Synergy of a STING agonist and an IL-2 superkine in cancer immunotherapy against MHC I-deficient and MHC I ⁺ tumors.

Autor: Wolf NK; Division of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720., Blaj C; Division of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720., Picton LK; HHMI, Stanford University School of Medicine, Stanford, CA 94305.; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305.; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305., Snyder G; Division of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720., Zhang L; Division of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720., Nicolai CJ; Division of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720., Ndubaku CO; Aduro Biotech, Inc., Berkeley, CA 94710., McWhirter SM; Aduro Biotech, Inc., Berkeley, CA 94710., Garcia KC; HHMI, Stanford University School of Medicine, Stanford, CA 94305.; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305.; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305., Raulet DH; Division of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2022 May 31; Vol. 119 (22), pp. e2200568119. Date of Electronic Publication: 2022 May 19.

Targeting PI3K family with small-molecule inhibitors in cancer therapy: current clinical status and future directions.

Autor: Li, Hongyao^1,2,3 (AUTHOR), Wen, Xiang³ (AUTHOR), Ren, Yueting^3,4 (AUTHOR), Fan, Zhichao^1,2,3 (AUTHOR), Zhang, Jin⁵ (AUTHOR) zhangjin1989@szu.edu.cn, He, Gu³ (AUTHOR) hegu@scu.edu.cn, Fu, Leilei^1,2 (AUTHOR) leilei_fu@163.com

Publikováno v: Molecular Cancer. 8/10/2024, Vol. 23 Issue 1, p1-42. 42p.

Magnitude of Therapeutic STING Activation Determines CD8 ⁺ T Cell-Mediated Anti-tumor Immunity.

Autor: Sivick KE, Desbien AL, Glickman LH, Reiner GL, Corrales L, Surh NH, Hudson TE, Vu UT, Francica BJ, Banda T, Katibah GE, Kanne DB, Leong JJ, Metchette K, Bruml JR, Ndubaku CO, McKenna JM, Feng Y, Zheng L, Bender SL, Cho CY, Leong ML, van Elsas A, Dubensky TW Jr, McWhirter SM

Publikováno v: Cell reports [Cell Rep] 2019 Oct 15; Vol. 29 (3), pp. 785-789.

Combining STING-based neoantigen-targeted vaccine with checkpoint modulators enhances antitumor immunity in murine pancreatic cancer.

Autor: Kinkead HL; Sidney Kimmel Comprehensive Cancer Center, Skip Viragh Center for Pancreatic Cancer, The Bloomberg~Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Hopkins A; Sidney Kimmel Comprehensive Cancer Center, Skip Viragh Center for Pancreatic Cancer, The Bloomberg~Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Lutz E; Sidney Kimmel Comprehensive Cancer Center, Skip Viragh Center for Pancreatic Cancer, The Bloomberg~Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Wu AA; Sidney Kimmel Comprehensive Cancer Center, Skip Viragh Center for Pancreatic Cancer, The Bloomberg~Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Yarchoan M; Sidney Kimmel Comprehensive Cancer Center, Skip Viragh Center for Pancreatic Cancer, The Bloomberg~Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Cruz K; Sidney Kimmel Comprehensive Cancer Center, Skip Viragh Center for Pancreatic Cancer, The Bloomberg~Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Woolman S; Sidney Kimmel Comprehensive Cancer Center, Skip Viragh Center for Pancreatic Cancer, The Bloomberg~Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Vithayathil T; Sidney Kimmel Comprehensive Cancer Center, Skip Viragh Center for Pancreatic Cancer, The Bloomberg~Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Glickman LH; Aduro Biotechnologies Inc., Berkeley, California, USA.; Actym Therapeutics Inc., Berkeley, California, USA., Ndubaku CO; Aduro Biotechnologies Inc., Berkeley, California, USA., McWhirter SM; Aduro Biotechnologies Inc., Berkeley, California, USA., Dubensky TW Jr; Aduro Biotechnologies Inc., Berkeley, California, USA.; Tempest Therapeutics, San Francisco, California, USA., Armstrong TD; Sidney Kimmel Comprehensive Cancer Center, Skip Viragh Center for Pancreatic Cancer, The Bloomberg~Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Jaffee EM; Sidney Kimmel Comprehensive Cancer Center, Skip Viragh Center for Pancreatic Cancer, The Bloomberg~Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Zaidi N; Sidney Kimmel Comprehensive Cancer Center, Skip Viragh Center for Pancreatic Cancer, The Bloomberg~Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Publikováno v: JCI insight [JCI Insight] 2018 Oct 18; Vol. 3 (20). Date of Electronic Publication: 2018 Oct 18.

Role of STING in the treatment of non-small cell lung cancer.

Autor: Tang, Wenhua¹ (AUTHOR), Zhou, Wenjie¹ (AUTHOR), Ji, Mei¹ (AUTHOR), Yang, Xin¹ (AUTHOR) yangxindoctor@163.com

Publikováno v: Cell Communication & Signaling. 4/2/2024, Vol. 22 Issue 1, p1-15. 15p.