Zobrazeno 1 - 10 of 36 pro vyhledávání: '"Neal I. Callaghan"'
1
Akademický článek
Tmem65 is critical for the structure and function of the intercalated discs in mouse hearts
Autor: Allen C. T. Teng, Liyang Gu, Michelle Di Paola, Robert Lakin, Zachary J. Williams, Aaron Au, Wenliang Chen, Neal I. Callaghan, Farigol Hakem Zadeh, Yu-Qing Zhou, Meena Fatah, Diptendu Chatterjee, L. Jane Jourdan, Jack Liu, Craig A. Simmons, Thomas Kislinger, Christopher M. Yip, Peter H. Backx, Robert G. Gourdie, Robert M. Hamilton, Anthony O. Gramolini
Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
The intercalated disc (ICD) is a membrane structure of the cardiac muscle involved in normal heart function. Here the authors report that knockdown of the ICD-bound transmembrane protein 65 results in impaired ICD structure, abnormal cardiac electrop
Externí odkaz: https://doaj.org/article/aafde2c6ca28412ea8f19a14b47c1f34
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2
Akademický článek
Harnessing conserved signaling and metabolic pathways to enhance the maturation of functional engineered tissues
Autor: Neal I. Callaghan, Lauren J. Durland, Ronald G. Ireland, J. Paul Santerre, Craig A. Simmons, Locke Davenport Huyer
Publikováno v: npj Regenerative Medicine, Vol 7, Iss 1, Pp 1-25 (2022)
Abstract The development of induced-pluripotent stem cell (iPSC)-derived cell types offers promise for basic science, drug testing, disease modeling, personalized medicine, and translatable cell therapies across many tissue types. However, in practic
Externí odkaz: https://doaj.org/article/a9983e6cae9d46ba83d7a5e678f0381c
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3
Akademický článek
Interrelationship Between Contractility, Protein Synthesis and Metabolism in Mantle of Juvenile Cuttlefish (Sepia officinalis)
Autor: Simon G. Lamarre, Tyson J. MacCormack, Émilie Bourloutski, Neal I. Callaghan, Vanessa D. Pinto, José P. Andrade, Antonio V. Sykes, William R. Driedzic
Publikováno v: Frontiers in Physiology, Vol 10 (2019)
Young juvenile cuttlefish (Sepia officinalis) can grow at rates as high as 12% body weight per day. How the metabolic demands of such a massive growth rate impacts muscle performance that competes for ATP is unknown. Here, we integrate aspects of con
Externí odkaz: https://doaj.org/article/b7cf13deb7904c3d9f3d3464b641904c
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4
Akademický článek
Modeling cardiac complexity: Advancements in myocardial models and analytical techniques for physiological investigation and therapeutic development in vitro
Autor: Neal I. Callaghan, Sina Hadipour-Lakmehsari, Shin-Haw Lee, Anthony O. Gramolini, Craig A. Simmons
Publikováno v: APL Bioengineering, Vol 3, Iss 1, Pp 011501-011501-21 (2019)
Cardiomyopathies, heart failure, and arrhythmias or conduction blockages impact millions of patients worldwide and are associated with marked increases in sudden cardiac death, decline in the quality of life, and the induction of secondary patholog
Externí odkaz: https://doaj.org/article/bfe747352161413faaae79f5e2b8863e
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6
Abstract P2018: Tmem65 Is Critical For The Structure And Function Of The Intercalated Discs In Mouse Hearts
Autor: Allen Teng, Liyang Gu, Michelle Di Paola, Robert Lakin, Zachary Williams, Aaron Au, WENLIANG CHEN, Neal I Callaghan, Farigol Hakem Zadeh, YU-QING ZHOU, Meena Fatah, Diptendu Chatterjee, Jane Jourdan, Liu Jack, Craig A Simmons, Thomas Kislinger, Christopher Yip, Peter Backx, Robert G Gourdie, Robert M Hamilton, Anthony Gramolini
Publikováno v: Circulation Research. 131
The intercalated disc (ICD) is unique membrane structure that is indispensable to normal heart function, yet its structural organization is not completely understood. Previously, we showed that the ICD-bound transmembrane protein 65 (Tmem65) was requ
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6c452fcc3f0257c9974d3ec4705c6a96
https://doi.org/10.1161/res.131.suppl_1.p2018
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8
Functional culture and in vitro genetic and small-molecule manipulation of adult mouse cardiomyocytes
Autor: Christopher M. Yip, Shin-Haw Lee, Anthony O. Gramolini, Neal I. Callaghan, Mansoor Husain, Sina Hadipour-Lakmehsari, Amine Driouchi, Craig A. Simmons, Xavier Alexander Lee, M. Ahsan Siraj
Publikováno v: Communications Biology, Vol 3, Iss 1, Pp 1-10 (2020)
Communications Biology
Primary adult cardiomyocyte (aCM) represent the mature form of myocytes found in the adult heart. However, culture of aCMs in particular is challenged by poor survival and loss of phenotype, rendering extended in vitro experiments unfeasible. Here, w
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5211222742dc90446fc6d4def52e26b8
http://link.springer.com/article/10.1038/s42003-020-0946-9
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10
Reversion to developmental pathways underlies rapid arm regeneration in juvenile European cuttlefish, Sepia officinalis (Linnaeus 1758)
Autor: Ana R. Oliveira, Emilie Bourloutski, Neal I. Callaghan, Simon G. Lamarre, António V. Sykes, Tyson J. MacCormack, Juan C. Capaz, William R. Driedzic
Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Coleoid cephalopods, including the European cuttlefish (Sepia officinalis), possess the remarkable ability to fully regenerate an amputated arm with no apparent fibrosis or loss of function. In model organisms, regeneration usually occurs as the indu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f3657438eb1340351643c5005053432
https://doi.org/10.1002/jez.b.22849
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