Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Nealia C.M. House"'
Publikováno v:
Frontiers in Genetics, Vol 5 (2014)
DNA repair must take place in the context of chromatin, and chromatin modifications and DNA repair are intimately linked. The study of double-strand break repair has revealed numerous histone modifications that occur after induction of a DSB, and mod
Externí odkaz:
https://doaj.org/article/bc6184f3bcf148eeb8e54f26b7e527d6
Autor:
Michael T. Hemann, Alexandria Van Scoyk, Jacob V. Layer, Alexander J. Brown, Tovah A. Day, Yunpeng Liu, Brendan D. Price, Steven A. Roberts, Kristen E. Stevenson, Nealia C.M. House, David M. Weinstock, Lydie Debaize
Publikováno v:
Proc Natl Acad Sci U S A
Recent studies have implicated DNA polymerases θ (Pol θ) and β (Pol β) as mediators of alternative nonhomologous end-joining (Alt-NHEJ) events, including chromosomal translocations. Here we identify subunits of the replicative DNA polymerase δ (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3003fff880d2d483ebaf9db588ff6cec
https://doi.org/10.1073/pnas.2014176117
https://doi.org/10.1073/pnas.2014176117
DNA repair requires reorganization of the local chromatin structure to facilitate access to and repair of the DNA. Studying DNA double-strand break (DSB) repair in specific chromatin domains has been aided by the use of sequence-specific endonuclease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::59a64ee3f125fe9d7140c016169f8f58
https://doi.org/10.1101/2020.08.04.235838
https://doi.org/10.1101/2020.08.04.235838
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0237759 (2020)
PLoS ONE
PLoS ONE
DNA repair requires reorganization of the local chromatin structure to facilitate access to and repair of the DNA. Studying DNA double-strand break (DSB) repair in specific chromatin domains has been aided by the use of sequence-specific endonuclease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64ba560c8ed46b1fbbacfbedd9243ea4
https://doaj.org/article/39bc6aaad662413c8546054ef5d6e3d8
https://doaj.org/article/39bc6aaad662413c8546054ef5d6e3d8
Autor:
Xiaofeng A Su, Robyn M Jong, Melissa R Koch, Nealia C.M. House, Cailin E. Joyce, Casey M. Cosetta, Christelle G Salomon, Elliot A Philips, Catherine H. Freudenreich
Publikováno v:
Genetics
CAG/CTG trinucleotide repeat expansions cause several degenerative neurological and muscular diseases. Koch et al. show that the chromatin remodeling...
CAG/CTG trinucleotide repeats are unstable sequences that are difficult to replicate, repair
CAG/CTG trinucleotide repeats are unstable sequences that are difficult to replicate, repair
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e95659d962c6eda6d258a6998ea838d
http://europepmc.org/articles/PMC5844344
http://europepmc.org/articles/PMC5844344
Publikováno v:
DNA Repair. 56:156-165
Eukaryotic genomes contain many repetitive DNA sequences that exhibit size instability. Some repeat elements have the added complication of being able to form secondary structures, such as hairpin loops, slipped DNA, triplex DNA or G-quadruplexes. Es
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ca8c006cd98d1afa41ae291709717cc
https://doi.org/10.1016/j.dnarep.2017.06.018
https://doi.org/10.1016/j.dnarep.2017.06.018
Autor:
Nealia C.M. House, Ishtiaque Quasem, Cailin E. Joyce, Stephen M. Fuchs, Marjorie De la Rosa Mejia, Catherine H. Freudenreich, Jocelyn E. Krebs, Oliver Takacsi-Nagy, Erica J Polleys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9acd2dc561cdc003bc7b572ba4ade450
https://doi.org/10.7554/elife.53362.sa2
https://doi.org/10.7554/elife.53362.sa2
Autor:
Simran Kaushal, Alice Haouzi, Catherine H. Freudenreich, Samantha B. Regan, Ryan P. Barnes, Soo Mi Lee, Suzanne E. Hile, Kohal Das, Kristin A. Eckert, Charles E. Wollmuth, Nealia C.M. House, Michael Guyumdzhyan
Publikováno v:
SSRN Electronic Journal.
Summary Common fragile sites (CFSs) are genomic regions that display gaps and breaks in human metaphase chromosomes under replication stress and are often deleted in cancer cells. We studied an ∼300-bp subregion (Flex1) of human CFS FRA16D in yeast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0330f6ddff209dbcc843e03f4f41435
https://doi.org/10.2139/ssrn.3335777
https://doi.org/10.2139/ssrn.3335777
Autor:
Ryan B. Hayman, Erica J Polleys, Stephen M. Fuchs, Nealia C.M. House, Catherine H. Freudenreich, Jocelyn E. Krebs, Oliver Takacsi-Nagy, Ishtiaque Quasem, Cailin E. Joyce
DNA are sites of genomic instability. Long CAG/CTG repeats form hairpin structures, are fragile, and can expand during DNA repair. The chromatin response to DNA damage can influence repair fidelity, but the knowledge of chromatin modifications involv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d396bd80c518bbb0d58daa64a82479a
https://doi.org/10.1101/331413
https://doi.org/10.1101/331413
Publikováno v:
Critical Reviews in Biochemistry and Molecular Biology. 50:142-167
The expansion of repeated sequences is the cause of over 30 inherited genetic diseases, including Huntington disease, myotonic dystrophy (types 1 and 2), fragile X syndrome, many spinocerebellar ataxias, and some cases of amyotrophic lateral sclerosi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02890fa99b663e5a36c3406291580aa6
https://doi.org/10.3109/10409238.2014.999192
https://doi.org/10.3109/10409238.2014.999192