Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Neblina Sikta"'
SARS‐CoV‐2 structural coverage map reveals viral protein assembly, mimicry, and hijacking mechanisms
Autor:
Seán I O’Donoghue, Andrea Schafferhans, Neblina Sikta, Christian Stolte, Sandeep Kaur, Bosco K Ho, Stuart Anderson, James B Procter, Christian Dallago, Nicola Bordin, Matt Adcock, Burkhard Rost
Publikováno v:
Molecular Systems Biology, Vol 17, Iss 9, Pp 1-24 (2021)
Abstract We modeled 3D structures of all SARS‐CoV‐2 proteins, generating 2,060 models that span 69% of the viral proteome and provide details not available elsewhere. We found that ˜6% of the proteome mimicked human proteins, while ˜7% was impl
Externí odkaz:
https://doaj.org/article/57f25c5fa4df43d2b612f9be089e03cc
Autor:
Fátima Valdés-Mora, Robert Salomon, Brian Stewart Gloss, Andrew Man Kit Law, Jeron Venhuizen, Lesley Castillo, Kendelle Joan Murphy, Astrid Magenau, Michael Papanicolaou, Laura Rodriguez de la Fuente, Daniel Lee Roden, Yolanda Colino-Sanguino, Zoya Kikhtyak, Nona Farbehi, James Ronald William Conway, Neblina Sikta, Samantha Richelle Oakes, Thomas Robert Cox, Seán Ignatius O’Donoghue, Paul Timpson, Christopher John Ormandy, David Gallego-Ortega
Publikováno v:
Cell Reports, Vol 35, Iss 2, Pp 108945- (2021)
Summary: Basal breast cancer is associated with younger age, early relapse, and a high mortality rate. Here, we use unbiased droplet-based single-cell RNA sequencing (RNA-seq) to elucidate the cellular basis of tumor progression during the specificat
Externí odkaz:
https://doaj.org/article/ea3e8ab5138c4f7d98816a22a8d74a0d
Autor:
Susannah T. Bellows, Jozef Gecz, Matthew Coleman, Thessa Kroes, Amy L Schneider, Brigid M. Regan, Karen Oliver, Samuel F. Berkovic, Haloom Rafehi, Douglas E. Crompton, Mark F. Bennett, Mark A. Corbett, Melanie Bahlo, Neblina Sikta, Michael S. Hildebrand, Ingrid E. Scheffer
Publikováno v:
Eur J Hum Genet
Familial adult myoclonic epilepsy 1 (FAME1), first recognised in Japanese families, was recently shown to be caused by a TTTCA repeat insertion in intron 4 of SAMD12 on chromosome 8. We performed whole genome sequencing on two families with FAME, one
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d946c8f449c4eae1478c4f9d4085b186
https://doi.org/10.1038/s41431-020-0606-z
https://doi.org/10.1038/s41431-020-0606-z
Autor:
David Thomas, Nicola Bordin, Mark J. Cowley, Seán I. O'Donoghue, Andrea Schafferhans, Mandy L. Ballinger, Sandeep Kaur, Neblina Sikta
MotivationVariant analysis is a core task in bioinformatics that requires integrating data from many sources. This process can be helped by using 3D structures of proteins, which can provide a spatial context that can provide insight into how variant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e6ad73d077f566bcccddc5f91c35674
https://doi.org/10.1101/2021.09.10.459756
https://doi.org/10.1101/2021.09.10.459756
SARS‐CoV‐2 structural coverage map reveals viral protein assembly, mimicry, and hijacking mechanisms
Autor:
James B. Procter, Sandeep Kaur, Christian Stolte, Seán I. O'Donoghue, Neblina Sikta, Matt Adcock, Bosco K. Ho, Christian Dallago, Burkhard Rost, Andrea Schafferhans, Stuart Anderson, Nicola Bordin
Publikováno v:
Molecular Systems Biology
Molecular Systems Biology, Vol 17, Iss 9, Pp n/a-n/a (2021)
Molecular Systems Biology, Vol 17, Iss 9, Pp n/a-n/a (2021)
We modeled 3D structures of all SARS‐CoV‐2 proteins, generating 2,060 models that span 69% of the viral proteome and provide details not available elsewhere. We found that ˜6% of the proteome mimicked human proteins, while ˜7% was implicated in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62144547588df9e95af66fa1b9c96d58
http://europepmc.org/articles/PMC8438690
http://europepmc.org/articles/PMC8438690
Autor:
Stuart Anderson, Sandeep Kaur, Christian Stolte, Andrea Schafferhans, James B. Procter, Neblina Sikta, Nicola Bordin, Matt Adcock, Burkhard Rost, Bosco K. Ho, Seán I. O'Donoghue, Christian Dallago
In response to the COVID-19 pandemic, many life scientists are focused on SARS-CoV-2. To help them use available structural data, we systematically modeled all viral proteins using all related 3D structures, generating 872 models that provide detail
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce7ec5a010584d2e408796b25291183b
https://doi.org/10.1101/2020.07.16.207308
https://doi.org/10.1101/2020.07.16.207308
Autor:
Neblina Sikta, Samantha R. Oakes, Lesley Castillo, Robert Salomon, Nona Farbehi, Fatima Valdes-Mora, Jeron Venhuizen, Thomas R. Cox, Andrew Man Kit Law, Laura Rodriguez de la Fuente, Kendelle J. Murphy, Michael Papanicolaou, Yolanda Colino-Sanguino, Brian S. Gloss, James R.W. Conway, Astrid Magenau, David Gallego-Ortega, Paul Timpson, Seán I. O'Donoghue, Zoya Kikhtyak, Daniel L. Roden, Christopher J. Ormandy
Publikováno v:
Cell Reports, 35
Cell Reports, 35, 2
Cell Reports, Vol 35, Iss 2, Pp 108945-(2021)
Cell Reports, 35, 2
Cell Reports, Vol 35, Iss 2, Pp 108945-(2021)
Contains fulltext : 240100.pdf (Publisher’s version ) (Open Access) Basal breast cancer is associated with younger age, early relapse, and a high mortality rate. Here, we use unbiased droplet-based single-cell RNA sequencing (RNA-seq) to elucidate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41db944850e8884f975a2af58026367d
https://doi.org/10.1016/j.celrep.2021.108945
https://doi.org/10.1016/j.celrep.2021.108945