Zobrazeno 1 - 10
of 2 583
pro vyhledávání: '"Neal F"'
Autor:
Sarah B Lieber, Mangala Rajan, Lisa A Mandl, Robyn A Lipschultz, Shahrez Syed, Sara Venkatraman, Myriam Lin, M Carrington Reid, Neal F Lue
Publikováno v:
Lupus Science and Medicine, Vol 11, Iss 1 (2024)
Objective Frailty and objective hand grip strength (one of the components of the frailty phenotype) are both risk factors for worse health outcomes in SLE. Whether telomere length, an established cellular senescence marker, is a biologic correlate of
Externí odkaz:
https://doaj.org/article/08c0915801be4e2184973ab70889f216
Autor:
Fei Li, Yizhe Wang, Inah Hwang, Ja-Young Jang, Libo Xu, Zhong Deng, Eun Young Yu, Yiming Cai, Caizhi Wu, Zhenbo Han, Yu-Han Huang, Xiangao Huang, Ling Zhang, Jun Yao, Neal F. Lue, Paul M. Lieberman, Haoqiang Ying, Jihye Paik, Hongwu Zheng
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Alternative lengthening of telomeres (ALT) provides cancer cells a mechanism to sustain replicative immortality. Here, the authors identify KDM2A as a molecular vulnerability in ALT-dependent cancer cells and demonstrate its role in the resolution of
Externí odkaz:
https://doaj.org/article/94cf5acf3ae146119f45347a657f708e
Publikováno v:
Journal of Hematology & Oncology, Vol 15, Iss 1, Pp 1-16 (2022)
Abstract A cardinal feature that distinguishes clinically high-risk neuroblastoma from low-risk tumors is telomere maintenance. Specifically, neuroblastoma tumors with either active telomerase or alternative lengthening of telomeres exhibit aggressiv
Externí odkaz:
https://doaj.org/article/2372cadc8e4f4bd1a272385fdb78b882
Autor:
Eun Young Yu, Syed S. Zahid, Sarah Aloe, Erik Falck-Pedersen, Xi Kathy Zhou, Nai-Kong V. Cheung, Neal F. Lue
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Yu et al. identify marked differences in the telomere and immunologic profiles of neuroblastoma cell lines displaying MES and ADRN lineage characteristics. They show that pharmacologically converting ADRN into MES cells triggers associated switch in
Externí odkaz:
https://doaj.org/article/1eeed91d3da54a22addff8ebe245c52a
Publikováno v:
PLoS Genetics, Vol 18, Iss 5, p e1010182 (2022)
The telomere G-strand binding protein Pot1 plays multifaceted roles in telomere maintenance and protection. We examined the structure and activities of Pot1 in Ustilago maydis, a fungal model that recapitulates key features of mammalian telomere regu
Externí odkaz:
https://doaj.org/article/3e48d99eb40d41e0884a6f259bb221e7
Autor:
Eun Young Yu, Syed S. Zahid, Swapna Ganduri, Jeanette H. Sutherland, Min Hsu, William K. Holloman, Neal F. Lue
Publikováno v:
Communications Biology, Vol 3, Iss 1, Pp 1-12 (2020)
Yu et al. provide evidence that Ustilago maydis employs two structurally distinct telomere-binding proteins to perform complementary functions in telomere maintenance in this organism. While UmTay1 regulates primarily telomere replication and recombi
Externí odkaz:
https://doaj.org/article/c58ce736a72344009df7a09b6fe8890a
Autor:
Kamel Mansouri, Neal F. Cariello, Alexandru Korotcov, Valery Tkachenko, Chris M. Grulke, Catherine S. Sprankle, David Allen, Warren M. Casey, Nicole C. Kleinstreuer, Antony J. Williams
Publikováno v:
Journal of Cheminformatics, Vol 11, Iss 1, Pp 1-20 (2019)
Abstract Background The logarithmic acid dissociation constant pKa reflects the ionization of a chemical, which affects lipophilicity, solubility, protein binding, and ability to pass through the plasma membrane. Thus, pKa affects chemical absorption
Externí odkaz:
https://doaj.org/article/4f55baf346f34fe88b0e95561bea6d46
Autor:
Eun Young Yu, Irene Y. Cheung, Yi Feng, Mohamed O. Rabie, Gail J. Roboz, Monica L. Guzman, Nai-Kong V. Cheung, Neal F. Lue
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 21, Iss 7, Pp 689-701 (2019)
Telomeres play important roles in genome stability and cell proliferation. High risk neuroblastoma (HRNB), an aggressive childhood cancer, is especially reliant on telomere maintenance. Three recurrent genetic aberrations in HRNB (MYCN amplification,
Externí odkaz:
https://doaj.org/article/d0c72d3b39b640f48d620effd9951725
Autor:
Neal F. Lue
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
The telomere protein assemblies in different fungal lineages manifest quite profound structural and functional divergence, implying a high degree of flexibility and adaptability. Previous comparative analyses of fungal telomeres have focused on the r
Externí odkaz:
https://doaj.org/article/d004de416aae4cc1bbbd30bf528fd2ef
Publikováno v:
Microbial Cell, Vol 5, Iss 9, Pp 393-403 (2018)
Telomeres play important roles in genome stability and cell proliferation. Telomere lengths are heterogeneous and because just a few abnormal telomeres are sufficient to trigger significant cellular response, it is informative to have accurate assays
Externí odkaz:
https://doaj.org/article/6f657e8c519d49b88df53b44d3be556d