Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Neal Silverman"'
Autor:
Milton Pereira, Theresa Ramalho, Warrison A. Andrade, Danielle F. Durso, Maria C. Souza, Katherine A. Fitzgerald, Douglas T. Golenbock, Neal Silverman, Ricardo T. Gazzinelli
Publikováno v:
Cell Reports, Vol 43, Iss 2, Pp 113795- (2024)
Summary: Activation of endosomal Toll-like receptor (TLR) 7, TLR9, and TLR11/12 is a key event in the resistance against the parasite Toxoplasma gondii. Endosomal TLR engagement leads to expression of interleukin (IL)-12 via the myddosome, a protein
Externí odkaz:
https://doaj.org/article/d029504215a5498682a4f974d79d2f97
Autor:
Ravi Bharadwaj, Madison V. Anonick, Swati Jaiswal, Siavash Mashayekh, Ashley Brown, Kimberly A. Wodzanowski, Kendi Okuda, Neal Silverman, Catherine L. Grimes
Publikováno v:
Innate Immunity, Vol 29 (2023)
NOD1 and NOD2 sense small bacterial peptidoglycan fragments, often called muropeptides, that access the cytosol. These muropeptides include iE-DAP and MDP, the minimal agonists for NOD1 and NOD2, respectively. Here, we synthesized and validated alkyn
Externí odkaz:
https://doaj.org/article/5a0677d812094669ae240db66d274d24
Autor:
Kendi Okuda, Miriam Maria Silva Costa Franco, Ari Yasunaga, Ricardo Gazzinelli, Michel Rabinovitch, Sara Cherry, Neal Silverman
Publikováno v:
iScience, Vol 25, Iss 9, Pp 104909- (2022)
Summary: Leishmania parasites use elaborate virulence mechanisms to invade and thrive in macrophages. These virulence mechanisms inhibit host cell defense responses and generate a specialized replicative niche, the parasitophorous vacuole. In this wo
Externí odkaz:
https://doaj.org/article/74dea16b35d6401e94e8e63a85f665f2
Autor:
Deborah A Hogan, Joseph Heitman, Mary Ann Jabra-Rizk, Laura J Knoll, John M Leong, Neal Silverman
Publikováno v:
PLoS Pathogens, Vol 17, Iss 8, p e1009912 (2021)
Externí odkaz:
https://doaj.org/article/93955ba82e6a4c4bac9a6ce6f8de8792
Autor:
Tabassum Rahman, Abhinit Nagar, Ellen B. Duffy, Kendi Okuda, Neal Silverman, Jonathan A. Harton
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The NLRP3 inflammasome is central to host defense and implicated in various inflammatory diseases and conditions. While the favored paradigm of NLRP3 inflammasome activation stipulates a unifying signal intermediate that de-represses NLRP3, this view
Externí odkaz:
https://doaj.org/article/bf7762e5c0984479b3b447228e665b11
Autor:
Wenjing Zheng, Florentina Rus, Ana Hernandez, Ping Kang, William Goldman, Neal Silverman, Marc Tatar
Publikováno v:
BMC Biology, Vol 16, Iss 1, Pp 1-14 (2018)
Abstract Background Drosophila is a powerful model for the study of factors modulating innate immunity. This study examines the effect of water-loss dehydration on innate immune responsiveness in the Drosophila renal system (Malpighian tubules; MTs),
Externí odkaz:
https://doaj.org/article/5cba0ce38e224a86919bf3e649413050
Autor:
Anubhab Nandy, Lin Lin, Panagiotis D. Velentzas, Louisa P. Wu, Eric H. Baehrecke, Neal Silverman
Publikováno v:
Cell Reports, Vol 25, Iss 8, Pp 2110-2120.e3 (2018)
