Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Neal LeLeiko"'
Autor:
David J Cutler, Michael E Zwick, David T Okou, Sampath Prahalad, Thomas Walters, Stephen L Guthery, Marla Dubinsky, Robert Baldassano, Wallace V Crandall, Joel Rosh, James Markowitz, Michael Stephens, Richard Kellermayer, Marian Pfefferkorn, Melvin B Heyman, Neal LeLeiko, David Mack, Dedrick Moulton, Michael D Kappelman, Archana Kumar, Jarod Prince, Promita Bose, Kajari Mondal, Dhanya Ramachandran, John F Bohnsack, Anne M Griffiths, Yael Haberman, Jonah Essers, Susan D Thompson, Bruce Aronow, David J Keljo, Jeffrey S Hyams, Lee A Denson, PRO-KIIDS Research Group, Subra Kugathasan
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0128074 (2015)
The inflammatory bowel diseases (IBD) are common, complex disorders in which genetic and environmental factors are believed to interact leading to chronic inflammatory responses against the gut microbiota. Earlier genetic studies performed in mostly
Externí odkaz:
https://doaj.org/article/462513746631471c94b8d1e45ba06f40
Autor:
Boyko Kabakchiev, Dan Turner, Jeffrey Hyams, David Mack, Neal Leleiko, Wallace Crandall, James Markowitz, Anthony R Otley, Wei Xu, Pingzhao Hu, Anne M Griffiths, Mark S Silverberg
Publikováno v:
PLoS ONE, Vol 5, Iss 9 (2010)
Microarray analysis of RNA expression allows gross examination of pathways operative in inflammation. We aimed to determine whether genes expressed in whole blood early following initiation of intravenous corticosteroid treatment can be associated wi
Externí odkaz:
https://doaj.org/article/a3d7b9aacfb34159b368c94cbd86a2c0
Autor:
Kaitlin G. Whaley, Ye Xiong, Rebekah Karns, Jeffrey S. Hyams, Subra Kugathasan, Brendan M. Boyle, Thomas D. Walters, Judith Kelsen, Neal LeLeiko, Jason Shapiro, Amanda Waddell, Sejal Fox, Ramona Bezold, Stephanie Bruns, Robin Widing, Yael Haberman, Margaret H. Collins, Tomoyuki Mizuno, Phillip Minar, Geert R. D’Haens, Lee A. Denson, Alexander A. Vinks, Michael J. Rosen
Publikováno v:
Clinical gastroenterology and hepatology. W.B. Saunders Ltd
Background & aims: We aimed to model infliximab (IFX) pharmacokinetics (PK) in pediatric acute severe ulcerative colitis (ASUC) and assess the association between PK parameters, including drug exposure, and clinical response. Methods: We studied a mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8d71bbffe0fb8d027aa8b975ea2652b
http://www.scopus.com/inward/record.url?scp=85144277005&partnerID=8YFLogxK
http://www.scopus.com/inward/record.url?scp=85144277005&partnerID=8YFLogxK
Autor:
Kaitlin Whaley, Vivian Xiong, Rebekah Karns, Jeffrey Hyams, Subra Kugathasan, Brendan Boyle, Tom Walters, Judith Kelsen, Neal LeLeiko, Jason Shapiro, Amanda Waddell, Sejal Fox, Yael Haberman, Phillip Minar, Lee Denson, Geert D’Haens, Alexander Vinks, Michael Rosen
Publikováno v:
Inflammatory Bowel Diseases. 27:S55-S56
Background and Aims 25% of children hospitalized with acute severe ulcerative colitis (ASUC) rescued with infliximab (IFX) at labeled dosing undergo a colectomy prior to discharge. Our aim was to determine whether IFX pharmacokinetics (PK) are associ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d8e58ecbea3bb4d518c9e747ce4b717
https://doi.org/10.1093/ibd/izaa347.132
https://doi.org/10.1093/ibd/izaa347.132
Autor:
Martin Wasser, Osnat Konen, David R Mack, Bob Baldassano, Oren Ledder, Maarten H. Lequin, Jorge Davila, J. Hyams, Johanna C. Escher, Tony Otley, Lissy de Ridder, Shehzad Ahmed Saeed, Emily J. Stenhouse, Daniel A. Lemberg, Victor Navas, Jessie M. Hulst, Eric I Benchimol, Ted Denson, Jared Silverstein, Kathy O'Brien, Anat Ilivitzki, Judith Kelsen, Izabela Herman-Sucharska, Frank M. Ruemmele, Neal Leleiko, Lucia Riaza, Sibylle Koletzko, Elhamy Bekhit, Raanan Shamir, David J. Grand, Doug Moote, Daniel Moses, Sudha Anupindi, Richard K. Russell, Dan Turner, Laureline Berteloo, Michal Amitai
Publikováno v:
JOURNAL OF CROHNS & COLITIS
r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
Fundació Sant Joan de Déu
Journal of Crohn's and Colitis, 12(9), 1073-1078
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname
r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
Fundació Sant Joan de Déu
Journal of Crohn's and Colitis, 12(9), 1073-1078
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname
