Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Neal D. Heuss"'
Autor:
Scott W. McPherson, Neal D. Heuss, Md. Abedin, Heidi Roehrich, Mark J. Pierson, Dale S. Gregerson
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-17 (2022)
Abstract Background Characterizing immune cells and conditions that govern their recruitment and function in autoimmune diseases of the nervous system or in neurodegenerative processes is an area of active investigation. We sought to analyze the orig
Externí odkaz:
https://doaj.org/article/2a641efde8df410c8185e91b947ffbb4
Autor:
Scott W. McPherson, Neal D. Heuss, Ute Lehmann, Heidi Roehrich, Md. Abedin, Dale S. Gregerson
Publikováno v:
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-19 (2019)
Abstract Background Microglia are essential to the development of the CNS and its homeostasis. Our prior findings suggested a niche model to describe the behaviors of retinal microglia. Here, we ask whether new myeloid cells recruited to the retina a
Externí odkaz:
https://doaj.org/article/1bee8f55825a48459ffedaf09909018f
Autor:
Neal D. Heuss, Mark J. Pierson, Heidi Roehrich, Scott W. McPherson, Andrea L. Gram, Ling Li, Dale S. Gregerson
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-19 (2018)
Abstract Using mice expressing green fluorescent protein (GFP) from a transgenic CD11c promoter we found that a controlled optic nerve crush (ONC) injury attracted GFPhi retinal myeloid cells to the dying retinal ganglion cells and their axons. Howev
Externí odkaz:
https://doaj.org/article/604f904262024e8fb733d4220c4a0a13
Publikováno v:
Neurobiology of Disease, Vol 40, Iss 1, Pp 177-184 (2010)
The presence and activity of dendritic cells (DC) in retina is controversial, as these cells are difficult to identify in retina due to limited markers and sparse numbers. Transgenic mice that express green fluorescent protein (GFP) on the CD11c prom
Externí odkaz:
https://doaj.org/article/18e76b34990540b0afc85e685f2ad45b
Autor:
Marcela Maldonado, Rebecca J Kapphahn, Marcia R Terluk, Neal D Heuss, Ching Yuan, Dale S Gregerson, Deborah A Ferrington
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e56187 (2013)
Immunoproteasome is a protease abundant in immune cells and also present, albeit at lower concentrations, in cells outside the immune system. Recent evidence supports a novel role for the immunoproteasome in the cellular stress response potentially t
Externí odkaz:
https://doaj.org/article/cd1c5e0e859d494d9a13e93eba8c9d23
Publikováno v:
Frontiers in Immunology, Vol 3 (2012)
While pathogenic CD4 T cells are well known mediators of autoimmune uveoretinitis, CD8 T cells can also be uveitogenic. Since preliminary studies indicated that C57BL/6 mice were minimally susceptible to autoimmune uveoretinitis induction by CD8 T ce
Externí odkaz:
https://doaj.org/article/1ab2ebb0b0d346f2a542e1786ba460e2
Publikováno v:
Molecular and Cellular Neuroscience. 85:70-81
Background Studies of antigen presentation in retina using mice that expressed green fluorescent protein (GFP) from a transgenic CD11c promoter found that retinal GFP hi cells possessed antigen presentation function. Subsequent studies found that the
Autor:
Eric F Tewalt, Jean M Grant, Erica L Granger, Douglas C Palmer, Neal D Heuss, Dale S Gregerson, Nicholas P Restifo, Christopher C Norbury
Publikováno v:
PLoS Pathogens, Vol 5, Iss 5, p e1000457 (2009)
Virus-specific CD8(+) T cells (T(CD8+)) are initially triggered by peptide-MHC Class I complexes on the surface of professional antigen presenting cells (pAPC). Peptide-MHC complexes are produced by two spatially distinct pathways during virus infect
Externí odkaz:
https://doaj.org/article/0c88fc6736a94c98b98d402d66bd3a91
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose We previously demonstrated that passive transfer of lymphocytes from glaucomatous mice induces retinal ganglion cell (RGC) damage in recipient animals, suggesting a role for immune responses in the multifactorial pathophysiology of glaucoma.
Autor:
Ling Li, Scott W. McPherson, Andrea L. Gram, Neal D. Heuss, Mark Pierson, Dale S. Gregerson, Heidi Roehrich
Publikováno v:
Acta Neuropathologica Communications
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-19 (2018)
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-19 (2018)
Using mice expressing green fluorescent protein (GFP) from a transgenic CD11c promoter we found that a controlled optic nerve crush (ONC) injury attracted GFPhi retinal myeloid cells to the dying retinal ganglion cells and their axons. However, the o