Plasmodium falciparum-specific memory B-cell and antibody responses are associated with immunity in children living in an endemic area of Kenya

Autor: Jahnmatz, P, Nyabundi, D, Sundling, C, Widman, L, Mwacharo, J, Musyoki, J, Otieno, E, Ahlborg, N, Bejon, P, Ndungu, FM, Färnert, A

Identifying the mechanism of naturally acquired immunity against Plasmodium falciparum malaria could contribute to the design of effective malaria vaccines. Using a recently developed multiplexed FluoroSpot assay, we assessed cross-sectional pre-exis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1064::88c92cebd435dab51801244cf100d7be
https://doi.org/10.3389/fimmu.2022.799306

TRUE-1: Trial of Repurposed Unithiol for snakebite Envenoming phase 1 (safety, tolerability, pharmacokinetics and pharmacodynamics in healthy Kenyan adults)

Autor: Abouyannis, M, FitzGerald, R, Ngama, M, Mwangudzah, H, Nyambura, YK, Ngome, S, Riako, D, Babu, L, Lewa, F, Else, L, Dily Penchala, S, Orindi, B, Mumba, N, Kalama, B, Ndungu, FM, Adetifa, I, Khoo, S, Lalloo, DG, Casewell, NR, Hamaluba, M

Publikováno v: Wellcome Open Research. 7:90

Background: Snakebites affect over 5 million people each year, and over 100,000 per year die as a result. The only available treatment is antivenom, which has many shortcomings including high cost, intravenous administration, and high risk of adverse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::471fe842370c943a7997d652cdf40fe7
https://doi.org/10.12688/wellcomeopenres.17682.1

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Evaluation of copromicroscopy, multiplex-qPCR and antibody serology for monitoring of human ascariasis in endemic settings.

Autor: Mugo RM; Institute of Immunology, Centre for Infection Medicine, Freie Universität Berlin, Berlin, Germany., Rausch S; Institute of Immunology, Centre for Infection Medicine, Freie Universität Berlin, Berlin, Germany., Musimbi ZD; Institute of Immunology, Centre for Infection Medicine, Freie Universität Berlin, Berlin, Germany., Strube C; Institute for Parasitology, Centre for Infection Medicine, University of Veterinary Medicine Hannover, Hannover, Germany., Raulf MK; Institute for Parasitology, Centre for Infection Medicine, University of Veterinary Medicine Hannover, Hannover, Germany., Landt O; TIB Molbiol Syntheselabor GmbH, Berlin, Germany., Gichuki PM; Eastern and Southern Africa Centre of International Parasite Control, Kenya Medical Research, Nairobi, Kenya., Ebner F; Institute of Immunology, Centre for Infection Medicine, Freie Universität Berlin, Berlin, Germany.; Department of Molecular Life Sciences, School of Life Sciences, Technical University of Munich, Munich, Germany., Mwacharo J; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya., Odiere MR; Centre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya., Ndungu FM; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Njomo DW; Eastern and Southern Africa Centre of International Parasite Control, Kenya Medical Research, Nairobi, Kenya., Hartmann S; Institute of Immunology, Centre for Infection Medicine, Freie Universität Berlin, Berlin, Germany.

Publikováno v: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2024 Jun 18; Vol. 18 (6), pp. e0012279. Date of Electronic Publication: 2024 Jun 18 (Print Publication: 2024).