Zobrazeno 1 - 10
of 397
pro vyhledávání: '"Neamine"'
Autor:
Jon Y. Takemoto, Guillermo A. Altenberg, Naveena Poudyal, Yagya P. Subedi, Cheng-Wei T. Chang
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
Widely-used Streptomyces-derived antibacterial aminoglycosides have encountered challenges because of antibiotic resistance and toxicity. Today, they are largely relegated to medicinal topical applications. However, chemical modification to amphiphil
Externí odkaz:
https://doaj.org/article/f849650328ed4a728f2130c5c872758b
Publikováno v:
ACS Omega, Vol 6, Iss 4, Pp 2824-2835 (2021)
Unambiguous assignments have been made for each individual pK a value of the amino group and guanidine substituents on 2-deoxystreptamine, neamine, neomycin, paromomycin, and streptomycin by pH-titration evaluation of their 1H, 13C, and 15N (by 1H-15
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee36ce28b11440789d1098f8f8ec8438
https://doaj.org/article/ea748c4a88254475b43996c9891aadba
https://doaj.org/article/ea748c4a88254475b43996c9891aadba
Autor:
Julie Kempf, Jitendriya Swain, Clément Dezanet, Hussein Chalhoub, Marie-Paule Mingeot-Leclercq, Marie Auquière, Jean-Luc Décout
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 8707, p 8707 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 16
International Journal of Molecular Sciences
Volume 22
Issue 16
Development of novel therapeutics to treat antibiotic-resistant infections, especially those caused by ESKAPE pathogens, is urgent. One of the most critical pathogens is P. aeruginosa, which is able to develop a large number of factors associated wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8b5c6836929f76e4a27c12abd4cb6b8
https://www.mdpi.com/1422-0067/22/16/8707
https://www.mdpi.com/1422-0067/22/16/8707
Autor:
Jitendriya Swain, Marie-Paule Mingeot-Leclercq, Patrick Van Der Smissen, Louis Zimmermann, Jean-Luc Décout, Micheline El Khoury, Guillaume Sautrey
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Scientific Reports, Vol. 7, no.1, p. 10697 (2017 [1-12])
Scientific Reports
Scientific Reports, Vol. 7, no.1, p. 10697 (2017 [1-12])
Scientific Reports
Some bacterial proteins involved in cell division and oxidative phosphorylation are tightly bound to cardiolipin. Cardiolipin is a non-bilayer anionic phospholipid found in bacterial inner membrane. It forms lipid microdomains located at the cell pol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf299447ad1bd8608fd138b356693f2c
http://link.springer.com/article/10.1038/s41598-017-10543-3
http://link.springer.com/article/10.1038/s41598-017-10543-3
Autor:
Estelle Dumont, Julia Vergalli, Rodolphe Alves de Sousa, Laure Maigre, Isabelle Artaud, Jean-Marie Pagès, Anas Allam
Publikováno v:
European Journal of Medicinal Chemistry. 127:748-756
Structure of bacterial envelope is one of the major factors contributing to Gram negative bacterial resistance. To develop new agents that target the bacterial membranes, we synthesized, by analogy with our previous peptide conjugates, new amphiphili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::955d6fcf2058b97f748033b0ef0cb3fc
https://doi.org/10.1016/j.ejmech.2016.10.054
https://doi.org/10.1016/j.ejmech.2016.10.054
Publikováno v:
Molecules
Volume 24
Issue 3
Molecules, Vol 24, Iss 3, p 580 (2019)
Volume 24
Issue 3
Molecules, Vol 24, Iss 3, p 580 (2019)
Glycosidic (&beta
1&prime
&prime
&rarr
6, 3&prime
and 4&prime
) site isomers of neomycin B (i.e., neobiosamine (&beta
) neamines) have been synthesized in a straightforward manner. Peracetylated neomycin azide was u
1&prime
&prime
&rarr
6, 3&prime
and 4&prime
) site isomers of neomycin B (i.e., neobiosamine (&beta
) neamines) have been synthesized in a straightforward manner. Peracetylated neomycin azide was u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81a7c4869ded3683768b5deb8cd5d1a0
Autor:
Patrick Van Der Smissen, Florian Briée, Jitendriya Swain, Jean-Luc Décout, Clément Dezanet, Aurélien Flament, Marie-Paule Mingeot-Leclercq, Micheline El Khoury
Publikováno v:
Biochimica et biophysica acta. Biomembranes, Vol. 861, no. 10, p. 182998 [1-10] (2019)
Amphiphilic aminoglycoside derivatives are potential new antimicrobial agents mostly developed to fight resistant bacteria. The mechanism of action of the 3',6-dinonyl neamine, one of the most promising derivative, has been investigated on Gram-negat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7d0504429ec291563e3f2a495c94cf5
https://hdl.handle.net/2078.1/216683
https://hdl.handle.net/2078.1/216683
Publikováno v:
The Journal of Antibiotics. 70:423-428
A radical S-adenosyl-l-methionine dehydratase AprD4 and an NADPH-dependent reductase AprD3 are responsible for the C3'-deoxygenation of pseudodisaccharide paromamine in the biosynthesis of apramycin. These enzymes are involved in the construction of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ccbb3bc6c33d4e5ebee420c8d06d69f
https://doi.org/10.1038/ja.2016.110
https://doi.org/10.1038/ja.2016.110
Autor:
Marta Kulik, Joanna Trylska
Publikováno v:
RAIRO - Operations Research. 50:375-386
Understanding the interactions which govern aminoglycoside antibiotic binding to ribosomal RNA is essential to propose modifications of these antibiotics. We have investigated the hydrogen bond patterns, solvent accessibility, and stacking energies o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76403b67ffbed0a496b1d0e1d053b31d
https://doi.org/10.1051/ro/2015041
https://doi.org/10.1051/ro/2015041
Publikováno v:
Journal of Huazhong University of Science and Technology [Medical Sciences]. 36:82-87
Neamine, a non-toxic derivative of neomycin, has recently been shown to have antitumor activities in various types of cancers. However, its effect on pancreatic cancer is still unknown. The study aimed to investigate its antitumor activity on pancrea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e6a7a2c914ce76f81f508c4eca3d73c
https://doi.org/10.1007/s11596-016-1546-2
https://doi.org/10.1007/s11596-016-1546-2