Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Nectarios Klonis"'
Autor:
Con Dogovski, Stanley C Xie, Gaetan Burgio, Jess Bridgford, Sachel Mok, James M McCaw, Kesinee Chotivanich, Shannon Kenny, Nina Gnädig, Judith Straimer, Zbynek Bozdech, David A Fidock, Julie A Simpson, Arjen M Dondorp, Simon Foote, Nectarios Klonis, Leann Tilley
Publikováno v:
PLoS Biology, Vol 13, Iss 4, p e1002132 (2015)
Successful control of falciparum malaria depends greatly on treatment with artemisinin combination therapies. Thus, reports that resistance to artemisinins (ARTs) has emerged, and that the prevalence of this resistance is increasing, are alarming. AR
Externí odkaz:
https://doaj.org/article/b0443abb5c3b4803bfc017d66cf718e2
Autor:
Sébastien Boutet, Keith A. Nugent, Brian Abbey, Marc Messerschmidt, Leann Tilley, Harry M. Quiney, Con Dogovski, Ruben A. Dilanian, Victor A Streltsov, Andrew V. Martin, Sophie Williams, Garth J. Williams, Nicholas W. Phillips, Hannah D. Coughlan, Nectarios Klonis
Publikováno v:
Journal of Applied Crystallography
Serial femtosecond crystallography (SFX) at an X-ray free-electron laser enables crystllographic data to be collected from samples orders of magnitude smaller than at a synchrotron. Here SFX is used to investigate the nascent structure of β-hematin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cb3a5d100dcbd225deda28b68812bf4
https://ora.ox.ac.uk/objects/uuid:4898b9eb-53ff-43e3-98e8-6a51353161b7
https://ora.ox.ac.uk/objects/uuid:4898b9eb-53ff-43e3-98e8-6a51353161b7
Autor:
Stanley C. Xie, James M. McCaw, Leann Tilley, Nectarios Klonis, Tuo Yang, Darren J. Creek, Carlo Giannangelo, Pengxing Cao, Susan A. Charman
Publikováno v:
Antimicrobial Agents and Chemotherapy
Fully synthetic endoperoxide antimalarials, namely, OZ277 (RBx11160; also known as arterolane) and OZ439 (artefenomel), have been approved for marketing or are currently in clinical development. We undertook an analysis of the kinetics of the in vitr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84023fadbf345c78405404e2d763182b
https://doi.org/10.1128/aac.00574-16
https://doi.org/10.1128/aac.00574-16
Autor:
Leann Tilley, Oliver Looker, James M. Osborne, Megan K. Dearnley, Trang T. T. Chu, Yao Zhang, Mohit Arora, Rajesh Chandramohanadas, Matthew W. A. Dixon, Changjin Huang, Shannon Kenny, Sulin Zhang, Jeffrey A. Yeoman, Nectarios Klonis
Publikováno v:
Proceedings of the National Academy of Sciences. 113:4800-4805
The sexual blood stage of the human malaria parasite Plasmodium falciparum undergoes remarkable biophysical changes as it prepares for transmission to mosquitoes. During maturation, midstage gametocytes show low deformability and sequester in the bon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0af021221e440c546acfe44140e28266
https://doi.org/10.1073/pnas.1520194113
https://doi.org/10.1073/pnas.1520194113
Autor:
Eric Hanssen, Nectarios Klonis, María del Pilar Crespo, Silvia Teguh, Con Dogovski, Francis C. K. Chiu, Susan A. Charman, Steven Batinovic, Stanley C. Xie, Tuo Yang, Che A. Stafford, Leann Tilley
Publikováno v:
Journal of Cell Science
Current first-line artemisinin antimalarials are threatened by the emergence of resistant Plasmodium falciparum. Decreased sensitivity is evident in the initial (early ring) stage of intraerythrocytic development, meaning that it is crucial to unders
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f4a04d51660464987b58aee535afb2f
http://europepmc.org/articles/PMC4732288
http://europepmc.org/articles/PMC4732288
Autor:
Freya J. I. Fowkes, Sompob Saralamba, Pengxing Cao, Con Dogovski, Stanley C. Xie, Lisa J. White, Nectarios Klonis, James M. McCaw, Julie A. Simpson, Leann Tilley, Sophie Zaloumis
Publikováno v:
Antimicrobial Agents and Chemotherapy
Artemisinin resistance constitutes a major threat to the continued success of control programs for malaria. With alternative antimalarial drugs not yet available, improving our understanding of how artemisinin-based drugs act and how resistance manif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9568da4e9e6e1edbf40256f4bdce9cb
http://ora.ox.ac.uk/objects/uuid:
http://ora.ox.ac.uk/objects/uuid:
Autor:
Pengxing Cao, James M. McCaw, Julie A. Simpson, Sophie Zaloumis, Nectarios Klonis, Deborah Cromer, Miles P. Davenport, David S. Khoury, Leann Tilley
Falciparum malaria is a major parasitic disease causing widespread morbidity and mortality globally. Artemisinin derivatives---the most effective and widely-used antimalarials that have helped reduce the burden of malaria by 60% in some areas over th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f80e7ba695a1f266e11c22cc3946420
http://arxiv.org/abs/1701.05302
http://arxiv.org/abs/1701.05302
Publikováno v:
Current Opinion in Microbiology. 16:722-727
During the asexual blood stage of its lifecycle, the malaria parasite Plasmodium falciparum grows and multiplies in the hemoglobin-rich environment of the human erythrocyte. Although the parasite has evolved unique strategies to survive in this envir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::445160bbcce567abfb8ee484a31ce6ac
https://doi.org/10.1016/j.mib.2013.07.005
https://doi.org/10.1016/j.mib.2013.07.005
Autor:
Maria P. Crespo-Ortiz, Leann Tilley, Sophie Zaloumis, Stanley C. Xie, Julie A. Simpson, James M. McCaw, Nectarios Klonis
Publikováno v:
Proceedings of the National Academy of Sciences. 110:5157-5162
Reports of emerging resistance to first-line artemisinin antimalarials make it critical to define resistance mechanisms and identify in vitro correlates of resistance. Here we combine unique in vitro experimental and analytical approaches to mimic in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40ba6b076ded839d03b1e20b5c2b0135
https://doi.org/10.1073/pnas.1217452110
https://doi.org/10.1073/pnas.1217452110
Autor:
Philip J. Rosenthal, Iveta Bottova, Shannon Kenny, Nurhidanatasha Abu-Bakar, Nectarios Klonis, Maria P. Crespo-Ortiz, Leann Tilley
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Combination regimens that include artemisinin derivatives are recommended as first line antimalarials in most countries where malaria is endemic. However, the mechanism of action of artemisinin is not fully understood and the usefulness of this drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de7c878e3c54d6140b69f435d892aa03
https://doi.org/10.1073/pnas.1104063108
https://doi.org/10.1073/pnas.1104063108