Cyfip1 Regulates SynGAP1 at Hippocampal Synapses

Autor: Abhishek Sahasrabudhe, Fatema Begum, Christopher A. Guevara, Chenel Morrison, Kuangfu Hsiao, Nebojsa Kezunovic, Ozlem Bozdagi-Gunal, Deanna L. Benson

Publikováno v: Frontiers in Synaptic Neuroscience, Vol 12 (2021)

In humans, copy number variations in CYFIP1 appear to have sweeping physiological and structural consequences in the brain, either producing or altering the severity of intellectual disability, autism, and schizophrenia. Independently, SynGAP1 haploi

Externí odkaz: https://doaj.org/article/52856214e3974abc914af233826f7ebd

LRRK2 mutation alters behavioral, synaptic, and nonsynaptic adaptations to acute social stress

Autor: Bridget A. Matikainen-Ankney, Nebojsa Kezunovic, Caroline Menard, Deanna L. Benson, Christopher A. Guevara, Madeline L. Pfau, George W. Huntley, Alexander P. Conway, Meghan E. Flanigan, Katherine B. LeClair, Scott J. Russo

Publikováno v: J Neurophysiol

Parkinson’s disease (PD) risk is increased by stress and certain gene mutations, including the most prevalent PD-linked mutation LRRK2-G2019S. Both PD and stress increase risk for psychiatric symptoms, yet it is unclear how PD-risk genes alter neur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a0abf2b39104e1bff04caa0ad68822e
https://europepmc.org/articles/PMC7311730/

Presenilin1 familial Alzheimer disease mutants inactivate EFNB1- and BDNF-dependent neuroprotection against excitotoxicity by affecting neuroprotective complexes of N-methyl-d-aspartate receptor

Autor: Nebojsa Kezunovic, Zhiping Shao, Qian Huang, George W. Huntley, Christina Dimovasili, Lei Chen, Al Rahim, Yonejung Yoon, Adam Schaffner, Iban Ubarretxena-Belandia, Emily Zhang, Anastasios Georgakopoulos, Nikolaos K. Robakis

Publikováno v: Addi. Archivo Digital para la Docencia y la Investigación
instname
Addi: Archivo Digital para la Docencia y la Investigación
Universidad del País Vasco
Brain Communications

Excitotoxicity is thought to play key roles in brain neurodegeneration and stroke. Here we show that neuroprotection against excitotoxicity by trophic factors EFNB1 and brain-derived neurotrophic factor (called here factors) requires de novo formatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0519f2e942f41cd59f84dc2855a13b6b
http://hdl.handle.net/10810/51345

Modulation of gamma oscillations in the pedunculopontine nucleus by neuronal calcium sensor protein-1: relevance to schizophrenia and bipolar disorder

Autor: Stasia D'Onofrio, Edgar Garcia-Rill, James Hyde, Erick Messias, Nebojsa Kezunovic, Francisco J. Urbano, Brennon Luster

Publikováno v: Journal of Neurophysiology. 113:709-719

Reduced levels of gamma-band activity are present in schizophrenia and bipolar disorder patients. In the same disorders, increased neuronal calcium sensor protein-1 (NCS-1) expression was reported in a series of postmortem studies. These disorders ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c52c9635ec29d6674841efce56ed1ce3
https://doi.org/10.1152/jn.00828.2014

Gamma band activity in the RAS-intracellular mechanisms

Autor: Brennon Luster, Stasia D'Onofrio, Nebojsa Kezunovic, Francisco J. Urbano, Edgar Garcia-Rill, Veronica Bisagno, James Hyde

Publikováno v: Experimental Brain Research. 232:1509-1522

Gamma band activity participates in sensory perception, problem solving, and memory. This review considers recent evidence showing that cells in the reticular activating system (RAS) exhibit gamma band activity, and describes the intrinsic membrane p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21b1572cd52958fc946ce6b9888eea44
https://doi.org/10.1007/s00221-013-3794-8