Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Neal D. Amin"'
Publikováno v:
STAR Protocols, Vol 3, Iss 1, Pp 101130- (2022)
Summary: microRNAs (miRNAs) have unique gene regulatory effects in different neuronal subpopulations. Here, we describe a protocol to identify neuronal subtype-specific effects of a miRNA in murine motor neuron subpopulations. We detail the preparati
Externí odkaz:
https://doaj.org/article/39dcae4fa90e46eb89090c1f00ffda7f
Autor:
Jimena Andersen, Nicholas Thom, Jennifer L. Shadrach, Xiaoyu Chen, Massimo Mario Onesto, Neal D. Amin, Se-Jin Yoon, Li Li, William J. Greenleaf, Fabian Müller, Anca M. Pașca, Julia A. Kaltschmidt, Sergiu P. Pașca
Publikováno v:
Nature Neuroscience. 26:902-914
Autor:
Omer Revah, Felicity Gore, Kevin W. Kelley, Jimena Andersen, Noriaki Sakai, Xiaoyu Chen, Min-Yin Li, Fikri Birey, Xiao Yang, Nay L. Saw, Samuel W. Baker, Neal D. Amin, Shravanti Kulkarni, Rachana Mudipalli, Bianxiao Cui, Seiji Nishino, Gerald A. Grant, Juliet K. Knowles, Mehrdad Shamloo, John R. Huguenard, Karl Deisseroth, Sergiu P. Pașca
Publikováno v:
Nature. 610:319-326
Self-organizing neural organoids represent a promising in vitro platform with which to model human development and disease1–5. However, organoids lack the connectivity that exists in vivo, which limits maturation and makes integration with other ci
Autor:
Jimena Andersen, Nicholas Thom, Jennifer L. Shadrach, Xiaoyu Chen, Neal D. Amin, Se-Jin Yoon, William J. Greenleaf, Fabian Müller, Anca M. Pașca, Julia A. Kaltschmidt, Sergiu Pașca
Understanding spinal cord generation and assembly is essential to elucidate how motor behavior is controlled and how disorders arise. The cellular landscape of the human spinal cord remains, however, insufficiently explored. Here, we profiled the mid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8aa1ca69935ed663f974df43f61334d
https://doi.org/10.1101/2021.12.29.473693
https://doi.org/10.1101/2021.12.29.473693
Autor:
Luis F. Martins, Ilaria Brambilla, Alessia Motta, Stefano de Pretis, Ganesh Parameshwar Bhat, Aurora Badaloni, Chiara Malpighi, Neal D. Amin, Fumiyasu Imai, Ramiro D. Almeida, Yutaka Yoshida, Samuel L. Pfaff, Dario Bonanomi
Publikováno v:
Neuron
The nervous system requires metabolites and oxygen supplied by the neurovascular network, but this necessitates close apposition of neurons and endothelial cells. We find motor neurons attract vessels with long-range VEGF signaling, but endothelial c
Autor:
Jonathan A. Bernstein, Julia M. Schaepe, Themasap Khan, Yishan Sun, Anna K. Krawisz, Judith L. Rapoport, Neal D. Amin, Masayuki Yazawa, Yuan Tian, Min-Yin Li, Carrie E. Bearden, Matthew H. Porteus, Seiji Nishino, Ruth O'Hara, Aaron Gordon, Sergiu P. Paşca, John R. Huguenard, Ricardo E. Dolmetsch, Omer Revah, Leila Kushan, Noriaki Sakai, Daniel H. Geschwind, Se-Jin Yoon, Chul Hoon Kim, Joachim Hallmayer, Carleton Goold, Kazuya Ikeda
Publikováno v:
Nature medicine, vol 26, iss 12
Nat Med
Nat Med
22q11.2 deletion syndrome (22q11DS) is a highly penetrant and common genetic cause of neuropsychiatric disease. Here we generated induced pluripotent stem cells from 15 individuals with 22q11DS and 15 control individuals and differentiated them into
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afdbc3b1fcaaf3737a78f5f040438e5b
https://escholarship.org/uc/item/9dn604d3
https://escholarship.org/uc/item/9dn604d3
Autor:
Peter J. Osseward, Bianca K. Barriga, Marito Hayashi, Lukas C. Bachmann, Jeffrey D. Moore, Robert C. Clark, Miriam Gullo, Samuel L. Pfaff, Fernando Beltran, Shawn P. Driscoll, Neal D. Amin, Benjamin A. Temple
Publikováno v:
Science
Motor and sensory functions of the spinal cord are mediated by populations of cardinal neurons arising from separate progenitor lineages. However, each cardinal class is composed of multiple neuronal types with distinct molecular, anatomical, and phy
Autor:
Brendan O'Leary, Shawn P. Driscoll, Giancarlo Costaguta, Dario Bonanomi, Neal D. Amin, Samuel L. Pfaff, Gokhan Senturk
Publikováno v:
Neuron. 109:3252-3267.e6
Summary Disruption of homeostatic microRNA (miRNA) expression levels is known to cause human neuropathology. However, the gene regulatory and phenotypic effects of altering a miRNA’s in vivo abundance (rather than its binary gain or loss) are not w
Autor:
Elisabeth M. Walczak, Jimena Andersen, Hannes Vogel, Sergiu P. Paşca, Xiaoyu Chen, H. Christina Fan, Omer Revah, Kevin W. Kelley, Neal D. Amin, Mandeep Singh, Nicholas Thom, Mayuri Vijay Thete, Yuki Miura
Publikováno v:
Cell. 183:1913-1929.e26
Summary Neurons in the cerebral cortex connect through descending pathways to hindbrain and spinal cord to activate muscle and generate movement. Although components of this pathway have been previously generated and studied in vitro, the assembly of
Autor:
Neal D. Amin, Sergiu P. Paşca
Publikováno v:
Neuron. 100(2)
Disorders of the nervous system are challenging to study and treat due to the relative inaccessibility of functional human brain tissue for research. Stem cell-derived 3D human brain organoids have the potential to recapitulate features of the human