Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Neal S. Silverman"'
Autor:
Ari Yasunaga, Sara Cherry, Kendi Okuda, Ricardo T. Gazzinelli, Neal S. Silverman, Miriam Maria Silva Costa Franco, Michel Rabinovitch
Publikováno v:
SSRN Electronic Journal.
Leishmania parasites use elaborate virulence mechanisms to invade and thrive in macrophages. These virulence mechanisms inhibit host cell defense responses and generate a specialized replicative niche, the parasitophorous vacuole. In this work, we pe
Autor:
Cara C. West, Neal S. Silverman
Publikováno v:
Nature. 597:34-35
Aspects of how immune defence processes evolved remain mysterious. Studies of the fly Drosophila melanogaster reveal previously unknown details of a defence pathway with echoes of, but key differences from, a human pathway. cGas-like receptors aid im
Autor:
Abhinit Nagar, Tabassum Rahman, Jonathan A. Harton, Ellen B. Duffy, Kendi Okuda, Neal S. Silverman
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Frontiers in Immunology
Frontiers in Immunology
The NLRP3 inflammasome is central to host defense and implicated in various inflammatory diseases and conditions. While the favored paradigm of NLRP3 inflammasome activation stipulates a unifying signal intermediate that de-represses NLRP3, this view
Autor:
John M. Leong, Neal S. Silverman, Joseph Heitman, Laura J. Knoll, Mary Ann Jabra-Rizk, Deborah A. Hogan
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 8, p e1009912 (2021)
PLoS Pathogens, Vol 17, Iss 8, p e1009912 (2021)
The human microbiome constitutes the collection of all the microorganisms living in association with the human body with each body site being home to a unique microbial community [1]. Human-associated microbial communities can include eukaryotes, arc
SLC46 Family Transporters Facilitate Cytosolic Innate Immune Recognition of Monomeric Peptidoglycans
Autor:
Amanda J. Monahan, Donggi Paik, Roland Elling, William E. Goldman, Daniel R. Caffrey, Neal S. Silverman
Publikováno v:
The Journal of Immunology. 199:263-270
Tracheal cytotoxin (TCT), a monomer of DAP-type peptidoglycan from Bordetella pertussis, causes cytopathology in the respiratory epithelia of mammals and robustly triggers the Drosophila Imd pathway. PGRP-LE, a cytosolic innate immune sensor in Droso
Publikováno v:
Current biology : CB, vol 27, iss 6
The recent discovery of the positive-sense single-stranded RNA (ssRNA) Orsay virus (OV) as a natural pathogen of the nematode Caenorhabditis elegans has stimulated interest in exploring virus-nematode interactions. However, OV infection is restricted
Autor:
Florentina Rus, Cara C. West, Anni Kleino, Ying Chen, Don B. Gammon, Monique Gangloff, Neal S. Silverman
Publikováno v:
Viruses, Vol 11, Iss 5, p 409 (2019)
Viruses
Volume 11
Issue 5
Kleino, A P, West, C, Rus, F, Gangloff, M, Gammon, D, Silverman, N & Chen, Y 2019, ' IIV-6 Inhibits NF-κB Responses in Drosophila ' Viruses . https://doi.org/10.3390/v11050409
Viruses
Volume 11
Issue 5
Kleino, A P, West, C, Rus, F, Gangloff, M, Gammon, D, Silverman, N & Chen, Y 2019, ' IIV-6 Inhibits NF-κB Responses in Drosophila ' Viruses . https://doi.org/10.3390/v11050409
The host immune response and virus-encoded immune evasion proteins pose constant, mutual selective pressure on each other. Virally encoded immune evasion proteins also indicate which host pathways must be inhibited to allow for viral replication. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81719fe2be85626d947a2409917ed227
https://www.repository.cam.ac.uk/handle/1810/292410
https://www.repository.cam.ac.uk/handle/1810/292410
Autor:
Chris Sherlock, Ermelinda Porpiglia, Florentina Rus, Subba Reddy Palli, Rochele Yamamoto, Andreas Heyland, Alina Garbuzov, Neal S. Silverman, Marc Tatar, Thomas Flatt
Publikováno v:
Flatt, T, Heyland, A, Rus, F, Porpiglia, E, Sherlock, C, Yamamoto, R, Garbuzov, A, Palli, S R, Tatar, M & Silverman, N 2008, ' Hormonal regulation of the humoral innate immune response in Drosophila melanogaster ', The Journal of Experimental Biology, vol. 211, no. Pt 16, pp. 2712-24 . https://doi.org/10.1242/jeb.014878
SUMMARYJuvenile hormone (JH) and 20-hydroxy-ecdysone (20E) are highly versatile hormones, coordinating development, growth, reproduction and aging in insects. Pulses of 20E provide key signals for initiating developmental and physiological transition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58043fe0f6d848020d4440e4097746df
http://doc.rero.ch/record/324338/files/2008_hth.pdf
http://doc.rero.ch/record/324338/files/2008_hth.pdf
Autor:
Anni Kleino, Neal S. Silverman
Publikováno v:
Kleino, A P & Silverman, N 2019, ' Regulation of the Drosophila Imd pathway by signaling amyloids ', Insect Biochemistry and Molecular Biology, vol. 108, no. May, pp. 16-23 . https://doi.org/10.1016/j.ibmb.2019.03.003
Insect Biochem Mol Biol
Insect Biochem Mol Biol
Fruit flies elicit effective defense responses against numerous microbes. The responses against Gram-negative bacteria are mediated by the Imd pathway, an evolutionarily conserved NF-κB pathway recognizing meso-diaminopimelic acid (DAP)-type peptido
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35482b5316206213549de3299d455a7b
https://pure.au.dk/portal/da/publications/regulation-of-the-drosophila-imd-pathway-by-signaling-amyloids(1f4d7e06-eb20-45b5-8aaa-88cac9d34360).html
https://pure.au.dk/portal/da/publications/regulation-of-the-drosophila-imd-pathway-by-signaling-amyloids(1f4d7e06-eb20-45b5-8aaa-88cac9d34360).html
Autor:
Man Shi, Xiaoman Zhang, Daniel L. Kastner, Ellen M. Gravallese, Charles V. Rosadini, Murali K. Akula, Kira Gritsman, Donghai Wang, Susan Carpenter, Katherine A. Fitzgerald, Zhaozhao Jiang, Annie S Li, Randolph Y. Hampton, David Miao, Jonathan C. Kagan, Ruth M Gavin, Celia E Foster, Douglas T. Golenbock, Martin O. Bergo, Sorcha D. Forde, Jae Jin Chae, Neal S. Silverman, Gail Germain
Publikováno v:
Nature immunology
Nature immunology, vol 17, iss 8
Nature immunology, vol 17, iss 8
Deficiency in mevalonate kinase (MVK) causes systemic inflammation. However, the molecular mechanisms linking the mevalonate pathway to inflammation remain obscure. Geranylgeranyl pyrophosphate, a non-sterol intermediate of the mevalonate pathway, is