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Synthesis of chromeno[3,4-b]indoles as Lamellarin D analogues : A novel DYRK1A inhibitor class

Autor: Neagoie, Cleopatra, Vedrenne, Emeline, Buron, Frédéric, Mérour, Jean-Yves, Rosca, Sorin, Bourg, Stéphane, Lozach, Olivier, Meijer, Laurent, Baldeyrou, Brigitte, Lansiaux, Amelie, Routier, Sylvain

Publikováno v: In European Journal of Medicinal Chemistry March 2012 49:379-396

Azetidines Kill Multidrug-Resistant Mycobacterium tuberculosiswithout Detectable Resistance by Blocking Mycolate Assembly

Autor: Cui, Yixin, Lanne, Alice, Peng, Xudan, Browne, Edward, Bhatt, Apoorva, Coltman, Nicholas J., Craven, Philip, Cox, Liam R., Cundy, Nicholas J., Dale, Katie, Feula, Antonio, Frampton, Jon, Fung, Martin, Morton, Michael, Goff, Aaron, Salih, Mariwan, Lang, Xingfen, Li, Xingjian, Moon, Chris, Pascoe, Jordan, Portman, Vanessa, Press, Cara, Schulz-Utermoehl, Timothy, Lee, Suki, Tortorella, Micky D., Tu, Zhengchao, Underwood, Zoe E., Wang, Changwei, Yoshizawa, Akina, Zhang, Tianyu, Waddell, Simon J., Bacon, Joanna, Alderwick, Luke, Fossey, John S., Neagoie, Cleopatra

Publikováno v: Journal of Medicinal Chemistry; 20240101, Issue: Preprints

Azetidines Kill Multidrug-Resistant Mycobacterium tuberculosis without Detectable Resistance by Blocking Mycolate Assembly.

