Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Neal A. Brown"'
Publikováno v:
Bioorganicmedicinal chemistry. 27(15)
Despite the growing global crisis caused by antimicrobial drug resistance among pathogenic bacteria, the number of new antibiotics, especially new chemical class of antibiotics under development is insufficient to tackle the problem. Our review focus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e8bf3182e9ba2e69ae0518f370abb59
https://pubmed.ncbi.nlm.nih.gov/31221610
https://pubmed.ncbi.nlm.nih.gov/31221610
Autor:
Neal, Terri Brown, Piccorossi, Vanessa York, Kattoor, James, Genest, Karen, Taylor, Kate, O'Shea, Monica, McHugh, Rosemary, Rush, Adrian, Grosek, Gerald, Marranazo, Avi, Valverde, Spencer, Toro, Noel, Ng, Violet, Roach, Clare Deckelman
Publikováno v:
U.S. Catholic. Apr2017, Vol. 82 Issue 4, p5-7. 3p. 1 Color Photograph.
Publikováno v:
Infectious Disorders - Drug Targets. 12:327-331
DNA polymerases pol IIIC and dnaE [i.e. pol IIIE] are essential for replicative DNA synthesis in low G:C Gram-positive eubacteria. Therefore, they have strong potential as targets for development of Gram-positive-selective antibacterial agents. This
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94648c2e44aa591f984a5e9d3272b1f1
https://doi.org/10.2174/187152612804142279
https://doi.org/10.2174/187152612804142279
Autor:
Wei-Chu Xu, Andrea Torti, Neal C. Brown, Andrea Lossani, George E. Wright, Lida Savi, Federico Focher
Publikováno v:
Current Enzyme Inhibition. 7:147-153
Based on the finding that aerobic Gram-positive antibacterials that inhibit DNA polymerase IIIC (pol IIIC) were potent inhibitors of the growth of anaerobic Clostridium difficile (CD) strains, we chose to clone and express the gene for pol IIIC from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1259ea97ed9bd2d55c53e3ff7b7e005
https://doi.org/10.2174/157340811798807597
https://doi.org/10.2174/157340811798807597
Autor:
Michelle M. Butler, Joseph Gambino, Neal C. Brown, Sofya Dvoskin, Zheng-yu Long, George E. Wright, Marjorie H. Barnes, Wei-Chu Xu, Chengxin Zhi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:4197-4202
Several 2-anilino- and 2-benzylamino-3-deaza-6-oxopurines [3-deazaguanines] and selected 8-methyl and 8-aza analogs have been synthesized. 7-Substituted N2-(3-ethyl-4-methylphenyl)-3-deazaguanines were potent and selective inhibitors of Gram+ bacteri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ec0380398f2183adc920068378ba90f
https://doi.org/10.1016/j.bmcl.2011.05.093
https://doi.org/10.1016/j.bmcl.2011.05.093
Autor:
Zheng-yu Long, George E. Wright, Richard Storer, Karsten A. Holm, Neal C. Brown, Andrzej Manikowski, Donna J. Skow, Kimberly A. Foster, Serge Lamothe, Paul M. Tarantino, Irina Motorina, Michelle M. Butler, Chengxin Zhi, William A. LaMarr, Edward J. Dix
Publikováno v:
Journal of Medicinal Chemistry. 48:7063-7074
Numerous 3-substituted-6-(3-ethyl-4-methylanilino)uracils (EMAU) have been synthesized and screened for their capacity to inhibit the replication-specific bacterial DNA polymerase IIIC (pol IIIC) and the growth of Gram+ bacteria in culture. Direct al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8975de033417761467d60c8c160fadd5
https://doi.org/10.1021/jm050517r
https://doi.org/10.1021/jm050517r
Autor:
George E. Wright, Zheng-yu Long, Marjorie H. Barnes, Michelle M. Butler, Chengxin Zhi, Joseph Gambino, Wei-Chu Xu, Neal C. Brown
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:729-732
7-Substituted-N(2)-(3,4-dichlorobenzyl)guanines potently and competitively inhibit DNA polymerases IIIC and IIIE from Gram(+) bacteria. Certain derivatives are also competitive inhibitors of DNA polymerase IIIE from Gram(-) bacteria.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4783294df115458ba9346baba8f84f95
https://doi.org/10.1016/j.bmcl.2004.11.016
https://doi.org/10.1016/j.bmcl.2004.11.016
Autor:
George E. Wright, Marjorie H. Barnes, Joseph Gambino, Michelle M. Butler, Chengxin Zhi, Zheng-yu Long, William A. LaMarr, Neal C. Brown, Wei-Chu Xu
Publikováno v:
Journal of Medicinal Chemistry. 46:2731-2739
Certain substituted 6-anilinouracils are potent and selective inhibitors of Gram+ bacterial DNA polymerase IIIC (pol IIIC). In addition, analogues with 3-substituents in the uracil ring have potent antibacterial activity against Gram+ organisms in cu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1274231a3578db3418b3dd91d1b857e1
https://doi.org/10.1021/jm020591z
https://doi.org/10.1021/jm020591z
Autor:
Ryan O. Stephenson, Kimberly A. Foster, Marjorie H. Barnes, Donna J. Skow, Neal C. Brown, Michelle M. Butler, William A. LaMarr
Publikováno v:
Protein Expression and Purification. 27:90-97
Enterococcus faecalis (Ef) dnaE and polC, the respective genes encoding the DNA replication-specific DNA polymerase III E and DNA polymerase III C, were cloned and engineered for expression in Escherichia coli as hexahistidine (his6)-tagged recombina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f66850773e2f07e55fc197916af242b
https://doi.org/10.1016/s1046-5928(02)00577-6
https://doi.org/10.1016/s1046-5928(02)00577-6
Publikováno v:
Journal of Bacteriology. 184:3834-3838
dna E, the gene encoding one of the two replication-specific DNA polymerases (Pols) of low-GC-content gram-positive bacteria (E. Dervyn et al., Science 294:1716-1719, 2001; R. Inoue et al., Mol. Genet. Genomics 266:564-571, 2001), was cloned from Bac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00a4fcbf6f3b24269e4033f1684dddf7
https://doi.org/10.1128/jb.184.14.3834-3838.2002
https://doi.org/10.1128/jb.184.14.3834-3838.2002