenic disorder resulting in low cholesterol and high 7-dehydrocholesterol (7-DHC) levels. 7-DHC-derived oxysterols likely contribute to disease pathophysiology, and thus antioxidant treatment might be
Externí odkaz:
https://doaj.org/article/e57d8c15226640629d33181f83162053