Zobrazeno 1 - 10 of 140 pro vyhledávání: '"Neale D Ridgway"'
1
Akademický článek
Phosphorylation of a serine/proline-rich motif in oxysterol binding protein-related protein 4L (ORP4L) regulates cholesterol and vimentin binding.
Autor: Antonietta Pietrangelo, Neale D Ridgway
Publikováno v: PLoS ONE, Vol 14, Iss 3, p e0214768 (2019)
The family of oxysterol binding protein (OSBP) and OSBP-related proteins (ORPs) mediate sterol and phospholipid transfer and signaling at membrane contact sites (MCS). The activity of OSBP at MCS is regulated by phosphorylation, but whether this appl
Externí odkaz: https://doaj.org/article/178828d47b3a48739465d0b6f46640d7
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2
Akademický článek
Characterization of the sterol and phosphatidylinositol 4-phosphate binding properties of Golgi-associated OSBP-related protein 9 (ORP9).
Autor: Xinwei Liu, Neale D Ridgway
Publikováno v: PLoS ONE, Vol 9, Iss 9, p e108368 (2014)
Oxysterol binding protein (OSBP) and OSBP-related proteins (ORPS) have a conserved lipid-binding fold that accommodates cholesterol, oxysterols and/or phospholipids. The diversity of OSBP/ORPs and their potential ligands has complicated the analysis
Externí odkaz: https://doaj.org/article/1e6682c57d6c4ebe89428c4a7fac4340
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3
Akademický článek
Inhibition of HCV replication by oxysterol-binding protein-related protein 4 (ORP4) through interaction with HCV NS5B and alteration of lipid droplet formation.
Autor: In-Woo Park, Jean Ndjomou, Yahong Wen, Ziqing Liu, Neale D Ridgway, C Cheng Kao, Johnny J He
Publikováno v: PLoS ONE, Vol 8, Iss 9, p e75648 (2013)
Hepatitis C virus (HCV) RNA replication involves complex interactions among the 3'x RNA element within the HCV 3' untranslated region, viral and host proteins. However, many of the host proteins remain unknown. In this study, we devised an RNA affini
Externí odkaz: https://doaj.org/article/661500f6268c49ec932af85d73070c2a
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4
Akademický článek
Nuclear lipid droplets in Caco2 cells originate from nascent precursors and in situ at the nuclear envelope
Autor: Michael McPhee, Jonghwa Lee, Jayme Salsman, Marinella Pinelli, Francesca Di Cara, Kirill Rosen, Graham Dellaire, Neale D. Ridgway
Publikováno v: Journal of Lipid Research, Vol 65, Iss 5, Pp 100540- (2024)
Intestinal epithelial cells convert excess fatty acids into triglyceride (TAG) for storage in cytoplasmic lipid droplets and secretion in chylomicrons. Nuclear lipid droplets (nLDs) are present in intestinal cells but their origin and relationship to
Externí odkaz: https://doaj.org/article/7c3632dc14df4cafbcfc4d155a46f03c
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6
Differential dephosphorylation of CTP:phosphocholine cytidylyltransferase upon translocation to nuclear membranes and lipid droplets
Autor: Jonghwa Lee, Lambert Yue, Neale D. Ridgway, Michael McPhee, Rosemary B. Cornell, Steven L. Pelech, Jordan Thompson, Mark Charman, Dirk F. H. Winkler, Kevin Gonzalez
Publikováno v: Molecular Biology of the Cell
CTP:phosphocholine cytidylyltransferase-alpha (CCTα) and CCTβ catalyze the rate-limiting step in phosphatidylcholine (PC) biosynthesis. CCTα is activated by association of its α-helical M-domain with nuclear membranes, which is negatively regulat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bb471576d3b90d345d909a450ab9878
https://doi.org/10.1091/mbc.e20-01-0014
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9
Global Proximity Interactome of the Human Macroautophagy Pathway
Autor: Taoyingnan Li, Peter K. Kim, John H. Brumell, Julie D. Forman-Kay, Estelle M.N. Laurent, Rong Hua, Neale D. Ridgway, Andrew M. Sydor, Robert M. Vernon, Etienne Coyaud, Diana N Dyer, Nora Mellouk, Jonathan St-Germain, Brian Raught, Kexin Zhao, Yi Xin Iris Tu
Publikováno v: Autophagy
Autophagy, 2021, Autophagy, 18 (5), pp.1-13. ⟨10.1080/15548627.2021.1965711⟩
International audience; Macroautophagy is a highly conserved eukaryotic cellular pathway involving the engulfment of macromolecules, organelles, and invading microbes by a double-membrane compartment and subsequent lysosomal degradation. The mechanis
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e3e6ba281d072b2b819d5474782d72a
https://pubmed.ncbi.nlm.nih.gov/34524948
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10
Oxysterol-binding protein-related protein 1 variants have opposing cholesterol transport activities from the endolysosomes
Autor: Kexin Zhao, Neale D. Ridgway, Jason Foster
Publikováno v: Molecular Biology of the Cell
OSBPL1 encodes the full-length oxysterol-binding protein-related protein ORP1L, which transports LDL-derived cholesterol at membrane contacts between the late endosomes/lysosomes (LEL) and the endoplasmic reticulum (ER). OSBPL1 also encodes the trunc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61cf5c5fcb42c30ba7d778029b71fd84
http://europepmc.org/articles/PMC7185962
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