Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Neal F. Osborne"'
Autor:
Robert Southgate, Neal F. Osborne
Publikováno v:
Kirk-Othmer Encyclopedia of Chemical Technology
In the period up to 1970 most β-lactam research was concerned with the penicillin and cephalosporin group of antibiotics. Since that time, however, a wide variety of new mono- and bicyclic β-lactam structures have been described. The carbapenems or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::902b096be83e6ca9d48a1197fe85a923
https://doi.org/10.1002/0471238961.0301180219152120.a01
https://doi.org/10.1002/0471238961.0301180219152120.a01
Autor:
R. Sutherland, M. J. Basker, Robert Southgate, Michael J. Pearson, Terence C. Smale, Patricia Tolliday, John H. C. Nayler, Edward G. Brain, Neal F. Osborne, A. J. Eglington
Publikováno v:
Journal of medicinal chemistry. 20(8)
tert-Butyl 7beta-aminoceph-3-em-4-carboxylates carrying either benzyl or 3-pyridylmethyl substituents at position 3 have been prepared by a multistep modification of the penicillin nucleus. Acylation of either amine, followed by deprotection, gave a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea43a247f56a9e0031467a0a576b26b7
https://pubmed.ncbi.nlm.nih.gov/894679
https://pubmed.ncbi.nlm.nih.gov/894679
Autor:
Neal F. Osborne
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 1. :1429
A general method for the preparation of α-bromoallenic esters (2) involving the reaction of an acid chloride with a carboxybromomethylenetriphenylphosphorane has been developed. Reaction of these esters with the 4-mercaptoazetidin-2-one (1) gave ris
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05daec6c22c7603a10383763a3f48973
https://doi.org/10.1039/p19820001429
https://doi.org/10.1039/p19820001429
Autor:
A. John Eglington, Edward G. Brain, John H. C. Nayler, Robert Southgate, Neal F. Osborne, Patricia Tolliday
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 1. :2479
6-Acylaminopenam-3-carboxylic esters substituted at C-2 by one or two alkoxycarbonyl groups or by an acetyl group have been prepared from penicillins. The azetidinone ring remained intact throughout the reaction sequence, and the thiazolidine ring wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4ebc372ff8172e6f82193bcce0bd8f0
https://doi.org/10.1039/p19770002479
https://doi.org/10.1039/p19770002479
Autor:
Neal F. Osborne
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 1. :146
(3R,4R)-4-Mercapto-3-phenoxyacetamidoazetidin-2-one (4) has been prepared in good yield from the penicillin V-derived thiazoline-azetidinone (1). Alkylation and acylation led exclusively to S-substituted azetidinones. Reaction with dimethyl acetylene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::575c1629bda6ab003db236019f672c6c
https://doi.org/10.1039/p19800000146
https://doi.org/10.1039/p19800000146
Autor:
Neal F. Osborne
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 1. :1435
Reaction of the 4-mercaptoazetidin-2-one (6) with benzyl 2-bromocyclopropylideneacetate (7) gave the C-3 epimeric cyclopropanespiro-2-bisnorpenicillanates (9) and (10). Standard procedures were used to convert the 3S-epimer into the ampicillin analog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::087f5c672d17e03bc46b60103a5445cd
https://doi.org/10.1039/p19820001435
https://doi.org/10.1039/p19820001435
Autor:
Ian McMillan, Robert Southgate, John H. C. Nayler, Michael J. Pearson, Michael A. Harris, Neal F. Osborne
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 1. :1612
Treatment of benzyl 6β-(triphenylmethylamino)penicillanate with 3-substituted prop-2-ynyl bromides in the presence of strong base gave 1,2-secopenicillanates, which on permanganate oxidation afforded (3R,4R)-4-(3-substituted prop-2-ynylthio)-3-(trip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d8ce5744392b403b3c811943fdbf368
https://doi.org/10.1039/p19760001612
https://doi.org/10.1039/p19760001612
Autor:
Neal F. Osborne
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 1. :150
Reaction of the 4-mercaptoazetidinone (2) with benzyl 2-bromoacrylate gave the C-3-epimeric bisnorpenicillin esters (6b) and (7b). Standard procedures were used to convert the ester (6b) into bisnorpenicillin V (3) and bisnorampicillin (15). By contr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b802ccf103097a46f3231ef10c68da67
https://doi.org/10.1039/p19800000150
https://doi.org/10.1039/p19800000150
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 1. :1615
Addition of secondary amines to the triple bond of 4-(3-substituted prop-2-ynylthio)azetidin-2-ones or the derived sulphoxides, followed by very ready hydrolysis of the resulting enamines, provides a convenient route to the corresponding β-oxo-sulph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dfc5fce9c91046ab3f6a853d9cb561fa
https://doi.org/10.1039/p19760001615
https://doi.org/10.1039/p19760001615