Summary: Macroautophagy and cell death both contribute to innate immunity, but little is known about how these processes integrate. Drosophila larval salivary glands require autophagy for developmentally programmed cell death, and innate immune signa
Externí odkaz:
https://doaj.org/article/0bea2c9364e94c909506906ec0df6901
Autor:
Monika Gulia-Nuss, Andrew B. Nuss, Jason M. Meyer, Daniel E. Sonenshine, R. Michael Roe, Robert M. Waterhouse, David B. Sattelle, José de la Fuente, Jose M. Ribeiro, Karine Megy, Jyothi Thimmapuram, Jason R. Miller, Brian P. Walenz, Sergey Koren, Jessica B. Hostetler, Mathangi Thiagarajan, Vinita S. Joardar, Linda I. Hannick, Shelby Bidwell, Martin P. Hammond, Sarah Young, Qiandong Zeng, Jenica L. Abrudan, Francisca C. Almeida, Nieves Ayllón, Ketaki Bhide, Brooke W. Bissinger, Elena Bonzon-Kulichenko, Steven D. Buckingham, Daniel R. Caffrey, Melissa J. Caimano, Vincent Croset, Timothy Driscoll, Don Gilbert, Joseph J. Gillespie, Gloria I. Giraldo-Calderón, Jeffrey M. Grabowski, David Jiang, Sayed M. S. Khalil, Donghun Kim, Katherine M. Kocan, Juraj Koči, Richard J. Kuhn, Timothy J. Kurtti, Kristin Lees, Emma G. Lang, Ryan C. Kennedy, Hyeogsun Kwon, Rushika Perera, Yumin Qi, Justin D. Radolf, Joyce M. Sakamoto, Alejandro Sánchez-Gracia, Maiara S. Severo, Neal Silverman, Ladislav Šimo, Marta Tojo, Cristian Tornador, Janice P. Van Zee, Jesús Vázquez, Filipe G. Vieira, Margarita Villar, Adam R. Wespiser, Yunlong Yang, Jiwei Zhu, Peter Arensburger, Patricia V. Pietrantonio, Stephen C. Barker, Renfu Shao, Evgeny M. Zdobnov, Frank Hauser, Cornelis J. P. Grimmelikhuijzen, Yoonseong Park, Julio Rozas, Richard Benton, Joao H. F. Pedra, David R. Nelson, Maria F. Unger, Jose M. C. Tubio, Zhijian Tu, Hugh M. Robertson, Martin Shumway, Granger Sutton, Jennifer R. Wortman, Daniel Lawson, Stephen K. Wikel, Vishvanath M. Nene, Claire M. Fraser, Frank H. Collins, Bruce Birren, Karen E. Nelson, Elisabet Caler, Catherine A. Hill
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Ticks transmit a large number of pathogens that cause human diseases. Here, the authors sequence the genome of the tick Ixodes scapularisand uncover expansion of genes associated with parasitic processes unique to ticks and tick-host interactions.
Externí odkaz:
https://doaj.org/article/fa4043b3779c4d0db50b094e385f7e3b
p38b and JAK-STAT signaling protect against Invertebrate iridescent virus 6 infection in Drosophila.
Autor:
Cara West, Neal Silverman
Publikováno v:
PLoS Pathogens, Vol 14, Iss 5, p e1007020 (2018)
The fruit fly Drosophila melanogaster is a powerful model system for the study of innate immunity in vector insects as well as mammals. For vector insects, it is particularly important to understand all aspects of their antiviral immune defenses, whi
Externí odkaz:
https://doaj.org/article/d47ec0cf98374127a24d5e707b16d24a
Autor:
Kendi Okuda, Neal Silverman
Publikováno v:
Bio-Protocol, Vol 7, Iss 23 (2017)
This protocol describes how to generate and harvest antibody-free L. amazonensis amastigotes, and how to infect adult Drosophila melanogaster with these parasites. This model recapitulates key aspects of the interactions between Leishmania amastigote
Externí odkaz:
https://doaj.org/article/17f5852d0ae1439aaa651ca908f4944c