Estradiol-17β upregulates pyruvate kinase M2 expression to coactivate estrogen receptor-α and to integrate metabolic reprogramming with the mitogenic response in endometrial cells.

Autor: Salama SA; Department of Obstetrics and Gynecology (S.A.S., C.R.D.-A., B.T.N.), Division of Gynecologic Oncology; Department of Pediatrics (M.A.M.), Children's Nutrition Research Center, U.S. Department of Agriculture/Agricultural Research Service; and Department of Pediatric Hematology-Oncology (M.S.A.-B.), Texas Children's Hospital, Baylor College of Medicine, Houston, Texas 77030; Department of Tumor Biology (M.W.K.), Unit of Pharmacology, National Cancer Institute, Cairo University, Egypt; and Department of Obstetrics and Gynecology (G.S.K.), University of Texas Medical Branch, Galveston, Texas 77555; and Section of Biostatistics and Epidemiology (S.K.T.), Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire 03755., Mohammad MA, Diaz-Arrastia CR, Kamel MW, Kilic GS, Ndofor BT, Abdel-Baki MS, Theiler SK

Publikováno v: The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2014 Oct; Vol. 99 (10), pp. 3790-9. Date of Electronic Publication: 2014 Jan 28.