Zobrazeno 1 - 10
of 253
pro vyhledávání: '"Neal K. Devaraj"'
Autor:
Shuaijiang Jin, Roberto J. Brea, Andrew K. Rudd, Stuart P. Moon, Matthew R. Pratt, Neal K. Devaraj
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Sequestration of reactants in lipid vesicles is a strategy prevalent in biological systems to raise the rate and specificity of chemical reactions. Here, the authors show that micelle-assisted reactions facilitate native chemical ligation between a p
Externí odkaz:
https://doaj.org/article/d523faaf6776431fa7a2b80e8cddfeb5
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
The origin of phospholipids, the primary constituents of cell membranes, is uncertain. Here, the authors develop an in vitro system to synthesize phospholipid molecules from water-soluble single-chain amphiphilic precursors via a reaction catalysed b
Externí odkaz:
https://doaj.org/article/89bca9b9c80c40c190a8c51af0b8b13d
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
Cells communicate through chemical and mechanical signals but emulating these in non-living mimics has been challenging. Here the authors present a porous mimic with a DNA-hydrogel ‘nucleus’ that can communicate through diffusive protein signals.
Externí odkaz:
https://doaj.org/article/28734bb4553b4d899cf090598aed3029
Autor:
Alessandro Fracassi, Kira A. Podolsky, Sudip Pandey, Cong Xu, Joshua Hutchings, Soenke Seifert, Carlos R. Baiz, Sunil K. Sinha, Neal K. Devaraj
Publikováno v:
The Journal of Physical Chemistry B. 127:1771-1779
Publikováno v:
Bioconjugate Chemistry. 34:169-173
Conjugating small-molecule ligands to synthetic motifs that can localize to specific organelles or membranes in living cells is a practical approach to develop compounds as chimeric tools or drugs that can manipulate biological processes in a subcell
Autor:
Neal K. Devaraj
Publikováno v:
ACS Central Science, Vol 4, Iss 8, Pp 952-959 (2018)
Externí odkaz:
https://doaj.org/article/2a1f8ff46f214650b0450acde3648d27
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Abstract Protein degradation is a fundamental process in all living cells and is essential to remove both damaged proteins and intact proteins that are no longer needed by the cell. We are interested in creating synthetic genetic circuits that functi
Externí odkaz:
https://doaj.org/article/7864bd636f484af58fd311bfaf3f0ba4
Autor:
Shuaijiang Jin, Roberto J. Brea, Andrew K. Rudd, Stuart P. Moon, Matthew R. Pratt, Neal K. Devaraj
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-2 (2021)
A Correction to this paper has been published: https://doi.org/10.1038/s41467-021-22508-2
Externí odkaz:
https://doaj.org/article/ec3e440211dd48658ef588780b581bba
Autor:
Caroline H. Knittel, Neal K. Devaraj
Publikováno v:
Acc Chem Res
ConspectusThe structural boundaries of living cells are composed of numerous membrane-forming lipids. Lipids not only are crucial for the cellular compartmentalization but also are involved in cell signaling as well as energy storage. Abnormal lipid
Autor:
Roberto J. Brea, Neal K. Devaraj
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-7 (2017)
Molecules that act as both autocatalysts and material precursors offer exciting prospects for self-synthesizing materials. Here, the authors design a triazole peptide that self-replicates and then self-assembles into nanostructures, coupling autocata
Externí odkaz:
https://doaj.org/article/9e2ada1f838c4430a6e9efa70a5f0f0f