Zobrazeno 1 - 10
of 420
pro vyhledávání: '"Neal J Meropol"'
Autor:
Kenneth C Cummings Iii, Tzuyung Doug Kou, Amitabh Chak, Mark D Schluchter, Seunghee Margevicius, Gregory S Cooper, Neal J Meropol, Yaron Perry, Philip A Linden, Linda C Cummings
Publikováno v:
PLoS ONE, Vol 14, Iss 1, p e0211125 (2019)
BackgroundEsophagectomy for esophageal cancer carries high morbidity and mortality, particularly in older patients. Transthoracic esophagectomy allows formal lymphadenectomy, but leads to greater perioperative morbidity and pain than transhiatal esop
Externí odkaz:
https://doaj.org/article/8171fe8d460e4d7796fbfa8a0a0750de
Autor:
Ariel B. Bourla, Neal J. Meropol
Publikováno v:
Digital Health, Vol 7 (2021)
Real world data (RWD) are data relating to patient health status and/or the delivery of health care routinely collected from a variety of sources; real-world evidence (RWE) generated by RWD analyses can become an important component of drug developme
Externí odkaz:
https://doaj.org/article/22c76d71443141fbafa3f2bd70840458
Autor:
Patricia Luhn, Deborah Kuk, Gillis Carrigan, Nathan Nussbaum, Rachael Sorg, Rebecca Rohrer, Melisa G. Tucker, Brandon Arnieri, Michael D. Taylor, Neal J. Meropol
Publikováno v:
BMC Medical Research Methodology, Vol 19, Iss 1, Pp 1-7 (2019)
Abstract Background The use of real-world data to generate evidence requires careful assessment and validation of critical variables before drawing clinical conclusions. Prospective clinical trial data suggest that anatomic origin of colon cancer imp
Externí odkaz:
https://doaj.org/article/d9aedffac4bc4ed68ba506bd0abb221b
Autor:
Wafik S. El-Deiry, Arthur Winer, Michael Slifker, Stanford Taylor, Blythe J. S. Adamson, Neal J. Meropol, Eric A. Ross
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Background: The prognosis of patients with metastatic colorectal cancer (mCRC) is poor, especially after failure of initial systemic therapy. The VELOUR study showed modestly prolonged overall survival (OS) with ziv-aflibercept plus 5-fluorouracil, l
Externí odkaz:
https://doaj.org/article/f6acd938198a460c9d41779080f7fb6e
Autor:
Steven J. Harper, Al Bowen Benson, Neal J. Meropol, Bruce J. Giantonio, Peter J. O'Dwyer, Pramila Ramani, Alex H.R. Varey, Kirsty E. Symonds, Paul J. Catalano, David O. Bates
Purpose: Bevacizumab improves survival for patients with metastatic colorectal cancer with chemotherapy, but no proven predictive markers exist. The VEGF-A splice form, VEGF165b, anti-angiogenic in animal models, binds bevacizumab. We tested the hypo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a66271b1b11cdb63bc49f9f6383be76
https://doi.org/10.1158/1078-0432.c.6520919
https://doi.org/10.1158/1078-0432.c.6520919
Autor:
Zhenghe Wang, Jennifer R. Eads, Neal J. Meropol, Sanford D. Markowitz, David L. Bajor, Yan Xu, Martina Veigl, Shaveta Vinayak, Smitha S. Krishnamurthi, Joel Saltzman, Jill S. Barnholtz-Sloan, Ronald A. Conlon, Gino Cioffi, Yujun Hao, Janet M. Wang, Zhanwen Du, Shashank Gorityala, J. Eva Selfridge, Yicheng Chen, Xiujing Feng, Yiqing Zhao
Supplementary Figures 1-6 and Tables 1-3. Figure S1. PIK3CA mutant cells are more sensitive to a glutaminase inhibitor CB-839 than their WT counterparts. Figure S2. CB-839 enhances 5-FU tumor inhibitory effect in PIK3CA mutant CRC. Figure S3. Genes a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00979391b3ffe7f859a4ff0835457ca3
https://doi.org/10.1158/0008-5472.22426516.v1
https://doi.org/10.1158/0008-5472.22426516.v1
Autor:
Zhenghe Wang, Jennifer R. Eads, Neal J. Meropol, Sanford D. Markowitz, David L. Bajor, Yan Xu, Martina Veigl, Shaveta Vinayak, Smitha S. Krishnamurthi, Joel Saltzman, Jill S. Barnholtz-Sloan, Ronald A. Conlon, Gino Cioffi, Yujun Hao, Janet M. Wang, Zhanwen Du, Shashank Gorityala, J. Eva Selfridge, Yicheng Chen, Xiujing Feng, Yiqing Zhao
PIK3CA encodes the p110α catalytic subunit of PI3K and is frequently mutated in human cancers, including ∼30% of colorectal cancer. Oncogenic mutations in PIK3CA render colorectal cancers more dependent on glutamine. Here we report that the glutam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3631a7b60d939b8b71154c64bad51452
https://doi.org/10.1158/0008-5472.c.6512362.v1
https://doi.org/10.1158/0008-5472.c.6512362.v1
Autor:
Steven J. Harper, Al Bowen Benson, Neal J. Meropol, Bruce J. Giantonio, Peter J. O'Dwyer, Pramila Ramani, Alex H.R. Varey, Kirsty E. Symonds, Paul J. Catalano, David O. Bates
PDF file - 37K, Comparison of study cases and overall patient population
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::613a93b2cfc2385e5d153b0e59aad620
https://doi.org/10.1158/1078-0432.22446920
https://doi.org/10.1158/1078-0432.22446920
Autor:
Steven J. Harper, Al Bowen Benson, Neal J. Meropol, Bruce J. Giantonio, Peter J. O'Dwyer, Pramila Ramani, Alex H.R. Varey, Kirsty E. Symonds, Paul J. Catalano, David O. Bates
PDF file - 260K, Scoring of immunohistochemically stained samples
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91c48cd4d52d45d22683b548e91b6c39
https://doi.org/10.1158/1078-0432.22446923
https://doi.org/10.1158/1078-0432.22446923
Autor:
S. Mark O'Hara, Leon W.M.M. Terstappen, Mark C. Connelly, Jose G. Moreno, Steven J. Cohen, Louis M. Weiner, Neal J. Meropol, Kenneth J. Pienta, Gerald V. Doyle, M. Craig Miller, Bradley W. Foulk, Daniel R. Zweitzig, Denis A. Smirnov
Metastases from primary tumors are responsible for most cancer deaths. It has been shown that circulating tumor cells (CTCs) can be detected in the peripheral blood of patients with a variety of metastatic cancers and that the presence of these cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4743032c9cb763ba033668201c815376
https://doi.org/10.1158/0008-5472.c.6493686.v1
https://doi.org/10.1158/0008-5472.c.6493686.v1