Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Neal S. Burke"'
Autor:
Katrina L. Mealey, Neal S. Burke
Publikováno v:
Journal of Veterinary Pharmacology and Therapeutics.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::83345dcc5339b044d544b15b6b08d985
https://doi.org/10.1111/jvp.13123
https://doi.org/10.1111/jvp.13123
Publikováno v:
Journal of the American Veterinary Medical Association. 259:72-76
OBJECTIVE To determine whether ABCB11930_1931del TC predisposed cats to macrocyclic-lactone toxicosis and the frequency of the ABCB11930_1931del TC gene mutation in banked feline DNA samples. SAMPLE DNA samples from 5 cats presented for neurologic cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8fd434bb8f0ff6b97afcf5a4c7aee904
https://doi.org/10.2460/javma.259.1.72
https://doi.org/10.2460/javma.259.1.72
Publikováno v:
Journal of the American Veterinary Medical Association. 259(1)
To determine whetherDNA samples from 5 cats presented for neurologic clinical signs presumed to be caused by exposure to macrocyclic lactones and 1,006 banked feline DNA samples.The medical history pertaining to 5 cats was obtained from veterinarians
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e2e88ef88cbcf1d41972d6e2a85ec897
https://pubmed.ncbi.nlm.nih.gov/34125616
https://pubmed.ncbi.nlm.nih.gov/34125616
Autor:
Michael H. Court, Katrina L. Mealey, Nicolas F. Villarino, Ana Petra Costa, Neal S. Burke, Zhaohui Zhu
Publikováno v:
Drug Metabolism and Disposition
Drug binding to plasma proteins is routinely determined during drug development. Albumin polymorphisms c.1075G>T (p.Ala359Ser) and c.1422A>T (p.Glu474Asp) were previously shown to alter plasma protein binding of a drug candidate (D01-4582, 4-[1-[3-ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8021fe8b2275b4621bcf143534767d65
https://doi.org/10.1124/dmd.119.087304
https://doi.org/10.1124/dmd.119.087304
Publikováno v:
Journal of Veterinary Pharmacology and Therapeutics. 40:545-551
P-glycoprotein (P-gp), encoded by the ABCB1 (MDR1) gene, dramatically impacts drug disposition. P-gp is expressed in the intestines, biliary canaliculi, renal tubules, and brain capillaries where it functions to efflux substrate drugs. In this capaci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e897c9f82a36192d865e6b8274d11481
https://doi.org/10.1111/jvp.12390
https://doi.org/10.1111/jvp.12390
Publikováno v:
J Vet Pharmacol Ther
Orosomucoid polymorphisms influence plasma drug binding in humans; however, canine variants and their effect on drug plasma protein binding have not yet been reported. In this study, the orosomucoid gene (ORM1) was sequenced in 100 dogs to identify t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1e22a2a4a1bfaad1a6ecb5e4090ef01
https://pubmed.ncbi.nlm.nih.gov/32744755
https://pubmed.ncbi.nlm.nih.gov/32744755
Autor:
Neal S. Burke, Rance K. Sellon, Janean Fidel, Camille C. Hanot, Laura A. White, Katrina L. Mealey
Publikováno v:
Journal of veterinary pharmacology and therapeuticsREFERENCES. 43(2)
Prednisone resistance develops rapidly and essentially universally when dogs with lymphoma are treated with corticosteroids. We investigated naturally occurring mechanisms of prednisone resistance in seven dogs with naive multicentric lymphoma, treat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b35e27ac43af4cb311d418932aec8709
https://pubmed.ncbi.nlm.nih.gov/31943234
https://pubmed.ncbi.nlm.nih.gov/31943234
Autor:
Katrina L. Mealey, Neal S. Burke
Publikováno v:
Journal of Veterinary Pharmacology and Therapeutics. 38:429-433
The aim of this study was to sequence all exons of the ABCB1 (MDR1) gene in cats that had experienced adverse reactions to P-glycoprotein substrate drugs (phenotyped cats). Eight phenotyped cats were included in the study consisting of eight cats tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54d238f88a9dd984021bb8ee80d973de
https://doi.org/10.1111/jvp.12212
https://doi.org/10.1111/jvp.12212
Autor:
Robert M. Duvoisin, Brian T. Reed, R. Lane Brown, Wei Hong Xiong, Neal S. Burke, Catherine W. Morgans
Publikováno v:
Investigative Ophthalmology & Visual Science. 56:1367-1373
Administration of voriconazole, an antifungal triazole, causes transient visual disturbances in patients and attenuates the b-wave of the ERG. We sought to identify the retinal target of voriconazole underlying the effect on the ERG b-wave.Electroret
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27ebe9c7be581e8dadb56cfd47ecfbe1
https://doi.org/10.1167/iovs.14-15270
https://doi.org/10.1167/iovs.14-15270
Autor:
Tania E Perez, Neal S. Burke, Michael H. Court, Tamara Grubb, Stephen A. Greene, Katrina L. Mealey
Objective Variants in the MC1R gene have been associated with red hair color and sensitivity to pain in humans. The study objective was to determine if a relationship exists between MC1R genotype and physiological thermal or mechanical nociceptive th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a62308a03ee557901557e7448e6c2ab7
https://europepmc.org/articles/PMC5461180/
https://europepmc.org/articles/PMC5461180/
