Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Neal Sach"'
Autor:
Rebecca A. Gallego, Louise Bernier, Hui Chen, Sujin Cho-Schultz, Loanne Chung, Michael Collins, Matthew Del Bel, Jeff Elleraas, Cinthia Costa Jones, Ciaran N. Cronin, Martin Edwards, Xu Fang, Timothy Fisher, Mingying He, Jacqui Hoffman, Ruiduan Huo, Mehran Jalaie, Eric Johnson, Ted W. Johnson, Robert S. Kania, Manfred Kraus, Jennifer Lafontaine, Phuong Le, Tongnan Liu, Michael Maestre, Jean Matthews, Michele McTigue, Nichol Miller, Qiming Mu, Xulong Qin, Shijian Ren, Paul Richardson, Allison Rohner, Neal Sach, Li Shao, Graham Smith, Ruirui Su, Bin Sun, Sergei Timofeevski, Phuong Tran, Shuiwang Wang, Wei Wang, Ru Zhou, Jinjiang Zhu, Sajiv K. Nair
Publikováno v:
Journal of Medicinal Chemistry. 66:4888-4909
Autor:
Emma King-Smith, Simon Berritt, Louise Bernier, Xinjun Hou, Jacquelyn Klug-McLeod, Jason Mustakis, Neal Sach, Joseph Tucker, Qingyi Yang, Roger Howard, Alpha Lee
High-throughput experimentation (HTE) has the potential to improve our understanding of organic chemistry by systematically interrogating reactivity across diverse chemical spaces. Notable bottlenecks include few publicly available large-scale datase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fe10aa2abc0085ed30e2d72972a8424
https://doi.org/10.21203/rs.3.rs-2262919/v1
https://doi.org/10.21203/rs.3.rs-2262919/v1
Autor:
Hui‐Qi Ni, Phillippa Cooper, Shouliang Yang, Fen Wang, Neal Sach, Pranali G. Bedekar, Joyann S. Donaldson, Michelle Tran‐Dubé, Indrawan J. McAlpine, Keary M. Engle
Publikováno v:
Angewandte Chemie. 134
Autor:
Hui-Qi, Ni, Phillippa, Cooper, Shouliang, Yang, Fen, Wang, Neal, Sach, Pranali G, Bedekar, Joyann S, Donaldson, Michelle, Tran-Dubé, Indrawan J, McAlpine, Keary M, Engle
Publikováno v:
Angew Chem Int Ed Engl
In this study, we systematically evaluate different ambiphilic organohalides for their ability to participate in anti-selective carbo- or heteroannulation with non-conjugated alkenyl amides under Pd catalysis. Detailed optimization of reaction condit
Autor:
Manjinder S, Lall, Asser, Bassyouni, James, Bradow, Maria, Brown, Mark, Bundesmann, Jinshan, Chen, Gregory, Ciszewski, Anne E, Hagen, Dennis, Hyek, Stephen, Jenkinson, Bo, Liu, R Scott, Obach, Senliang, Pan, Usa, Reilly, Neal, Sach, Daniel J, Smaltz, Douglas K, Spracklin, Jeremy, Starr, Melissa, Wagenaar, Gregory S, Walker
Publikováno v:
Journal of medicinal chemistry. 63(13)
An experimental approach is described for late-stage lead diversification of frontrunner drug candidates using nanomole-scale amounts of lead compounds for structure-activity relationship development. The process utilizes C-H bond activation methods
Autor:
Pei-Pei, Kung, Patrick, Bingham, Alexei, Brooun, Michael, Collins, Ya-Li, Deng, Dac, Dinh, Connie, Fan, Ketan S, Gajiwala, Rita, Grantner, Hovhannes J, Gukasyan, Wenyue, Hu, Buwen, Huang, Robert, Kania, Susan E, Kephart, Cody, Krivacic, Robert A, Kumpf, Penney, Khamphavong, Manfred, Kraus, Wei, Liu, Karen A, Maegley, Lisa, Nguyen, Shijian, Ren, Dan, Richter, Robert A, Rollins, Neal, Sach, Shikhar, Sharma, John, Sherrill, Jillian, Spangler, Albert E, Stewart, Scott, Sutton, Sean, Uryu, Dominique, Verhelle, Hui, Wang, Shuiwang, Wang, Martin, Wythes, Shuibo, Xin, Shinji, Yamazaki, Huichun, Zhu, JinJiang, Zhu, Luke, Zehnder, Martin, Edwards
Publikováno v:
Journal of medicinal chemistry. 61(3)
A new series of lactam-derived EZH2 inhibitors was designed via ligand-based and physicochemical-property-based strategies to address metabolic stability and thermodynamic solubility issues associated with previous lead compound 1. The new inhibitors
Autor:
Thomas, Knauber, Ramalakshmi, Chandrasekaran, Joseph W, Tucker, Jinshan Michael, Chen, Matthew, Reese, Danica A, Rankic, Neal, Sach, Christopher, Helal
Publikováno v:
Organic letters. 19(24)
A mild Ru/Ni dual catalytic desulfinative photoredox C
Autor:
Hengmiao, Cheng, Sajiv K, Nair, Brion W, Murray, Chau, Almaden, Simon, Bailey, Sangita, Baxi, Doug, Behenna, Sujin, Cho-Schultz, Deepak, Dalvie, Dac M, Dinh, Martin P, Edwards, Jun Li, Feng, Rose Ann, Ferre, Ketan S, Gajiwala, Michelle D, Hemkens, Amy, Jackson-Fisher, Mehran, Jalaie, Ted O, Johnson, Robert S, Kania, Susan, Kephart, Jennifer, Lafontaine, Beth, Lunney, Kevin K-C, Liu, Zhengyu, Liu, Jean, Matthews, Asako, Nagata, Sherry, Niessen, Martha A, Ornelas, Suvi T M, Orr, Mason, Pairish, Simon, Planken, Shijian, Ren, Daniel, Richter, Kevin, Ryan, Neal, Sach, Hong, Shen, Tod, Smeal, Jim, Solowiej, Scott, Sutton, Khanh, Tran, Elaine, Tseng, William, Vernier, Marlena, Walls, Shuiwang, Wang, Scott L, Weinrich, Shuibo, Xin, Haiwei, Xu, Min-Jean, Yin, Michael, Zientek, Ru, Zhou, John C, Kath
Publikováno v:
Journal of medicinal chemistry. 59(5)
First generation EGFR TKIs (gefitinib, erlotinib) provide significant clinical benefit for NSCLC cancer patients with oncogenic EGFR mutations. Ultimately, these patients' disease progresses, often driven by a second-site mutation in the EGFR kinase