Autor: Cui Y; School of Chemistry, University of Birmingham, Edgbaston, Birmingham, West Midlands B15 2TT, U.K., Lanne A; Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, Birmingham, West Midlands B15 2TT, U.K., Peng X; State Key Laboratory of Respiratory Disease, China-New Zealand Joint Laboratory on Biomedicine and Health, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Science, 190 Kai Yuan Avenue, Science Park, Guangzhou 510530, China., Browne E; Sygnature Discovery, The Discovery Building, BioCity, Pennyfoot Street, Nottingham NG1 1GR, U.K., Bhatt A; Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, Birmingham, West Midlands B15 2TT, U.K., Coltman NJ; School of Biosciences, University of Birmingham, Edgbaston, Birmingham, West Midlands B15 2TT, U.K., Craven P; School of Chemistry, University of Birmingham, Edgbaston, Birmingham, West Midlands B15 2TT, U.K., Cox LR; School of Chemistry, University of Birmingham, Edgbaston, Birmingham, West Midlands B15 2TT, U.K., Cundy NJ; School of Chemistry, University of Birmingham, Edgbaston, Birmingham, West Midlands B15 2TT, U.K., Dale K; Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, Birmingham, West Midlands B15 2TT, U.K., Feula A; School of Chemistry, University of Birmingham, Edgbaston, Birmingham, West Midlands B15 2TT, U.K., Frampton J; College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, West Midlands B15 2TT, U.K., Fung M; Centre for Regenerative Medicine and Health, Hong Kong Institute of Science & Innovation, Chinese Academy of Sciences, 15 Science Park West Avenue NT, Hong Kong SAR., Morton M; ApconiX Ltd, BIOHUB at Alderly Park, Nether Alderly, Cheshire SK10 4TG, U.K., Goff A; Department of Global Health and Infection, Brighton and Sussex Medical School, University of Sussex, Falmer BN1 9PX, U.K., Salih M; School of Chemistry, University of Birmingham, Edgbaston, Birmingham, West Midlands B15 2TT, U.K., Lang X; State Key Laboratory of Respiratory Disease, China-New Zealand Joint Laboratory on Biomedicine and Health, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Science, 190 Kai Yuan Avenue, Science Park, Guangzhou 510530, China., Li X; School of Chemistry, University of Birmingham, Edgbaston, Birmingham, West Midlands B15 2TT, U.K.; State Key Laboratory of Respiratory Disease, China-New Zealand Joint Laboratory on Biomedicine and Health, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Science, 190 Kai Yuan Avenue, Science Park, Guangzhou 510530, China., Moon C; TB Research Group, National Infection Service, Public Health England (UKHSA), Manor Farm Road, Porton, Salisbury SP4 0JG, U.K., Pascoe J; TB Research Group, National Infection Service, Public Health England (UKHSA), Manor Farm Road, Porton, Salisbury SP4 0JG, U.K., Portman V; Sygnature Discovery, The Discovery Building, BioCity, Pennyfoot Street, Nottingham NG1 1GR, U.K., Press C; Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, Birmingham, West Midlands B15 2TT, U.K., Schulz-Utermoehl T; Sygnature Discovery, The Discovery Building, BioCity, Pennyfoot Street, Nottingham NG1 1GR, U.K., Lee S; Centre for Regenerative Medicine and Health, Hong Kong Institute of Science & Innovation, Chinese Academy of Sciences, 15 Science Park West Avenue NT, Hong Kong SAR., Tortorella MD; State Key Laboratory of Respiratory Disease, China-New Zealand Joint Laboratory on Biomedicine and Health, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Science, 190 Kai Yuan Avenue, Science Park, Guangzhou 510530, China.; Centre for Regenerative Medicine and Health, Hong Kong Institute of Science & Innovation, Chinese Academy of Sciences, 15 Science Park West Avenue NT, Hong Kong SAR., Tu Z; State Key Laboratory of Respiratory Disease, China-New Zealand Joint Laboratory on Biomedicine and Health, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Science, 190 Kai Yuan Avenue, Science Park, Guangzhou 510530, China., Underwood ZE; TB Research Group, National Infection Service, Public Health England (UKHSA), Manor Farm Road, Porton, Salisbury SP4 0JG, U.K., Wang C; State Key Laboratory of Respiratory Disease, China-New Zealand Joint Laboratory on Biomedicine and Health, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Science, 190 Kai Yuan Avenue, Science Park, Guangzhou 510530, China., Yoshizawa A; School of Chemistry, University of Birmingham, Edgbaston, Birmingham, West Midlands B15 2TT, U.K., Zhang T; State Key Laboratory of Respiratory Disease, China-New Zealand Joint Laboratory on Biomedicine and Health, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Science, 190 Kai Yuan Avenue, Science Park, Guangzhou 510530, China., Waddell SJ; Department of Global Health and Infection, Brighton and Sussex Medical School, University of Sussex, Falmer BN1 9PX, U.K., Bacon J; TB Research Group, National Infection Service, Public Health England (UKHSA), Manor Farm Road, Porton, Salisbury SP4 0JG, U.K., Alderwick L; Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, Birmingham, West Midlands B15 2TT, U.K.; Discovery Sciences, Charles River Laboratories, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Fossey JS; School of Chemistry, University of Birmingham, Edgbaston, Birmingham, West Midlands B15 2TT, U.K., Neagoie C; State Key Laboratory of Respiratory Disease, China-New Zealand Joint Laboratory on Biomedicine and Health, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Science, 190 Kai Yuan Avenue, Science Park, Guangzhou 510530, China.; Centre for Regenerative Medicine and Health, Hong Kong Institute of Science & Innovation, Chinese Academy of Sciences, 15 Science Park West Avenue NT, Hong Kong SAR.; Visiting Scientist, School of Chemistry, University of Birmingham, Edgbaston, Birmingham, West Midlands B15 2TT, U.K.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2024 Feb 22; Vol. 67 (4), pp. 2529-2548. Date of Electronic Publication: 2024 Feb 08.