Zobrazeno 1 - 10
of 526
pro vyhledávání: '"Nectin-4"'
Autor:
Irene Testi, Giulia Claire Giudice, Giuseppe Salfi, Martino Pedrani, Sara Merler, Fabio Turco, Luigi Tortola, Ursula Vogl
Publikováno v:
Exploration of Targeted Anti-tumor Therapy, Vol 5, Iss 6, Pp 1326-1364 (2024)
Advanced urothelial carcinoma (aUC) has a dismal prognosis, with a 5-year survival rate of approximately 10%. Platinum-based chemotherapy has been the backbone of the first-line treatment of aUC for over 40 years. Only in the last decade, the treatme
Externí odkaz:
https://doaj.org/article/50345d19217b432891d671f63e69aa3f
Autor:
Cheng Wei, Xin Huang, Tianlong Xu, Yinan Fang, Fabao Wang, Qiaolin He, Peiyuan Zhang, Qianjin Yu, Ying Zhang, Binjiao Zheng, Yue Gao, Yongping Chen, Qichuan Zhuge, Ai Zhao, Jimin Gao, Jinhong Jiang
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionT cell Antigen Coupler (TAC) T cells harness all signaling subunits of endogenous T cell receptor (TCR) to trigger T-cell activation and tumor cell lysis, with minimal release of cytokines. Some of the major obstacles to cellular immunoth
Externí odkaz:
https://doaj.org/article/a60b92ced82045508b4898d4ffe2b58d
Autor:
Yue Wu, Min Zhu, Baihe Sun, Yongting Chen, Yuping Huang, Junwei Gai, Guanghui Li, Yanfei Li, Yakun Wan, Linlin Ma
Publikováno v:
Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-15 (2024)
Abstract Background Gastric cancer represents a highly lethal malignancy with an elevated mortality rate among cancer patients, coupled with a suboptimal postoperative survival prognosis. Nectin-4, an overexpressed oncological target for various canc
Externí odkaz:
https://doaj.org/article/71b584a9d087497584361c080b934efb
Autor:
Mariko Kotono, Toshiki Kijima, Atsuko Takada‐Owada, Naoya Okubo, Ryo Kurashina, Hidetoshi Kokubun, Toshitaka Uematsu, Kohei Takei, Kazuyuki Ishida, Takao Kamai
Publikováno v:
IJU Case Reports, Vol 7, Iss 2, Pp 173-176 (2024)
Introduction In addition to reduced nectin‐4 expression, the upregulation of ATP‐binding cassette transporters has been suggested as a potential mechanism of resistance to enfortumab vedotin. Case presentation A 76‐year‐old man previously tre
Externí odkaz:
https://doaj.org/article/63bcc92766b349b79fab938d17d6b54a
Akademický článek
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Autor:
Takamasa Homma, Kuniaki Tanaka, Naoya Takeda, Yu Okada, Shota Torii, Hideki Esaki, Takashi Sakakibara, Norio Takimoto
Publikováno v:
Case Reports in Oncology, Vol 16, Iss 1, Pp 1217-1222 (2023)
Enfortumab vedotin is an antibody-drug conjugate against nectin-4 that is recently being used in the management of patients with urothelial carcinoma. The common adverse events include rashes, peripheral neuropathy, and hyperglycemia. Only a few case
Externí odkaz:
https://doaj.org/article/2f1555a2f1604a6394b0ee9b59018b16
Akademický článek
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Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
Nectin-4 is a Ca2+-independent immunoglobulin-like protein that exhibits significantly elevated expression in malignant tumors while maintaining extremely low levels in healthy adult tissues. In recent years, overexpression of Nectin-4 has been impli
Externí odkaz:
https://doaj.org/article/15e29ffc7e324306bea3aa932b3a4084
Autor:
Ching-Hsuan Liu, Sy-Jye Leu, Chi-Hsin Lee, Cheng-Yuan Lin, Wei-Chu Wang, Bor-Yu Tsai, Yu-Ching Lee, Chi-Long Chen, Yi-Yuan Yang, Liang-Tzung Lin
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
BackgroundNectin-4 is a novel biomarker overexpressed in various types of cancer, including breast cancer, in which it has been associated with poor prognosis. Current literature suggests that nectin-4 has a role in cancer progression and may have pr
Externí odkaz:
https://doaj.org/article/3a0ab81d30994af48ae20487068b93e2
Akademický článek
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