Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Neal N. Iwakoshi"'
Autor:
Jaclyn R. Espinosa, Danny Mou, Bartley W. Adams, Louis R. DiBernardo, Andrea L. MacDonald, MacKenzie McRae, Allison N. Miller, Mingqing Song, Linda L. Stempora, Jun Wang, Neal N. Iwakoshi, Allan D. Kirk
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
CD28:CD80/86 pathway costimulation blockade (CoB) with the CD80/86-specific fusion protein CTLA4-Ig prevents T cell-mediated allograft rejection in mice. However, in humans, transplantation with CoB has been hampered by CoB-resistant rejection (CoBRR
Externí odkaz:
https://doaj.org/article/9b50cf9d8dea4c1f9954c7be7dcd7634
Autor:
Krystalyn E. Hudson, Jeanne E. Hendrickson, Chantel M. Cadwell, Neal N. Iwakoshi, James C. Zimring
Publikováno v:
Haematologica, Vol 97, Iss 12 (2012)
Background Breakdown of humoral tolerance to RBC antigens may lead to autoimmune hemolytic anemia, a severe and sometimes fatal disease. The underlying mechanisms behind the breakdown of humoral tolerance to RBC antigens are poorly understood.Design
Externí odkaz:
https://doaj.org/article/d4bb21e0b43d452aaca7e68104c9b3f7
Publikováno v:
Nature immunology. 21(9)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6a22ce3f822d48e949d91968e6639135
https://pubmed.ncbi.nlm.nih.gov/33184511
https://pubmed.ncbi.nlm.nih.gov/33184511
Publikováno v:
PLoS Pathogens, Vol 5, Iss 11, p e1000677 (2009)
Gammaherpesviruses chronically infect their host and are tightly associated with the development of lymphoproliferative diseases and lymphomas, as well as several other types of cancer. Mechanisms involved in maintaining chronic gammaherpesvirus infe
Externí odkaz:
https://doaj.org/article/350051a9634e48869a96fe2701458c6b
Publikováno v:
Nature Immunology. 22:100-100
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8a6d6e7d616232ccd4c6ea6aa4d65e8
https://doi.org/10.1038/s41590-020-00837-6
https://doi.org/10.1038/s41590-020-00837-6
Autor:
C. Burghuber, Alton B. Farris, Frances M. Saccoccio, Sallie R. Permar, Stuart J. Knechtle, Frank V. Leopardi, Jean Kwun, M. Song, Brian Ezekian, Adriana C Gibby, Miriam Manook, Jennifer A. Jenks, Neal N. Iwakoshi
Publikováno v:
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 19(3)
Previous evidence suggests that a homeostatic germinal center (GC) response may limit bortezomib desensitization therapy. We evaluated the combination of costimulation blockade with bortezomib in a sensitized non-human primate kidney transplant model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40f3bd30dacc08bdb04c96208a1b473d
https://pubmed.ncbi.nlm.nih.gov/30102844
https://pubmed.ncbi.nlm.nih.gov/30102844
Publikováno v:
Journal of Surgical Research. 196:241-246
Background Belatacept, a B7-specific fusion protein, blocks CD28-B7 costimulation and prevents kidney allograft rejection. However, it is ineffective in a sizable minority of patients. Although T-cell receptor and CD28 engagement are known to initiat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90fc92e6b77aea1e473dfc5849781c07
https://doi.org/10.1016/j.jss.2015.02.033
https://doi.org/10.1016/j.jss.2015.02.033
Autor:
Melissa A. Willman, Norma S. Kenyon, Susan A. Safley, Stephanie Duncanson, I. Raul Badell, Collin J. Weber, Dora M. Berman, Athanassios Sambanis, Robert W. Holdcraft, Lawrence S. Gazda, Camillo Ricordi, Neal N. Iwakoshi, Peter Thompson, Graham F. Barber
Publikováno v:
Xenotransplantation. 25(6)
Background Xenogeneic donors would provide an unlimited source of islets for the treatment of type 1 diabetes (T1D). The goal of this study was to assess the function of microencapsulated adult porcine islets (APIs) transplanted ip in streptozotocin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dab67ceb26e174914f027a5f69f9e34
https://pubmed.ncbi.nlm.nih.gov/30117193
https://pubmed.ncbi.nlm.nih.gov/30117193
Publikováno v:
Journal of Biological Chemistry. 289:23629-23640
Although it is known that the unfolded protein response (UPR) plays a significant role in the process of plasma cell differentiation, the contribution of the individual sensors of the UPR to this process remains unclear. In this study we examine the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83cd21754d4ee5d1d8625352e4996168
https://doi.org/10.1074/jbc.m114.569376
https://doi.org/10.1074/jbc.m114.569376
Autor:
Allan D. Kirk, Jean Kwun, Adriana C Gibby, Stuart J. Knechtle, Jung Joo Hong, Francois Villinger, Eugenia J. Kim, Alton B. Farris, Neal N. Iwakoshi
Publikováno v:
American Journal of Transplantation. 14:59-69
De novo donor-specific antibody (DSA) after organ transplantation promotes antibody-mediated rejection (AMR) and causes late graft loss. Previously, we demonstrated that depletion using anti-CD3 immunotoxin (IT) combined with tacrolimus and alefacept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0d4ee19797366ca4e160539346fc22e
https://doi.org/10.1111/ajt.12526
https://doi.org/10.1111/ajt.12526