Výsledky vyhledávání

Akademický článek

Potent carbonic anhydrase I, II, IX and XII inhibition activity of novel primary benzenesulfonamides incorporating bis-ureido moieties

Autor: Tuba Tekeli, Suleyman Akocak, Andrea Petreni, Nebih Lolak, Servet Çete, Claudiu T. Supuran

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)

A novel series of twelve aromatic bis-ureido-substituted benzenesulfonamides was synthesised by conjugation of aromatic aminobenzenesulfonamides with aromatic bis-isocyanates. The obtained bis-ureido-substituted derivatives were tested against four s

Externí odkaz: https://doaj.org/article/27d3d6164b084861b578bf702b6f3f3b

Zobrazit plný text záznamu

Plný text ve formátu HTML

Akademický článek

Synthesis of calix[4]azacrown substituted sulphonamides with antioxidant, acetylcholinesterase, butyrylcholinesterase, tyrosinase and carbonic anhydrase inhibitory action

Autor: Mehmet Oguz, Erbay Kalay, Suleyman Akocak, Alessio Nocentini, Nebih Lolak, Mehmet Boga, Mustafa Yilmaz, Claudiu T. Supuran

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1215-1223 (2020)

A series of novel calix[4]azacrown substituted sulphonamide Schiff bases was synthesised by the reaction of calix[4]azacrown aldehydes with different substituted primary and secondary sulphonamides. The obtained novel compounds were investigated as i

Externí odkaz: https://doaj.org/article/0f89ebb89dde45aea88d26dfdb740011

Zobrazit plný text záznamu

Plný text ve formátu HTML

Antibacterial and Antioxidant Activity Evaluation of Bis-Substituted İsovanillin Derivatives

Autor: Zehra TEKİN, Yener TEKELİ, Zehra KÜÇÜKBAY, Nebih LOLAK, Gönül YAPAR, Süleyman AKOCAK

Publikováno v: Journal of the Turkish Chemical Society Section A: Chemistry. :435-442

Herein, a series of twelve bis-hydrazone substituted isovanilline derivatives 3(a-l), were freshly re-synthesized by the reaction of bis-aldehydes with substituted hydrazide derivatives since these compounds previously showed potent aldose reductase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fe3f6a5ac47f29efb34ad0630b1ec4a6
https://doi.org/10.18596/jotcsa.1196335

Zobrazit plný text záznamu

Novel 1,3-diaryltriazene-substituted sulfaguanidine derivatives as selective carbonic anhydrase inhibitors: Synthesis, characterization, inhibition effects, and molecular docking studies

Autor: Suleyman Akocak, Nebih Lolak, Hatice Esra Duran, Mesut Işık, Cüneyt Türkeş, Mustafa Durgun, Şükrü Beydemir

Sulfonamide compounds known as human carbonic anhydrase (hCA) inhibitors are used in the treatment of many diseases such as epilepsy, antibacterial glaucoma, various diseases. 1,3-diaryl-substituted triazenes and sulfaguanidine are used for therapeut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0eebe77f75bad7fe5d08c1b026d857a0
https://doi.org/10.21203/rs.3.rs-2812331/v1

Zobrazit plný text záznamu

In Silico Studies and DNA Cleavage, Antioxidant, Acetylcholinesterase, and Butyrylcholinesterase Activity Evaluation of Bis-Histamine Schiff Bases and Bis-Spinaceamine Substituted Derivatives

Autor: Nebih Lolak, Mehmet Boga, Gorkem Deniz Sonmez, Muhammed Tuneg, Aslinur Dogan, Suleyman Akocak

Publikováno v: Pharmaceutical Chemistry Journal. 55:1338-1344

In this work, a series of seven bis-histamine Schiff bases (H1-H4) and bis-spinaceamine substituted derivatives (SPH1, SPH2, and SPH4) were successfully re-synthesized to evaluate their antioxidant properties by several bioanalytical methods such as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f616ed3522eee7f65f5d72d580182097
https://doi.org/10.1007/s11094-022-02581-7

Zobrazit plný text záznamu

Plný text ve formátu HTML

Novel bis-ureido-substituted sulfaguanidines and sulfisoxazoles as carbonic anhydrase and acetylcholinesterase inhibitors

Autor: Nebih Lolak, Süleyman Akocak, Mustafa Durgun, Hatice Esra Duran, Adem Necip, Cüneyt Türkeş, Mesut Işık, Şükrü Beydemir

Publikováno v: Molecular Diversity.

To discover alternative substances to compounds used to treat many diseases, especially treating Alzheimer's disease (AD) and Parkinson's disease targeting carbonic anhydrase (hCA) and acetylcholinesterase (AChE) enzymes, is important. For this purpo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bacb6195cfc61292ffb03b80d69e00d3
https://doi.org/10.1007/s11030-022-10527-0

Zobrazit plný text záznamu

Synthesis and biological evaluation of 1,3,5-triazine-substituted ureido benzenesulfonamides as antioxidant, acetylcholinesterase and butyrylcholinesterase inhibitors

Autor: Nebih Lolak, Muhammed Tuneğ, Aslınur Doğan, Mehmet Boğa, Suleyman Akocak

Publikováno v: Bioorganic and Medicinal Chemistry Reports. 3:22-31

A series of twenty 1,3,5-triazine-substituted ureido benzenesulfonamides 2 (a-e) and 3 (a-o) were re-synthesized and assayed for antioxidant properties by using several different methods including 1,1-diphenyl-2-picryl hydrazyl (DPPH) free radical sc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5c9cc02442369e1126b424a5110167c2
https://doi.org/10.25135/acg.bmcr.22.20.07.1706

Zobrazit plný text záznamu

Synthesis of calix[4]azacrown substituted sulphonamides with antioxidant, acetylcholinesterase, butyrylcholinesterase, tyrosinase and carbonic anhydrase inhibitory action

Autor: Erbay Kalay, Nebih Lolak, Suleyman Akocak, Mehmet Boga, Alessio Nocentini, Mustafa Yilmaz, Mehmet Oguz, Claudiu T. Supuran

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1215-1223 (2020)
Journal of Enzyme Inhibition and Medicinal Chemistry

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93bb147741e7f40954f448bb35b81ee0
https://doaj.org/article/0f89ebb89dde45aea88d26dfdb740011

Zobrazit plný text záznamu

Plný text ve formátu HTML

Vyhledávací nástroje:

Upřesnit hledání