Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Neal J. Fazakerley"'
Autor:
Christopher R. Wellaway, Ian R. Baldwin, Paul Bamborough, Daniel Barker, Michelle A. Bartholomew, Chun-wa Chung, Birgit Dümpelfeld, John P. Evans, Neal J. Fazakerley, Paul Homes, Steven P. Keeling, Xiao Q. Lewell, Finlay W. McNab, Joanne Morley, Deborah Needham, Margarete Neu, Antoon J. M. van Oosterhout, Anshu Pal, Friedrich B. M. Reinhard, Francesco Rianjongdee, Craig M. Robertson, Paul Rowland, Rishi R. Shah, Emma B. Sherriff, Lisa A. Sloan, Simon Teague, Daniel A. Thomas, Natalie Wellaway, Justyna Wojno-Picon, James M. Woolven, Diane M. Coe
Publikováno v:
Journal of Medicinal Chemistry. 65:633-664
The Janus family of tyrosine kinases (JAK1, JAK2, JAK3, and TYK2) play an essential role in the receptor signaling of cytokines that have been implicated in the pathogenesis of severe asthma, and there is emerging interest in the development of small
Autor:
Samuel D. L. Holman, Alfie G. Wills, Neal J. Fazakerley, Darren L. Poole, Diane M. Coe, Leonard A. Berlouis, Marc Reid
An electrochemical method for the green and practical synthesis of a broad range of substituted isoxazoline cores is presented. Both aryl and more challenging alkyl aldoximes are converted to the desired isoxazoline in an electrochemically enabled re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d328e135ccc61442e672b5d04100855
https://strathprints.strath.ac.uk/79471/7/Holman_etal_Electrochemical_synthesis_of_isoxazolines.pdf
https://strathprints.strath.ac.uk/79471/7/Holman_etal_Electrochemical_synthesis_of_isoxazolines.pdf
Autor:
Matthew J West, Ciaran P. Seath, John J. Molloy, Alan R. Kennedy, Calum McLaughlin, Neal J. Fazakerley, David J. Nelson, Allan J. B. Watson
Publikováno v:
Journal of the American Chemical Society. 140:126-130
Ligand metathesis of Pd(II) complexes is mechanistically essential for cross-coupling. We present a study of halide→OH anion metathesis of (Ar)Pd(II) complexes using vinylBPin as a bifunctional chemical probe with Pd(II)-dependent cross-coupling pa
Publikováno v:
Angewandte Chemie. 129:1269-1273
Chemoselective Suzuki-Miyaura cross-coupling generally requires a designed deactivation of one nucleophile towards transmetallation. Here we show that boronic acids can be chemoselectively reacted in the presence of ostensibly equivalently reactive b
Autor:
Neal J. Fazakerley, David J. Procter
Publikováno v:
Tetrahedron. 70(39):6911-6930
Despite renewed pleas by the World Health Organisation for action to be taken against antimicrobial resistance, the development of new antibiotics has not kept pace with demand. The pleuromutilin class is vastly under explored and could hold a key we
Autor:
Gail L. Wrigley, Shaun M. Fillery, Barry M. Hayter, Paula Perkins, Jason Grant Kettle, Emma J. Williams, Peter Mark Smith, Mandy L. Crowther, Rebecca J. Burton, Peter Robins, Neal J. Fazakerley, Caroline Anne McMillan
Publikováno v:
Tetrahedron Letters. 54:6900-6904
The highly regioselective Buchwald–Hartwig amination at C-2 of the cheap and readily accessible reagent, 2,4-dichloropyridine with a range of anilines and heterocyclic amines is described. This new methodology is robust and provides a facile access
Publikováno v:
Chemistry - A European Journal. 19:6718-6723
The first enantiospecific total synthesis of the antibacterial natural product (+)-pleuromutilin has been achieved. The approach includes the synthesis of a non-racemic cyclisation substrate from (+)-trans-dihydrocarvone, a highly selective SmI2-medi
Publikováno v:
ChemInform. 47
A general synthetic strategy to access novel tricyclic scaffolds inspired by the antibacterial pleuromutilin is developed.
Publikováno v:
Chemistry (Weinheim an Der Bergstrasse, Germany)
A general synthetic sequence involving simply prepared starting materials provides rapid access to diverse, novel tricyclic architectures inspired by pleuromutilin. SmII‐mediated radical cyclization cascades of dialdehydes, prepared using a new, on
Publikováno v:
ChemInform. 45