Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Neal S. Schilling"'
Autor:
Neal S. Schilling, Anthony J. Capobianco, Stephane Houel, William M. Old, Samer Singh, Natalie G. Ahn, Jun Long, Robert Tokhunts, Jezabel Rodgriguez-Blanco, David J. Robbins
Publikováno v:
Cell Reports, Vol 10, Iss 8, Pp 1280-1287 (2015)
SummaryHedgehog (HH) proteins are proteolytically processed into a biologically active form that is covalently modified by cholesterol and palmitate. However, most studies of HH biogenesis have characterized protein from cells in which HH is overexpr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a757ec48cb2eb0bb1f103089fa8e086
http://www.sciencedirect.com/science/article/pii/S221112471500100X
http://www.sciencedirect.com/science/article/pii/S221112471500100X
Autor:
Chang Xiao, Sally A. Ogle, David J. Robbins, Yana Zavros, Michael A. Schumacher, Robert Tokhunts, Frédéric Hollande, Neal S. Schilling, Melissa A. Orr-Asman, Marian L. Miller
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 299:G1252-G1265
In the stomach, strictly regulated cell adherens junctions are crucial in determining epithelial cell differentiation. Sonic Hedgehog (Shh) regulates epithelial cell differentiation in the adult stomach. We sought to identify whether Shh plays a role
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::209f16ee37436c655fbf6fdf6f356194
https://doi.org/10.1152/ajpgi.00512.2009
https://doi.org/10.1152/ajpgi.00512.2009
Autor:
David J. Robbins, Neal S. Schilling, Todd A. MacKenzie, John A. Goetz, Kendall E. Black, Samer Singh, Zhen Jane Huang, Nadia Dahmane, Valerie Baubet, Robert Tokhunts
Publikováno v:
Human Genetics. 125:95-103
Sonic Hedgehog (SHH) plays an important instructional role in vertebrate development, as exemplified by the numerous developmental disorders that occur when the SHH pathway is disrupted. Mutations in the SHH gene are the most common cause of sporadic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de642f2ed81972a41881f1968eab13e1
https://doi.org/10.1007/s00439-008-0599-0
https://doi.org/10.1007/s00439-008-0599-0
Autor:
Stacey K. Ogden, John Hwa, David J. Robbins, Dennis Liang Fei, Yashi Ahmed, Neal S. Schilling
Publikováno v:
Nature
Whether G proteins might play a role in Hedgehog (Hh) signal transduction has been controversial. Here, the seven-domain transmembrane protein Smoothened (Smo) is shown to activate a G protein, Gαi, to modulate intracellular cyclic AMP levels in res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fefbbf9db4fdff5c3a661fb46c5262c7
https://doi.org/10.1038/nature07459
https://doi.org/10.1038/nature07459
Autor:
William W. Lockwood, David J. Robbins, Marilyn K. Glassberg, S. Elliot, Zhiqiang Wang, Robert Tokhunts, Fabrizio Galimberti, Jun Long, Dao M. Nguyen, Camilla Giambelli, Ethan Dmitrovsky, Pablo A. Bejarano, Neal S. Schilling, Samer Singh, Jezabel Rodriguez-Blanco, D. Liang Fei, Wan L. Lam, Kendall E. Black, Anthony J. Capobianco
Considerable interest has been generated from the results of recent clinical trials using SMOOTHENED (SMO) antagonists to inhibit the growth of HEDGEHOG (HH) signaling dependent tumors. This interest is tempered by the discovery of SMO mutations medi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ced15716e971c670362f33a017aa3480
https://europepmc.org/articles/PMC3821972/
https://europepmc.org/articles/PMC3821972/
Publikováno v:
American journal of physiology. Gastrointestinal and liver physiology. 294(4)
The Hedgehog (Hh) family of secreted proteins is necessary for aspects of the development and maintenance of the gastrointestinal tract. Hh is thought to function as a morphogen, a mitogen, a cell survival factor, and an axon guidance factor. Given i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2a2dfb5113a30487f1e0620025500ed
https://pubmed.ncbi.nlm.nih.gov/18239057
https://pubmed.ncbi.nlm.nih.gov/18239057