Zobrazeno 1 - 10
of 383
pro vyhledávání: '"Neal R Swerdlow"'
Autor:
Junghee Lee, Michael F Green, Keith H Nuechterlein, Neal R Swerdlow, Tiffany A Greenwood, Gerhard S Hellemann, Laura C Lazzeroni, Gregory A Light, Allen D Radant, Larry J Seidman, Larry J Siever, Jeremy M Silverman, Joyce Sprock, William S Stone, Catherine A Sugar, Debby W Tsuang, Ming T Tsuang, Bruce I Turetsky, Ruben C Gur, Raquel E Gur, David L Braff
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0232855 (2020)
Recently emerging evidence indicates accelerated age-related changes in the structure and function of the brain in schizophrenia, raising a question about its potential consequences on cognitive function. Using a large sample of schizophrenia patient
Externí odkaz:
https://doaj.org/article/1500c5e4b8c84ada8bd264b39db08317
Publikováno v:
Frontiers in Psychiatry, Vol 5 (2014)
Cognitive deficits limit psychosocial functioning in schizophrenia. For many patients, cognitive remediation approaches have yielded encouraging results. Nevertheless, therapeutic response is variable, and outcome studies consistently identify indivi
Externí odkaz:
https://doaj.org/article/2ac56456f67f4cb3a1b77c55b19544e8
Autor:
Gregory A Light, Neal R Swerdlow, Anthony J Rissling, Allen Radant, Catherine A Sugar, Joyce Sprock, Marlena Pela, Mark A Geyer, David L Braff
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e39434 (2012)
BackgroundEndophenotypes are quantitative, laboratory-based measures representing intermediate links in the pathways between genetic variation and the clinical expression of a disorder. Ideal endophenotypes exhibit deficits in patients, are stable ov
Externí odkaz:
https://doaj.org/article/283a60623ceb4f699fbbcd6c24c737f8
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e29630 (2012)
While it is clear that schizophrenia is highly heritable, the genetic basis of this heritability is complex. Human genetic, brain imaging, and model organism studies have met with only modest gains. A complementary research tactic is to evaluate the
Externí odkaz:
https://doaj.org/article/84ce9dd35eb34872be89be6fdbb84527
Autor:
Yash B. Joshi, Juan L. Molina, David L. Braff, Michael F. Green, Ruben C. Gur, Raquel E. Gur, Keith H. Nuechterlein, William S. Stone, Tiffany A. Greenwood, Laura C. Lazzeroni, Allen D. Radant, Jeremy M. Silverman, Joyce Sprock, Catherine A. Sugar, Debby W. Tsuang, Ming T. Tsuang, Bruce I. Turetsky, Neal R. Swerdlow, Gregory A. Light
Publikováno v:
American Journal of Psychiatry.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc880cd27cb18e2cb387268e9762535c
https://doi.org/10.1176/appi.ajp.20220649
https://doi.org/10.1176/appi.ajp.20220649
Autor:
Savita G. Bhakta, James F. Cavanagh, Jo A. Talledo, Juliana E. Kotz, Lindsay Benster, Benjamin Z. Roberts, John A. Nungaray, Jonathan L. Brigman, Gregory A. Light, Neal R. Swerdlow, Jared W. Young
Publikováno v:
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, vol 47, iss 5
Neuropsychopharmacology
Neuropsychopharmacology
The poor translatability between preclinical and clinical drug trials has limited pro-cognitive therapeutic development. Future pro-cognitive drug trials should use translatable cross-species cognitive tasks with biomarkers (1) relevant to specific c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80235699ed0326d5d43e5a8e70897986
https://doi.org/10.1038/s41386-021-01257-2
https://doi.org/10.1038/s41386-021-01257-2
Autor:
Neal R. Swerdlow, Yash B. Joshi, Joyce Sprock, Jo Talledo, Juan L. Molina, Lisa Delano-Wood, Dylan Iwanaga, Juliana E. Kotz, Steven Huege, Gabriel C. Léger, Gregory A. Light
Publikováno v:
Journal of Alzheimer's disease : JAD. 91(1)
Background: The uncompetitive NMDA antagonist, memantine (MEM), enhances prepulse inhibition of startle (PPI) across species. MEM is used to treat Alzheimer’s disease (AD); conceivably, its acute impact on PPI might be used to predict a patient’s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bb1166f4cc1a2eba8bd172f71db6443
https://pubmed.ncbi.nlm.nih.gov/36404550
https://pubmed.ncbi.nlm.nih.gov/36404550
Autor:
Joyce Sprock, Debby W. Tsuang, Raquel E. Gur, Yash B. Joshi, Catherine A. Sugar, Laura C. Lazzeroni, Allen D. Radant, William S. Stone, Neal R. Swerdlow, Ming T. Tsuang, David L. Braff, Keith H. Nuechterlein, Bruce I. Turetsky, Michael F. Green, Juan L. Molina, Laura R MacDonald, Michael L. Thomas, Ruben C. Gur, Gregory A. Light, Tiffany A. Greenwood, Jeremy M. Silverman, John Nungaray
Publikováno v:
Am J Psychiatry
OBJECTIVE: Many psychotropic medications used to treat schizophrenia have significant anticholinergic properties, which are linked to cognitive impairment and dementia risk in healthy subjects. Clarifying the impact of cognitive impairment attributab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1152c4f9927b2c34f985e489e5461c73
https://doi.org/10.1176/appi.ajp.2020.20081212
https://doi.org/10.1176/appi.ajp.2020.20081212
Autor:
Jared W. Young, Sarah L. Olguin, Jonathan L. Brigman, Richard F. Sharp, Neal R. Swerdlow, James F. Cavanagh, David Gregg, Gregory A. Light, Andrew W. Bismark, Savita G. Bhakta
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-11 (2021)
Translational Psychiatry
Translational psychiatry, vol 11, iss 1
Translational Psychiatry
Translational psychiatry, vol 11, iss 1
There has been a fundamental failure to translate preclinically supported research into clinically efficacious treatments for psychiatric disorders. One of the greatest impediments toward improving this species gap has been the difficulty of identify
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e02eff627f7b1a8b5b70573fbf97ede8
https://doaj.org/article/bb1b45e7bda047b0956a1049197f4bec
https://doaj.org/article/bb1b45e7bda047b0956a1049197f4bec
Abnormal Effective Connectivity Underlying Auditory Mismatch Negativity Impairments in Schizophrenia
Autor:
Joyce Sprock, Daisuke Koshiyama, Makoto Miyakoshi, Kumiko Tanaka-Koshiyama, Neal R. Swerdlow, Juan L. Molina, Gregory A. Light, David L. Braff, Yash B. Joshi
Publikováno v:
Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. 5:1028-1039
Background Auditory mismatch negativity (MMN) is a translatable event-related potential biomarker, and its reduction in schizophrenia is associated with the severity of clinical symptoms. While MMN recorded at the scalp is generated by a distributed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f08eef71123cb6f10cec7a470a5e576
https://doi.org/10.1016/j.bpsc.2020.05.011
https://doi.org/10.1016/j.bpsc.2020.05.011