Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Neal I Walker"'
Autor:
Daniel D Buchanan, Kevin Sweet, Musa Drini, Mark A Jenkins, Aung Ko Win, Dallas R English, Michael D Walsh, Mark Clendenning, Diane M McKeone, Rhiannon J Walters, Aedan Roberts, Sally-Ann Pearson, Erika Pavluk, John L Hopper, Michael R Gattas, Jack Goldblatt, Jill George, Graeme K Suthers, Kerry D Phillips, Sonja Woodall, Julie Arnold, Kathy Tucker, Amanda Muir, Michael Field, Sian Greening, Steven Gallinger, Renee Perrier, John A Baron, John D Potter, Robert Haile, Wendy Frankel, Albert de la Chapelle, Finlay Macrae, Christophe Rosty, Neal I Walker, Susan Parry, Joanne P Young
Publikováno v:
PLoS ONE, Vol 5, Iss 7, p e11636 (2010)
Patients with multiple serrated polyps are at an increased risk for developing colorectal cancer (CRC). Recent reports have linked cigarette smoking with the subset of CRC that develops from serrated polyps. The aim of this work therefore was to inve
Externí odkaz:
https://doaj.org/article/17b278d16068450e836620fc118aeb7e
Autor:
Charles S. Fuchs, Carino Gurjao, Andrew T. Chan, Tabitha A. Harrison, Kenji Fujiyoshi, Susan Bullman, Tomotaka Ugai, Mingyang Song, Reiko Nishihara, Kana Wu, Tsuyoshi Hamada, Kristen Felt, Jochen K. Lennerz, Mai Chan Lau, Jennifer Borowsky, Annacarolina da Silva, Kimmie Ng, Marios Giannakis, Shuji Ogino, Jonathan A. Nowak, Vicki L. J. Whitehall, Melissa Zhao, Edward Giovannucci, Sara A. Väyrynen, Xuehong Zhang, Ian Brown, Mark Bettington, Tyler S. Twombly, Koichiro Haruki, Jeffrey A. Meyerhardt, Kosuke Mima, Neal I. Walker, Ulrike Peters, Juha P. Väyrynen, Wendy S. Garrett, Andressa Dias Costa, Barbara A. Leggett, Amanda I. Phipps, Curtis Huttenhower, Gordon J. Freeman, Kota Arima
Publikováno v:
Clinical Cancer Research. 27:2816-2826
Purpose: While evidence indicates that Fusobacterium nucleatum (F. nucleatum) may promote colorectal carcinogenesis through its suppressive effect on T-cell–mediated antitumor immunity, the specific T-cell subsets involved remain uncertain. Experim
Autor:
Vicki L. J. Whitehall, Mark Bettington, Tony Rahman, Cheng Liu, Ian Brown, Sally-Ann Pearson, John Croese, Christophe Rosty, Neal I. Walker, Diane McKeone, Barbara A. Leggett
Publikováno v:
Journal of Clinical Gastroenterology. 53:e113-e116
To provide preliminary evidence that sessile serrated adenomas (SSA) are low-risk polyps in young patients. SSAs are the dominant polyp of the serrated neoplasia pathway and as such are the precursor of up to 20% of colorectal carcinomas (CRC). Up to
Autor:
Neal I. Walker, Vicki L. J. Whitehall, Sally-Ann Pearson, Christophe Rosty, Barbara A. Leggett, Diane McKeone, Mark Bettington
Publikováno v:
Histopathology. 73:1023-1029
Traditional serrated adenoma (TSA) is the least common subtype of serrated colorectal polyp. Large protuberant lesions are easily recognised; however, the origins of TSAs are not known, and early forms have not been described. Some large TSAs present
Autor:
Mark Bettington, Diane McKeone, Cheng Liu, Troy Dumenil, Ian Brown, Neal I. Walker, Catherine Bond, Lochlan Fennell, Vicki L. J. Whitehall, Sally-Ann Pearson, Barbara A. Leggett, Jennifer Borowsky, Christophe Rosty
Publikováno v:
Modern Pathology. 31:495-504
Conventional adenomas are initiated by APC gene mutation that activates the WNT signal. Serrated neoplasia is commonly initiated by BRAF or KRAS mutation. WNT pathway activation may also occur, however, to what extent this is owing to APC mutation is
Autor:
Cheng Liu, Barbara A. Leggett, Christophe Rosty, Mark Bettington, Neal I. Walker, Vicki L. J. Whitehall
Publikováno v:
Modern Pathology
Sessile serrated adenomas are the precursor polyp of approximately 20% of colorectal carcinomas. Sessile serrated adenomas with dysplasia are rarely encountered and represent an intermediate step to malignant progression, frequently associated with l
Autor:
Vicki L. J. Whitehall, Ann Vandeleur, John Croese, Neal I. Walker, Mark Bettington, Tony Rahman, Barbara A. Leggett
Publikováno v:
Internal Medicine Journal. 47:318-323
Background: Sessile serrated adenomas (SSA) are the polyp precursor of 15–20% of colorectal carcinomas. There is debate about their prevalence and increasing discussion about the need for a serrated polyp detection rate as a quality indicator for c
Autor:
Vicki L. J. Whitehall, Mark Bettington, Joel Dwine, Cheng Liu, Barbara A. Leggett, Lochlan Fennell, Neal I. Walker
Publikováno v:
Clinical Epigenetics
Background Sessile serrated adenomas (SSAs) are common polyps which give rise to 20–30% of colorectal cancer (CRC). SSAs display clinicopathologic features which present challenges in surveillance, including overrepresentation in young patients, pr
Publikováno v:
Pathology. 51:S157-S158
Autor:
Christophe Rosty, Barbara A. Leggett, Vicki L. J. Whitehall, Neal I. Walker, Kerenaftali Klein, Andrew D. Clouston, Mark Bettington, Sally-Ann Pearson, Diane McKeone, Ian Brown
Publikováno v:
Histopathology. 68:578-587
Most colorectal polyps are classified readily, but a subset of tubulovillous adenomas (TVA) with prominent serrated architecture causes diagnostic confusion. We aimed to (i) identify histological features that separate serrated TVAs from both convent