Objective: There is no standardized endoscopic description of upper gastrointestinal [UGI] disease in Crohn's disease [CD]. We prospectively applied the Simple Endoscopic Score for CD [SES-CD] to the UGI tract as a planned sub-study of the multicentr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::078e991220b9aac1dd67f4848610a592
https://hdl.handle.net/1887/95868
https://hdl.handle.net/1887/95868
Autor:
Evan S. Dellon, David A. Katzka, Margaret H. Collins, Mohamed Hamdani, Sandeep K. Gupta, Ikuo Hirano, Amir Kagalwalla, Jeffrey Lewis, Jonathan Markowitz, Samuel Nurko, John Wo, Evan Dellon, Thirumazhisai S. Gunasekaran, Sandeep Gupta, Brad Pasternak, Mark Ellis, Kathryn Peterson, Gary Falk, John Leung, Laurel Prestridge, Michael Hart, Neal Leleiko, Michael Vaezi, Rebecca Cherry, David Katzka, Keith Friedenberg, Yehudith Assouline-Dayan, Vincent Mukkada
BACKGROUND & AIMS: Pharmacologic treatment of eosinophilic esophagitis (EoE) is limited to off-label use of corticosteroids not optimized for esophageal delivery. We performed a randomized, controlled phase 2 trial to assess the ability of budesonide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45a271715900994d09ac27e0ad023ef4
Autor:
Barbara S. Kirschner, Chunyan Liu, Anthony Otley, Maria Oliva-Hemker, Neal Leleiko, Lee A. Denson, James Markowitz, Wallace Crandall, Dedrick E. Moulton, Michael C. Stephens, Susan S. Baker, Stanley N. Cohen, Marla Dubinsky, Jonathan Evans, David R. Mack, Stephen L. Guthery, Melvin B. Heyman, Richard Kellermayer, Anne M. Griffiths, Jeffrey S. Hyams, Robert N. Baldassano, Subra Kugathasan, David Ziring, Ashish S. Patel, Marian Pfefferkorn, Mi-Ok Kim, Joel R. Rosh, Jonah Essers, Sandra C. Kim, Thomas D. Walters
Publikováno v:
Gastroenterology. 146:383-391
Background & Aims Standard therapy for children newly diagnosed with Crohn's disease (CD) includes early administration of immunomodulators after initial treatment with corticosteroids. We compared the effectiveness of early (≤3 mo after diagnosis)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::510e2e146254bc9f90db0fa6cd394512
https://doi.org/10.1053/j.gastro.2013.10.027
https://doi.org/10.1053/j.gastro.2013.10.027
Autor:
Neal Leleiko, Jeffrey S. Hyams, Harshavardhan Kenche, Sonia Michail, Eytan Wine, Anne M. Griffiths, David R. Mack, Adrienne Stolfi, Dan Turner, Matthew D. Durbin
Publikováno v:
Inflammatory Bowel Diseases. 18:1799-1808
Background: Although the role of microbes in disease pathogenesis is well established, data describing the variability of the vast microbiome in children diagnosed with ulcerative colitis (UC) are lacking. This study characterizes the gut microbiome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b6da0051f77403ab6e96a3c1ac4c3ee
https://doi.org/10.1002/ibd.22860
https://doi.org/10.1002/ibd.22860
Autor:
Cary G. Sauer, David R. Mack, Susan S. Baker, Ashish S. Patel, Nathan Gotman, Robert N. Baldassano, Jeffrey S. Hyams, Ramnik J. Xavier, Sonia Davis Thomas, Subra Kugathasan, Thomas D. Walters, Curtis Huttenhower, Melanie Schirmer, Paul A. Rufo, Neal Leleiko, David J. Keljo, Lee A. Denson, James Markowitz, Anne M. Griffiths, Marian D. Pfefferkorn, Joel R. Rosh, Joshua D. Noe, Maria Oliva-Hemker, Melvin B. Heyman, Hera Vlamakis, Brendan M. Boyle, Anthony R. Otley, Eric A. Franzosa
Publikováno v:
Cell host & microbe, vol 24, iss 4
Evaluating progression risk and determining optimal therapy for ulcerative colitis (UC) is challenging as many patients exhibit incomplete responses to treatment. As part of the PROTECT (Predicting Response to Standardized Colitis Therapy) Study, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3036a8c523390ab8c9bd5f1590346ba
https://doi.org/10.1016/j.chom.2018.09.009
https://doi.org/10.1016/j.chom.2018.09.009
Autor:
David R. Mack, Subra Kugathasan, Marian Pfefferkorn, Trudy Lerer, Anthony Otley, Marsha Kay, Maria Oliva-Hemker, Christine R. Langton, Wallace Crandall, Joel R. Rosh, Dan Turner, Anne M. Griffiths, Ryan Carvalho, Neal Leleiko, Athos Bousvaros, David J. Keljo, Jonathan Evans, Jeffrey S. Hyams, James Markowitz, Petar Mamula
Publikováno v:
Inflammatory Bowel Diseases. 15:1218-1223
Background: We evaluated the psychometric performance of the Pediatric Ulcerative Colitis Activity Index (PUCAI) in a real-life cohort from the Pediatric IBD Collaborative Research Group. Methods: Two consecutive visits of 215 children with ulcerativ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d92b910f9b47949606965fac257ce24b
https://doi.org/10.1002/ibd.20867
https://doi.org/10.1002/ibd.20867