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Amodiaquine resistance in Plasmodium berghei is associated with PbCRT His95Pro mutation, loss of chloroquine, artemisinin and primaquine sensitivity, and high transcript levels of key transporters.

Autor: Ndung'u L; PAUSTI, Jomo Kenyatta University of Agriculture and Technology, Nairobi, 00200, Kenya.; KEMRI- Centre for Traditional Medicine and Drug Research, Kenya Medical Research Institute (KEMRI), Nairobi, 00200, Kenya., Langat B; Department of Nursing and Nutritional Sciences, University of Kabianga, Kericho, 20200, Kenya., Magiri E; Department of Biochemistry, Jomo Kenyatta University of Agriculture and Technology, Nairobi, 00200, Kenya., Ng'ang'a J; Department of Biochemistry, Jomo Kenyatta University of Agriculture and Technology, Nairobi, 00200, Kenya., Irungu B; KEMRI- Centre for Traditional Medicine and Drug Research, Kenya Medical Research Institute (KEMRI), Nairobi, 00200, Kenya., Nzila A; Department of Life Sciences, King Fahd University of Petroleum and Minerals, Dharan, 31261, Saudi Arabia., Kiboi D; Department of Biochemistry, Jomo Kenyatta University of Agriculture and Technology, Nairobi, 00200, Kenya.; West Africa Centre for Cell Biology and Infectious Pathogens, University of Ghana, Accra, 54 Legon, Ghana.; Kenya Medical Research Institute (KEMRI)/Wellcome Trust, Collaborative Research Program, Kilifi, 80108, Kenya.

Publikováno v: Wellcome open research [Wellcome Open Res] 2017 Jun 20; Vol. 2, pp. 44. Date of Electronic Publication: 2017 Jun 20 (Print Publication: 2017).