Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Neal S. Gould"'
Autor:
Scott Ugras, Malcolm J. Daniels, Hossein Fazelinia, Neal S. Gould, Anastasia K. Yocum, Kelvin C. Luk, Esteban Luna, Hua Ding, Chris McKennan, Steven Seeholzer, Dan Martinez, Perry Evans, Daniel Brown, John E. Duda, Harry Ischiropoulos
Publikováno v:
EBioMedicine, Vol 31, Iss , Pp 307-319 (2018)
Accumulation of aggregated α-synuclein into Lewy bodies is thought to contribute to the onset and progression of dopaminergic neuron degeneration in Parkinson's disease (PD) and related disorders. Although protein aggregation is associated with pert
Externí odkaz:
https://doaj.org/article/1a369182b6fc429891ec416beb23e350
Autor:
Daniel Martinez, Malcolm J. Daniels, Harry Ischiropoulos, Perry Evans, Hua Ding, Steven H. Seeholzer, Hossein Fazelinia, Scott E. Ugras, Kelvin C. Luk, Daniel P. Brown, John E. Duda, Esteban Luna, Neal S. Gould, Anastasia K. Yocum, Chris McKennan
Publikováno v:
EBioMedicine, Vol 31, Iss, Pp 307-319 (2018)
EBioMedicine
EBioMedicine
Accumulation of aggregated α-synuclein into Lewy bodies is thought to contribute to the onset and progression of dopaminergic neuron degeneration in Parkinson's disease (PD) and related disorders. Although protein aggregation is associated with pert
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e85f997560715e85a4ca349b9c721b3
http://www.sciencedirect.com/science/article/pii/S2352396418301622
http://www.sciencedirect.com/science/article/pii/S2352396418301622
Autor:
John H. Wolfe, Joseph R. Mazzulli, Kim A. Caldwell, Elpida Tsika, Guy A. Caldwell, Hanna Kim, Malcolm J. Daniels, Neal S. Gould, Harry Ischiropoulos, Shachee Doshi, Victor X Tan, Robert G. Kalb, Jennifer L Grossman, Danielle Emille Mor, Preetika Gupta
Publikováno v:
Nature neuroscience
Parkinson's disease (PD) is defined by the loss of dopaminergic neurons in the substantia nigra and the formation of Lewy body inclusions containing aggregated α-synuclein. Efforts to explain dopamine neuron vulnerability are hindered by the lack of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4a943f517d82867ef033b4baf3d0c31
https://doi.org/10.1038/nn.4641
https://doi.org/10.1038/nn.4641
Autor:
Neal S, Gould
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1967
The wide reactivity of the thiol group enables the formation of a number of chemically and biologically distinct posttranslational modifications. Proteins within nearly all major families undergo some form of cysteine modification and the modificatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::355832eff34dc293803ec89198c10afb
https://pubmed.ncbi.nlm.nih.gov/31069771
https://pubmed.ncbi.nlm.nih.gov/31069771
Autor:
Isabella C. Felli, Hanna Kim, Elizabeth Rhoades, John J. Ferrie, Valerio Sainati, Neal S. Gould, Kim A. Caldwell, Vladimir N. Uversky, Conor M. Haney, Rita Grandori, Harry Ischiropoulos, Buyan Pan, Roberta Pierattelli, Marco Schiavina, Guy A. Caldwell, Malcolm J. Daniels, E. James Petersson, Rani Moons, Ed S. Krol, Maria Grazia Murrali, J. Brucker Nourse, Antonino Natalello, Frank Sobott
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-17 (2019)
Scientific reports
Scientific Reports, Vol 9, Iss 1, Pp 1-17 (2019)
Scientific reports
Growing evidence implicates α-synuclein aggregation as a key driver of neurodegeneration in Parkinson’s disease (PD) and other neurodegenerative disorders. Herein, the molecular and structural mechanisms of inhibiting α-synuclein aggregation by n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2d72bab720b8bb353b4875ab877a36f
http://europepmc.org/articles/PMC6393491
http://europepmc.org/articles/PMC6393491
Autor:
Neal S. Gould
Publikováno v:
Methods in Molecular Biology ISBN: 9781493991860
The wide reactivity of the thiol group enables the formation of a number of chemically and biologically distinct posttranslational modifications. Proteins within nearly all major families undergo some form of cysteine modification and the modificatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a02241be4823387823d2665b9847275
https://doi.org/10.1007/978-1-4939-9187-7_11
https://doi.org/10.1007/978-1-4939-9187-7_11
Publikováno v:
Current Protocols in Protein Science. 94
The wide reactivity of the thiol group enables the formation of a variety of reversible, covalent modifications on cysteine residues. S-nitrosylation, like many other post-translational modifications, is site selective, reversible, and necessary for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6299240f69aa191f0830737e7973fcf
https://doi.org/10.1002/cpps.69
https://doi.org/10.1002/cpps.69
Autor:
Neal S. Gould, Brian J. Day, Richard J. Martin, Hong Wei Chu, Elysia Min, James T. Good, Jie Huang
Publikováno v:
Toxicological Sciences. 147:466-474
The study objective was to assess age-related changes in glutathione (GSH) adaptive response to cigarette smoke (CS) exposure. Older cigarette smokers show a decline (67%) in lung epithelial lining fluid (ELF) GSH and a 1.8-fold decreased GSH adaptiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4e9747cda24b82e4631b9983c1dc401
https://doi.org/10.1093/toxsci/kfv143
https://doi.org/10.1093/toxsci/kfv143
Autor:
Harry Ischiropoulos, Benoit I. Giasson, Kristen A. Malkus, Richard Lightfoot, Danielle Emille Mor, Neal S. Gould
Publikováno v:
Journal of Biological Chemistry. 289:7929-7934
α-Synuclein aggregation is central to the pathogenesis of several brain disorders. However, the native conformations and functions of this protein in the human brain are not precisely known. The native state of α-synuclein was probed by gel filtrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b67342c05b7e0276a890ba3f183acf74
https://doi.org/10.1074/jbc.c113.538249
https://doi.org/10.1074/jbc.c113.538249
Autor:
Neal S. Gould, Brian J. Day
Publikováno v:
Biochemical Pharmacology. 81:187-193
The lung is unique being exposed directly to the atmospheric environment containing xenobiotics, pathogens, and other agents which are continuously inhaled on a daily basis. Additionally, the lung is exposed to higher ambient oxygen levels which can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6356a65c3c5957317a25389245737503
https://doi.org/10.1016/j.bcp.2010.10.001
https://doi.org/10.1016/j.bcp.2010.10.001